ArticleHaematologica2014
Analysis of 339 pregnancies in 181 women with 13 different forms of inherited thrombocytopenia.
Open access · goldAbstract readMulticenter Study
In one paragraph
Article in Haematologica, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 2 pooled it
4.8field-weighted citation impact, top 4% of its field
What it found
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The trial behind it
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Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- Menstrual and obstetrical bleeding in women with inherited platelet receptor defects-A systematic review.Haemophilia : the official journal of the World Federation of Hemophilia · 2020Pooled it
- Use of platelet transfusions prior to lumbar punctures or epidural anaesthesia for the prevention of complications in people with thrombocytopenia.The Cochrane database of systematic reviews · 2018Pooled it
- Clinical and Genetic Characterization of 269 Patients With Suspected Inherited Platelet Disorders: The Padua Monocentric Experience.International journal of laboratory hematology · 2026Article
- Inherited Platelet Disorders During Pregnancy and Delivery: Overview of Management Strategies and Emerging Therapeutic Considerations.Hematology reports · 2026Review
- Pregnancy outcomes among women with inherited bleeding disorders: A matched case-control study.SAGE open medicine · 2026Article
- Management of pregnancy and childbirth in Glanzmann thrombasthenia: A case series and review.British journal of haematology · 2025Review
- Implementation and clinical utility of multigene panels for bleeding, platelet, and thrombotic disorders.Journal of thrombosis and haemostasis : JTH · 2025Review
- Point-of-Care Testing in Patients with Hereditary Disorders of Primary Hemostasis: A Narrative Review.Seminars in thrombosis and hemostasis · 2025Review
- Isolated thrombocytopenia in pregnancy: A monocentric retrospective study of 63 pregnancies in 59 women.EJHaem · 2024Article
- Review
- Pathophysiology, Clinical Manifestations and Diagnosis of Immune Thrombocytopenia: Contextualization from a Historical Perspective.Hematology reports · 2024Review
- Reproductive Tract Bleeding in Adolescent and Young Adult Females with Inherited Bleeding Disorders: An Underappreciated Problem.Journal of pediatric and adolescent gynecology · 2022Review
- Platelet dysfunction in platelet-type von Willebrand disease due to the constitutive triggering of the Lyn-PECAM1 inhibitory pathway.Haematologica · 2022Article
- Treatment of inherited thrombocytopenias.Haematologica · 2022Review
- Assessment of post-partum haemorrhage risk among women with moderate thrombocytopenia.British journal of haematology · 2022Article
- Prevalence, burden and treatment effects of vaginal bleeding in women with (suspected) congenital platelet disorders throughout life: a cross-sectional study.British journal of haematology · 2022Article
- The curious incident of a cavum velum interpositum cyst in twins of a mother carrying May-Hegglin anomaly: a case report and short literature review.BMC pregnancy and childbirth · 2020Review
- Inherited thrombocytopenias: history, advances and perspectives.Haematologica · 2020Review
- Antithrombotic prophylaxis for surgery-associated venous thromboembolism risk in patients with inherited platelet disorders. The SPATA-DVT Study.Haematologica · 2020Article
- Platelet Counting: Ugly Traps and Good Advice. Proposals from the French-Speaking Cellular Hematology Group (GFHC).Journal of clinical medicine · 2020Review
Corrections and comments
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Authors and funding
66 authors at 20 institutions in 8 countries.
Patrizia NorisDepartment of Internal Medicine, University of Pavia-IRCCS Policlinico San Matteo Foundation, Italy.
Nicole SchlegelNational Reference Centre on Inherited Platelet Disorders and Service d'Hématologie Biologique, CHU Robert Debré and Paris 7 Denis Diderot University, Paris, France.
Catherine KlersyService of Biometry and Statistics, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.
Paula G HellerInstitute of Medical Research Alfredo Lanari, University of Buenos Aires, Argentina.
Elisa CivaschiDepartment of Internal Medicine, University of Pavia-IRCCS Policlinico San Matteo Foundation, Italy.
Nuria Pujol-MoixUniversitat Autònoma de Barcelona, Institut de Recerca Biomèdica Sant Pau, Spain.
Fabrizio FabrisDepartment of Medicine-DIMED, University of Padova Medical School, Italy.
Remi FavierAP-HP, Armand Trousseau Children's Hospital, Haematological Laboratory, French Reference Center for Inherited Platelet disorders, Paris, France Inserm UMR1009, Villejuif, France.
Paolo GreseleDepartment of Internal Medicine, University of Perugia, Italy.
Véronique Latger-CannardCentre de Compétence Nord-Est des Pathologies Plaquettaires from the frame of the Reference French Centre, France Service d'Hématologie Biologique, Centre Hospitalo-Universitaire, Nancy, France.
