Evidence map›Paper›PMID 24763584›Full record

ArticleScience (New York, N.Y.)2014

Genome sequence of the tsetse fly (Glossina morsitans): vector of African trypanosomiasis.

International Glossina Genome Initiative

Open access · greenAbstract read
In one paragraph

Article in Science (New York, N.Y.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 145 papers.

0numbers the graph read from it
0cells of the map it votes in
145citing papers in PubMed
40.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

145 citing papers in PubMed, 258 citations in OpenAlex.

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  9. mir-31 mediated control of bacteriome size in tsetse flies.Current research in insect science · 2025
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85 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 20 institutions in 17 countries.

International Glossina Genome Initiative
Liverpool School of Tropical Medicine · GBUniversity of the Western Cape · ZAYale University · USThe Ohio State University · USUniversity of Cape Town · ZAUniversity of Pavia · ITEgerton University · KEInstitut de Recherche pour le Développement · BJInternational Centre of Insect Physiology and Ecology · KEJomo Kenyatta University of Agriculture and Technology · KETexas A&M University · USThe University of Tokyo · JPUniversity of Arizona · USUniversity of Liverpool · GBAberystwyth University · GBInstituut voor Tropische Geneeskunde · BEKU Leuven · BENational Institute of Advanced Industrial Science and Technology · JPNew Mexico State University · USUniversity of York · GB

Funding

Large Scale Genome SequencingU54HG003079 · NHGRI · WASHINGTON UNIVERSITY · PI DUTCHER, SUSAN K · 2004 to 2016
$445.7M
Molecular Aspects of Tsetse and Trypanosome TransmissionR01AI051584 · NIAID · YALE UNIVERSITY · PI AKSOY, SERAP · 2003 to 2013
$4.3M
Tsetse Fecundity Reduction for Trypanosomiasis ControlR01AI081774 · NIAID · YALE UNIVERSITY · PI AKSOY, SERAP · 2009 to 2013
$2.0M
Tsetse Transmitted African TrypanosomiasisD43TW007391 · FIC · YALE UNIVERSITY · PI AKSOY, SERAP · 2008 to 2017
$1.8M
Evidence based control strategies of Sleeping Sickness vectorsR03TW008413 · FIC · YALE UNIVERSITY · PI AKSOY, SERAP · 2010 to 2012
$175k
Molecular and functional characterization of olfaction genes in tsetse fliesR03TW009444 · FIC · YALE UNIVERSITY · PI AKSOY, SERAP · 2013 to 2015
$157k
NOVEL ANGIOGENIC/HEMATOPOIETIC SIGNALING PATHWAYSF32CA091768 · NCI · SCRIPPS RESEARCH INSTITUTE · PI PARISER, HAROLD P · 2001 to 2004
$97k
FIC NIH HHS D43 TW007391FIC NIH HHS R03 TW008413FIC NIH HHS R03 TW009444Medical Research Council MR/K002279/1NCI NIH HHS F32 CA091768NHGRI NIH HHS U54 HG003079NIAID NIH HHS R01 AI051584NIAID NIH HHS R01 AI081774Wellcome TrustWellcome Trust 085775/Z/08/ZWellcome Trust 098051
6 · The paper itself

Abstract

Tsetse flies are the sole vectors of human African trypanosomiasis throughout sub-Saharan Africa. Both sexes of adult tsetse feed exclusively on blood and contribute to disease transmission. Notable differences between tsetse and other disease vectors include obligate microbial symbioses, viviparous reproduction, and lactation. Here, we describe the sequence and annotation of the 366-megabase Glossina morsitans morsitans genome. Analysis of the genome and the 12,308 predicted protein-encoding genes led to multiple discoveries, including chromosomal integrations of bacterial (Wolbachia) genome sequences, a family of lactation-specific proteins, reduced complement of host pathogen recognition proteins, and reduced olfaction/chemosensory associated genes. These genome data provide a foundation for research into trypanosomiasis prevention and yield important insights with broad implications for multiple aspects of tsetse biology.

Indexed as

Genome, InsectAnimalsBloodFeeding BehaviorFemaleGenes, InsectInsect ProteinsInsect VectorsMicrobiotaMolecular Sequence AnnotationMolecular Sequence DataReproductionSalivary GlandsSensationSequence Analysis, DNASymbiosisInsect Proteins

Identifiers

PMID24763584
PMCPMC4077534
OpenAlexW2133552700

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.