ArticlePloS one2014
Multimodal brain connectivity analysis in unmedicated late-life depression.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Reduced nucleus accumbens functional connectivity in reward network and default mode network in patients with recurrent major depressive disorder.Translational psychiatry · 2022Pooled it
- Evidence for Structural and Functional Alterations of Frontal-Executive and Corticolimbic Circuits in Late-Life Depression and Relationship to Mild Cognitive Impairment and Dementia: A Systematic Review.Frontiers in neuroscience · 2020Pooled it
- Association of White Matter Integrity With Executive Function and Antidepressant Treatment Outcome in Patients With Late-Life Depression.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2021Trial
- Understanding Depression in Women Across the Lifespan: Hormonal Insights From Brain Imaging.Brain and behavior · 2026Review
- Cortico-limbic volume abnormalities in late life depression are distinct from β amyloid and white matter pathologies.Molecular psychiatry · 2025Article
- Depression and emotion regulation strategy use moderate age-related attentional positivity bias.Frontiers in psychology · 2024Article
- The need to change: Is there a critical role of midlife adaptation in mental health later in life?eLife · 2023Review
- Development of a Bayesian multimodal model to detect biomarkers in neuroimaging studies.Frontiers in neuroimaging · 2023Article
- Apathy: Neurobiology, Assessment and Treatment.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2021Article
- Sexual Dimorphism in the Brain Correlates of Adult-Onset Depression: A Pilot Structural and Functional 3T MRI Study.Frontiers in psychiatry · 2021Article
- Frontal-executive and corticolimbic structural brain circuitry in older people with remitted depression, mild cognitive impairment, Alzheimer's dementia, and normal cognition.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Vascular depression for radiology: A review of the construct, methodology, and diagnosis.World journal of radiology · 2020Review
- Functional connectivity predictors of acute depression treatment outcome.International psychogeriatrics · 2019Article
- The superior longitudinal fasciculus and its functional triple-network mechanisms in brooding.NeuroImage. Clinical · 2019Article
- Differential patterns of age-related cortical and subcortical functional connectivity in 6-to-10 year old children: A connectome-wide association study.Brain and behavior · 2018Article
- Advances and Barriers for Clinical Neuroimaging in Late-Life Mood and Anxiety Disorders.Current psychiatry reports · 2018Review
- Mutual Information-Based Brain Network Analysis in Post-stroke Patients With Different Levels of Depression.Frontiers in human neuroscience · 2018Article
- Association between change in brain gray matter volume, cognition, and depression severity: Pre- and post- antidepressant pharmacotherapy for late-life depression.Journal of psychiatric research · 2017Article
- Brain structural connectivity in late-life major depressive disorder.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2016Article
- Biophysical changes in subcortical nuclei: the impact of diabetes and major depression.Molecular psychiatry · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Late-life depression (LLD) is a common disorder associated with emotional distress, cognitive impairment and somatic complains. Structural abnormalities have been suggested as one of the main neurobiological correlates in LLD. However the relationship between these structural abnormalities and altered functional brain networks in LLD remains poorly understood. 15 healthy elderly comparison subjects from the community and 10 unmedicated and symptomatic subjects with geriatric depression were selected for this study. For each subject, 87 regions of interest (ROI) were generated from whole brain anatomical parcellation of resting state fMRI data. Whole-brain ROI-wise correlations were calculated and compared between groups. Group differences were assessed using an analysis of covariance after controlling for age, sex and education with multiple comparison correction using the false discovery rate. Structural connectivity was assessed by tract-based spatial statistics (TBSS). LLD subjects had significantly decreased connectivity between the right accumbens area (rA) and the right medial orbitofrontal cortex (rmOFC) as well as between the right rostral anterior cingulate cortex (rrACC) and bilateral superior frontal gyrus (bsSFG). Altered connectivity of rrACC with the bsSFG was significantly correlated with depression severity in depressed subjects. TBSS analysis showed a 20% reduction in fractional anisotropy (FA) in the right Forceps Minor (rFM) in depressed subjects. rFM FA values were positively correlated with rA-rmOFC and rrACC-bsFG functional connectivity values in our total study sample. Coordinated structural and functional impairment in circuits involved in emotion regulation and reward pathways play an important role in the pathophysiology of LLD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.