ArticleThe ISME journal2014
Anaerobic oxidation of long-chain n-alkanes by the hyperthermophilic sulfate-reducing archaeon, Archaeoglobus fulgidus.
Article in The ISME journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 94 citations in OpenAlex.
- Nature's Anaerobic Toolkit: Glycyl Radical Enzymes and Their Expanding Functional and Mechanistic Diversity.Biochemistry · 2026Review
- Sulfidic toluene mineralization by aquifer microbial communities at different temperatures.FEMS microbiology ecology · 2025Article
- Maintaining ocean ecosystem health with hydrocarbonoclastic microbes.ISME communications · 2025Review
- Anaerobic hexadecane degradation by a thermophilic Hadarchaeon from Guaymas Basin.The ISME journal · 2024Article
- Influence of Extremely High Pressure and Oxygen on Hydrocarbon-Enriched Microbial Communities in Sediments from the Challenger Deep, Mariana Trench.Microorganisms · 2023Article
- Metabolic profiling of petroleum-degrading microbial communities incubated under high-pressure conditions.Frontiers in microbiology · 2023Article
- Geological processes mediate a microbial dispersal loop in the deep biosphere.Science advances · 2022Article
- A Structural View of Alkyl-Coenzyme M Reductases, the First Step of Alkane Anaerobic Oxidation Catalyzed by Archaea.Biochemistry · 2022Review
- A review on microbial diversity and genetic markers involved in methanogenic degradation of hydrocarbons: futuristic prospects of biofuel recovery from contaminated regions.Environmental science and pollution research international · 2021Review
- Newly discovered Asgard archaea Hermodarchaeota potentially degrade alkanes and aromatics via alkyl/benzyl-succinate synthase and benzoyl-CoA pathway.The ISME journal · 2021Article
- CANT-HYD: A Curated Database of Phylogeny-Derived Hidden Markov Models for Annotation of Marker Genes Involved in Hydrocarbon Degradation.Frontiers in microbiology · 2021Article
- Physiological and Genomic Characterization of a Hyperthermophilic ArchaeonFrontiers in microbiology · 2021Article
- Microbial Sulfur Isotope Fractionation in the Chicxulub Hydrothermal System.Astrobiology · 2021Article
- Deciphering the archaeal communities in tree rhizosphere of the Qinghai-Tibetan plateau.BMC microbiology · 2020Article
- Protective Role of Bacterial Alkanesulfonate Monooxygenase under Oxidative Stress.Applied and environmental microbiology · 2020Article
- Novel clostridial lineages recovered from metagenomes of a hot oil reservoir.Scientific reports · 2020Article
- Long-chain n-alkane biodegradation coupling to methane production in an enriched culture from production water of a high-temperature oil reservoir.AMB Express · 2020Article
- Rate and Extent of Growth of a Model Extremophile,Frontiers in microbiology · 2020Article
- Insights into the ecological roles and evolution of methyl-coenzyme M reductase-containing hot spring Archaea.Nature communications · 2019Article
- Methanogenic Degradation of LongApplied and environmental microbiology · 2019Article
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The thermophilic sulfate-reducing archaeon Archaeoglobus fulgidus strain VC-16 (DSM 4304), which is known to oxidize fatty acids and n-alkenes, was shown to oxidize saturated hydrocarbons (n-alkanes in the range C10-C21) with thiosulfate or sulfate as a terminal electron acceptor. The amount of n-hexadecane degradation observed was in stoichiometric agreement with the theoretically expected amount of thiosulfate reduction. One of the pathways used by anaerobic microorganisms to activate alkanes is addition to fumarate that involves alkylsuccinate synthase as a key enzyme. A search for genes encoding homologous enzymes in A. fulgidus identified the pflD gene (locus-tag AF1449) that was previously annotated as a pyruvate formate lyase. A phylogenetic analysis revealed that this gene is of bacterial origin and was likely acquired by A. fulgidus from a bacterial donor through a horizontal gene transfer. Based on three-dimensional modeling of the corresponding protein and molecular dynamic simulations, we hypothesize an alkylsuccinate synthase activity for this gene product. The pflD gene expression was upregulated during the growth of A. fulgidus on an n-alkane (C16) compared with growth on a fatty acid. Our results suggest that anaerobic alkane degradation in A. fulgidus may involve the gene pflD in alkane activation through addition to fumarate. These findings highlight the possible importance of hydrocarbon oxidation at high temperatures by A. fulgidus in hydrothermal vents and the deep biosphere.
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