Adam CukerDepartment of Medicine and Department of Pathology & Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Paquita NurdenPlateforme Technologique et d'Innovation Biomédicale, Hôpital Xavier Arnozan, Pessac, France.
Andreas GreinacherInstitut für Immunologie und Transfusionsmedizin, Greifswald, Germany.
Marco CattaneoMedicina III, Ospedale San Paolo, Dipartimento di Scienze della Salute, Università degli Studi di Milano, Italy.
Erica De CandiaServizio Malattie Emorragiche e Trombotiche, Istituto di Medicina Interna e Geriatria, Policlinico Agostino Gemelli, Università Cattolica del Sacro Cuore, Roma, Italy.
Alessandro PecciDepartment of Internal Medicine, University of Pavia-IRCCS Policlinico San Matteo Foundation, Italy.
Marie-Françoise Hurtaud-RouxNational Reference Centre on Inherited Platelet Disorders and Service d'Hématologie Biologique, CHU Robert Debré and Paris 7 Denis Diderot University, Paris, France.
Ana C GlembotskyInstitute of Medical Research Alfredo Lanari, University of Buenos Aires, Argentina.
Eduardo Muñiz-DiazImmunohematology Department, Banc de Sang i Teixits de Catalunya, Barcelona, Spain.
Maria Luigia RandiDepartment of Medicine-DIMED, University of Padova Medical School, Italy.
Nathalie TrillotInstitut d'Hématologie-Transfusion, Pôle Biologie Pathologie Génétique, CHRU, Lille, France.
Loredana BuryDepartment of Internal Medicine, University of Perugia, Italy.
Thomas LecompteDépartement des Spécialités de Médecine, Service d'Hématologie, Hôpitaux Universitaires de Genève, Suisse Université de Genève, Faculté de Médecine, Suisse.
Caterina MarconiGenetica Medica, Dipartimento di Scienze Mediche Chirurgiche, Policlinico Sant'Orsola-Malpighi, University of Bologna, Italy.
Anna SavoiaDepartment of Medical Sciences, University of Trieste, Italy Institute for Maternal and Child Health - IRCCS Burlo Garofolo, Trieste, Italy.
Carlo L BalduiniDepartment of Internal Medicine, University of Pavia-IRCCS Policlinico San Matteo Foundation, Italy c.balduini@smatteo.pv.it.
Sophie BayartService d'Hémostase Bio-Clinique, Centre Régional de traitement des maladies hémorragiques de Rennes-Bretagne, CHU de Rennes, Rennes, France.
Anne BautersInstitut d'Hématologie-Transfusion, Pôle Biologie Pathologie Génétique, CHRU Lille, France.
Schéhérazade Benabdallah-GuediraUniversité Mohamed V Rabat, Faculté de Médecine et de Pharmacie, Hôpital Avicenne, Rabat, Morocco.
Françoise BoehlenDivision of Angiology and Haemostasis, Department of Medical Specialisations, Faculty of Medicine and University Hospitals of Geneva, Geneva, Switzerland Geneva Platelet Group, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Jeanne-Yvonne BorgCHU Charles Nicolle, Unité Hémostase-Hématologie, Rouen, France.
Roberta BottegaInstitute for Maternal and Child Health - IRCCS Burlo Garofolo, Trieste, Italy.
James BusselWeill Medical College of Cornell University, New York, NY, USA.
Daniela De RoccoDepartment of Medical Sciences, University of Trieste, Trieste, Italy.
Emmanuel de MaistreService d'hématologie Biologie, Centre Hospitalo-Universitaire Dijon, France.
Michela FaleschiniDepartment of Medical Sciences, University of Trieste, Trieste, Italy.
Emanuela FalcinelliDepartment of Internal Medicine, University of Perugia, Perugia, Italy.
Silvia FerrariDepartment of Medicine-DIMED; University of Padova Medical School, Padova, Italy.
Alina FersterUnité d'Hémato-Oncologie pédiatrique, Hôpital Universitaire des Enfants Reine Fabiola, Bruxelles, Belgique.
Tiziana FierroDepartment of Internal Medicine, University of Perugia, Perugia, Italy.
Dominique FleuryService de Néphrologie, CH Valenciennes, Valenciennes, France.
Pierre FontanaDivision of Angiology and Haemostasis, Department of Medical Specialisations, Faculty of Medicine and University Hospitals of Geneva, Geneva, Switzerland Geneva Platelet Group, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Chloé JamesLaboratoire d'Hématologie and National Reference Centre on Inherited Platelet Disorders, CHU Haut Lévêque, Pessac, France.
Francois LanzaINSERM UMR-S949/EFS-Alsace, Strasbourg, France.
Véronique Le Cam DuchezCHU Charles Nicolle, Unité Hémostase-Hématologie, Rouen, France.
Giuseppe LoffredoDepartment of Oncology, Azienda Santobono-Pausilipon, Pausilipon Hospital, Napoli, Italy.
