Evidence map›Paper›PMID 24763370›Full record

Trial reportThe ISME journal2014

Impact of diet and individual variation on intestinal microbiota composition and fermentation products in obese men.

Anne Salonen, Leo Lahti, Jarkko Salojärvi, Grietje Holtrop, Katri Korpela, Sylvia H Duncan, Priya Date, Freda Farquharson, Alexandra M Johnstone, Gerald E Lobley and 3 more

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The ISME journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03141710 (Effect of Prebiotic in Type 2 Diabetes), which is not on this map. Cited by 332 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
332citing papers in PubMed, 5 pooled it
16.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03141710 nacompletednot on this mapstarted 2017, after this paper: background citation

Effect of Prebiotic in Type 2 Diabetes (Diabetes and Health Study)

TypeinterventionalSponsorUniversity of AberdeenRan2017 to 2017Enrolled12ConditionsDiabetes Mellitus, Type 2Arms20 ml of prebiotic per day
3 · Its place in the literature

Who cites it

332 citing papers in PubMed, 5 syntheses or guidelines pooled it, 618 citations in OpenAlex.

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272 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

Anne SalonenImmunobiology Research Program, Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Helsinki, Finland.
Leo Lahti1] Laboratory of Microbiology, Wageningen University, Wageningen, The Netherlands [2] Department of Veterinary Biosciences, University of Helsinki, Helsinki, Finland.
Jarkko SalojärviDepartment of Veterinary Biosciences, University of Helsinki, Helsinki, Finland.
Grietje HoltropBiomathematics and Statistics Scotland, Aberdeen, UK.
Katri KorpelaImmunobiology Research Program, Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Helsinki, Finland.
Sylvia H DuncanRowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, UK.
Priya DateRowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, UK.
Freda FarquharsonRowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, UK.
Alexandra M JohnstoneRowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, UK.
Gerald E LobleyRowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, UK.
Petra LouisRowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, UK.
Harry J FlintRowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, UK.
Willem M de Vos1] Immunobiology Research Program, Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Helsinki, Finland [2] Laboratory of Microbiology, Wageningen University, Wageningen, The Netherlands [3] Department of Veterinary Biosciences, University of Helsinki, Helsinki, Finland.
University of Aberdeen · GBUniversity of Helsinki · FIBiomathematics and Statistics Scotland · GBWageningen University & Research · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is growing interest in understanding how diet affects the intestinal microbiota, including its possible associations with systemic diseases such as metabolic syndrome. Here we report a comprehensive and deep microbiota analysis of 14 obese males consuming fully controlled diets supplemented with resistant starch (RS) or non-starch polysaccharides (NSPs) and a weight-loss (WL) diet. We analyzed the composition, diversity and dynamics of the fecal microbiota on each dietary regime by phylogenetic microarray and quantitative PCR (qPCR) analysis. In addition, we analyzed fecal short chain fatty acids (SCFAs) as a proxy of colonic fermentation, and indices of insulin sensitivity from blood samples. The diet explained around 10% of the total variance in microbiota composition, which was substantially less than the inter-individual variance. Yet, each of the study diets induced clear and distinct changes in the microbiota. Multiple Ruminococcaceae phylotypes increased on the RS diet, whereas mostly Lachnospiraceae phylotypes increased on the NSP diet. Bifidobacteria decreased significantly on the WL diet. The RS diet decreased the diversity of the microbiota significantly. The total 16S ribosomal RNA gene signal estimated by qPCR correlated positively with the three major SCFAs, while the amount of propionate specifically correlated with the Bacteroidetes. The dietary responsiveness of the individual's microbiota varied substantially and associated inversely with its diversity, suggesting that individuals can be stratified into responders and non-responders based on the features of their intestinal microbiota.

Indexed as

MicrobiotaAdultAgedBacteriaCross-Over StudiesDiet, ReducingFatty Acids, VolatileFecesFermentationHumansIntestinesMaleMetabolic SyndromeMiddle AgedObesityPhylogenyFatty Acids, Volatile

Identifiers

PMID24763370
PMCPMC4992075
OpenAlexW2031355202

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.