Evidence map›Paper›PMID 24763185›Full record

ArticleEpidemiology and infection2015

Community-associated methicillin-resistant Staphylococcus aureus transmission in households of infected cases: a pooled analysis of primary data from three studies across international settings.

J Knox, M Van Rijen, A-C Uhlemann, M Miller, C Hafer, P Vavagiakis, Q Shi, P D R Johnson, G Coombs, M Kluytmans-Van Den Bergh and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epidemiology and infection, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

J KnoxDivision of Infectious Diseases, Department of Medicine,Columbia University,College of Physicians & Surgeons, New York,USA.
M Van RijenAmphia Hospital,Breda,The Netherlands.
A-C UhlemannDivision of Infectious Diseases, Department of Medicine,Columbia University,College of Physicians & Surgeons, New York,USA.
M MillerDepartment of Epidemiology, Mailman School of Public Health,Columbia University;New York,USA.
C HaferDivision of Infectious Diseases, Department of Medicine,Columbia University,College of Physicians & Surgeons, New York,USA.
P VavagiakisPanna Technologies,New York,USA.
Q ShiDepartment of Epidemiology and Community Health, School of Health Sciences and Practice,New York Medical College,Valhalla,USA.
P D R JohnsonAustin Health,Melbourne, Victoria,Australia.
G CoombsAustralian Collaborating Centre for Enterococcus and Staphylococcus Species (ACCESS) Typing and Research, School of Biomedical Sciences,Curtin University,Perth, Western Australia,Australia.
M Kluytmans-Van Den BerghAmphia Hospital,Breda,The Netherlands.
J KluytmansAmphia Hospital,Breda,The Netherlands.
C M BennettDeakin University,Melbourne, Victoria,Australia.
F D LowyDivision of Infectious Diseases, Department of Medicine,Columbia University,College of Physicians & Surgeons, New York,USA.

Funding

Modeling of S.Aureus Transmission in Northern ManhattanR01AI077690 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LOWY, FRANKLIN D · 2009 to 2013
$3.4M
Mechanisms of S. aureus transmission and persistence.K08AI090013 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI UHLEMANN, ANNE-CATRIN · 2010 to 2014
$655k
NIAID NIH HHS AI077690NIAID NIH HHS AI090013NIAID NIH HHS K08 AI090013NIAID NIH HHS R01 AI077690
6 · The paper itself

Abstract

Diverse strain types of methicillin-resistant Staphylococcus aureus (MRSA) cause infections in community settings worldwide. To examine heterogeneity of spread within households and to identify common risk factors for household transmission across settings, primary data from studies conducted in New York (USA), Breda (The Netherlands), and Melbourne (Australia) were pooled. Following MRSA infection of the index patient, household members completed questionnaires and provided nasal swabs. Swabs positive for S. aureus were genotyped by spa sequencing. Poisson regression with robust error variance was used to estimate prevalence odds ratios for transmission of the clinical isolate to non-index household members. Great diversity of strain types existed across studies. Despite differences between studies, the index patient being colonized with the clinical isolate at the home visit (P < 0·01) and the percent of household members aged <18 years (P < 0·01) were independently associated with transmission. Targeted decolonization strategies could be used across geographical settings to limit household MRSA transmission.

Indexed as

Community-Acquired InfectionsMethicillin-Resistant Staphylococcus aureusStaphylococcal InfectionsAdolescentAdultAustraliaChildChild, PreschoolFamily CharacteristicsFemaleHumansInfantMaleNetherlandsNew YorkRetrospective Studies

Identifiers

PMID24763185
PMCPMC4981654

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.