Pamela MaginiGenetica Medica, Dipartimento di Scienze Mediche Chirurgiche, Policlinico Sant'Orsola-Malpighi - University of Bologna, Bologna, Italy.
Dominique Martin-CoignardLaboratoire de Génétique, CH Le Mans, France.
Fanny MenardCentre Hospitalier de la côte basque, Bayonne, France.
Sandra MercierService de Génétique Clinique, Centre de Référence Anomalies du Développement du Grand Ouest, CHU Rennes-Hôpital Sud, Rennes, France.
Annamaria MezzasomaDepartment of Internal Medicine, University of Perugia, Perugia, Italy.
Pietro MinuzDepartment of Medicine and Haematology, University Hospital of Verona, Verona, Italy.
Ilaria NicheleDepartment of Cell Therapy and Hematology, San Bortolo Hospital, Vicenza, Italy.
Lucia D NotarangeloDepartment of Pediatrics, University of Brescia, Brescia, Italy.
Tommaso PippucciGenetica Medica, Dipartimento di Scienze Mediche Chirurgiche, Policlinico Sant'Orsola-Malpighi - University of Bologna, Bologna, Italy.
Gian Marco PoddaMedicina III, Ospedale San Paolo, Dipartimento di Scienze della Salute, Università degli Studi di Milano, Italy.
Catherine PouymayouLaboratoire d'Hématologie and National Reference Centre on Inherited Platelet Disorders, CHU La Timone, Marseille, France.
Agnes RigouzzoAP-HP, Armand Trousseau children Hospital, Department of Anesthesiology, Paris, France.
Bruno RoyerHématologie clinique et thérapie cellulaire, CHU Amiens, France.
Pierre SieLaboratoire d'Hématologie and National Reference Centre of Inherited Platelet Disorders, CHU Rangueil, Toulouse, France.
Virginie SiguretService d' Hématologie Biologique, CHU Hôpital Européen Georges Pompidou, Paris, France.
Catherine TrichetService de Biologie Clinique Secteur Hématologie, CH Victor Dupouy, Argenteuil, France.
Alessandra TucciHematology Unit, Spedali Civili Hospital and University of Brescia, Brescia, Italy.
Béatrice SaposnikNational Reference Centre on Inherited Platelet Disorders and Service d'Hématologie Biologique, CHU Robert Debré and Paris 7 Denis Diderot University, Paris, France.
Dino VeneriDepartment of Medicine and Haematology, University Hospital of Verona, Verona, Italy.
European Hematology Association – Scientific Working Group on Thrombocytopenias and Platelet Function Disorders
University of Perugia · ITUniversity of Pavia · ITIRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola · ITUniversité Paris Cité · FRUniversity of Geneva · CHUniversity of Padua · ITUniversity of Trieste · ITCentre Hospitalier Universitaire de Rennes · FRHôpital Charles-Nicolle · FRInserm · FRInstitut d’Hématologie et d’Oncologie Pédiatrique · FRUniversidad de Buenos Aires · ARUniversity of Milan · ITUniversity of Verona · ITAzienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · ITBanc de Sang i Teixits · ESCentre Hospitalier de la Côte Basque · FRCentre Hospitalier de Valenciennes · FRCentre Hospitalier du Mans · FRCentre Hospitalier Victor Dupouy · FR
Funding
Telethon GGP10089
Abstract
Pregnancy in women with inherited thrombocytopenias is a major matter of concern as both the mothers and the newborns are potentially at risk of bleeding. However, medical management of this condition cannot be based on evidence because of the lack of consistent information in the literature. To advance knowledge on this matter, we performed a multicentric, retrospective study evaluating 339 pregnancies in 181 women with 13 different forms of inherited thrombocytopenia. Neither the degree of thrombocytopenia nor the severity of bleeding tendency worsened during pregnancy and the course of pregnancy did not differ from that of healthy subjects in terms of miscarriages, fetal bleeding and pre-term births. The degree of thrombocytopenia in the babies was similar to that in the mother. Only 7 of 156 affected newborns had delivery-related bleeding, but 2 of them died of cerebral hemorrhage. The frequency of delivery-related maternal bleeding ranged from 6.8% to 14.2% depending on the definition of abnormal blood loss, suggesting that the risk of abnormal blood loss was increased with respect to the general population. However, no mother died or had to undergo hysterectomy to arrest bleeding. The search for parameters predicting delivery-related bleeding in the mother suggested that hemorrhages requiring blood transfusion were more frequent in women with history of severe bleedings before pregnancy and with platelet count at delivery below 50 × 10(9)/L.
Indexed as
AdultFemaleHumansInfant, NewbornPregnancyPregnancy Complications, HematologicRetrospective StudiesThrombocytopeniaYoung Adult
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