ArticleJournal of refractive surgery (Thorofare, N.J. : 1995)2014
Optical coherence tomography combined with videokeratography to differentiate mild keratoconus subtypes.
Article in Journal of refractive surgery (Thorofare, N.J. : 1995), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 42 citations in OpenAlex.
- Value of corneal epithelial and Bowman's layer vertical thickness profiles generated by UHR-OCT for sub-clinical keratoconus diagnosis.Scientific reports · 2016Trial
- Motion-Tracking Brillouin Microscopy for Keratoconus Suspect Identification: Comparison With Multimodal Corneal Imaging.American journal of ophthalmology · 2026Article
- Development and Validation of the Relational Tissue Altered (RTA) Index: Applied Artificial Intelligence for the Assessment of Structural Impact from Laser Vision Correction.Ophthalmology and therapy · 2025Article
- Detection of Corneal Ectasia Using OCT Maps of Pachymetry and Posterior Surface Mean Curvature.Journal of refractive surgery (Thorofare, N.J. : 1995) · 2022Article
- EMKLAS: A New Automatic Scoring System for Early and Mild Keratoconus Detection.Translational vision science & technology · 2020Article
- Distinguishing Highly Asymmetric Keratoconus Eyes Using Dual Scheimpflug/Placido Analysis.American journal of ophthalmology · 2019Article
- Distinguishing Highly Asymmetric Keratoconus Eyes Using Combined Scheimpflug and Spectral-Domain OCT Analysis.Ophthalmology · 2018Article
- Characteristic of entire corneal topography and tomography for the detection of sub-clinical keratoconus with Zernike polynomials using Pentacam.Scientific reports · 2017Article
- Topography and Higher Order Corneal Aberrations of the Fellow Eye in Unilateral Keratoconus.Turkish journal of ophthalmology · 2017Article
- Contact Lenses for Keratoconus- Current Practice.The open ophthalmology journal · 2017Article
- Corneal Biomechanics in Ectatic Diseases: Refractive Surgery Implications.The open ophthalmology journal · 2017Article
- Ectasia risk factors in refractive surgery.Clinical ophthalmology (Auckland, N.Z.) · 2016Review
- Comparison of objective and subjective refractive surgery screening parameters between regular and high-resolution Scheimpflug imaging devices.Journal of cataract and refractive surgery · 2015Article
- A review of corneal imaging methods for the early diagnosis of pre-clinical Keratoconus.Journal of optometryReview
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
purposeTo develop parameters using a combination of optical coherence tomography (OCT) and videokeratography to detect early keratoconus.
methodsVideokeratography, wavefront analysis, and measured OCT indices were performed on 180 normal eyes, 46 eyes with moderate keratoconus, 54 eyes with early keratoconus, 7 eyes with forme fruste keratoconus, and 16 eyes with keratoconus "suspect" to determine the most sensitive parameters for separating these groups.
resultsA combination of videokeratography and OCT indices (inferior-superior [I-S] value and minimum pachymetry) was statistically the most significant in separating the keratoconus groups from normal eyes (P < .001). Using a newly derived index, the minimum pachymetry divided by the I-S value (pachymetry/asymmetry [PA]/I-S index) with a cut-off of 100, 100% of early and forme fruste keratoconus could be identified as being abnormal with 7 normals misclassified (misclassification rate 2.7%). By adding keratoconus "suspect" to the analysis and an I-S value of 1.2 as a cut-off point, 5 "suspects" were classified as normal and 11 normals as abnormal (misclassification rate 7.8%). The PA/I-S index, with a cut-off point of 100, reduced this misclassification rate to 4.4%.
conclusionsThese results suggest that OCT combined with videokeratography may be more useful for differentiating mild forms of keratoconus than videokeratography alone.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.