Evidence map›Paper›PMID 24763138›Full record

ArticleScientific reports2014

Genomic analysis of the blood attributed to Louis XVI (1754-1793), king of France.

Iñigo Olalde, Federico Sánchez-Quinto, Debayan Datta, Urko M Marigorta, Charleston W K Chiang, Juan Antonio Rodríguez, Marcos Fernández-Callejo, Irene González, Magda Montfort, Laura Matas-Lalueza and 9 more

Abstract read
In one paragraph

Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Metagenomic analysis of a blood stain from the French revolutionary Jean-Paul Marat (1743-1793).Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2020
    Article
  2. Article
  3. Review
  4. Toward high-resolution population genomics using archaeological samples.DNA research : an international journal for rapid publication of reports on genes and genomes · 2016
    Review
  5. Re-inventing ancient human DNA.Investigative genetics · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Iñigo OlaldeInstitute of Evolutionary Biology (CSIC-Universitat Pompeu Fabra), Dr. Aiguader 88, 08003 Barcelona, Spain.
Federico Sánchez-QuintoInstitute of Evolutionary Biology (CSIC-Universitat Pompeu Fabra), Dr. Aiguader 88, 08003 Barcelona, Spain.
Debayan Datta1] Centre for Genomic Regulation (CRG) and Universitat Pompeu Fabra (UPF), Dr. Aiguader 88, 08003 Barcelona, Spain [2] Universitat Pompeu Fabra (UPF), Dr. Aiguader 88, 08003 Barcelona, Spain.
Urko M MarigortaInstitute of Evolutionary Biology (CSIC-Universitat Pompeu Fabra), Dr. Aiguader 88, 08003 Barcelona, Spain.
Charleston W K ChiangDepartment of Ecology and Evolutionary Biology, University of California, Los Angeles, 612 Charles E.Young Drive South, Los Angeles, California, USA.
Juan Antonio RodríguezInstitute of Evolutionary Biology (CSIC-Universitat Pompeu Fabra), Dr. Aiguader 88, 08003 Barcelona, Spain.
Marcos Fernández-CallejoInstitute of Evolutionary Biology (CSIC-Universitat Pompeu Fabra), Dr. Aiguader 88, 08003 Barcelona, Spain.
Irene González1] Centre for Genomic Regulation (CRG) and Universitat Pompeu Fabra (UPF), Dr. Aiguader 88, 08003 Barcelona, Spain [2] Universitat Pompeu Fabra (UPF), Dr. Aiguader 88, 08003 Barcelona, Spain.
Magda Montfort1] Centre for Genomic Regulation (CRG) and Universitat Pompeu Fabra (UPF), Dr. Aiguader 88, 08003 Barcelona, Spain [2] Universitat Pompeu Fabra (UPF), Dr. Aiguader 88, 08003 Barcelona, Spain.
Laura Matas-LaluezaInstitute of Evolutionary Biology (CSIC-Universitat Pompeu Fabra), Dr. Aiguader 88, 08003 Barcelona, Spain.
Sergi CivitDepartament d'Estadstica, Universitat de Barcelona, 08028 Barcelona, Spain.
Donata LuiselliDepartment of Biological, Geological and Environmental Sciences, Lab. of Molecular Anthropology, Universit di Bologna, Via Selmi 3, 40126 Bologna, Italy.
Philippe CharlierLaboratory of Medical and Forensic Anthropology, UFR des Sciences de la Sant, 78180 Montigny-le-Bretonneux, Paris, France.
Davide PettenerDepartment of Biological, Geological and Environmental Sciences, Lab. of Molecular Anthropology, Universit di Bologna, Via Selmi 3, 40126 Bologna, Italy.
Oscar RamírezInstitute of Evolutionary Biology (CSIC-Universitat Pompeu Fabra), Dr. Aiguader 88, 08003 Barcelona, Spain.
Arcadi Navarro1] Institute of Evolutionary Biology (CSIC-Universitat Pompeu Fabra), Dr. Aiguader 88, 08003 Barcelona, Spain [2] Instituci Catalana de Recerca i Estudis Avanats (ICREA), 08010 Barcelona, Spain [3] Centre de Regulaci Genmica (CRG), Barcelona 08003, Spain [4] National Institute for Bioinformatics (INB), Barcelona 08003, Spain.
Heinz Himmelbauer1] Centre for Genomic Regulation (CRG) and Universitat Pompeu Fabra (UPF), Dr. Aiguader 88, 08003 Barcelona, Spain [2] Universitat Pompeu Fabra (UPF), Dr. Aiguader 88, 08003 Barcelona, Spain.
Tomàs Marquès-Bonet1] Institute of Evolutionary Biology (CSIC-Universitat Pompeu Fabra), Dr. Aiguader 88, 08003 Barcelona, Spain [2] Instituci Catalana de Recerca i Estudis Avanats (ICREA), 08010 Barcelona, Spain [3] CNAG (Centro Nacional de Analisis Genomico), 08028 Barcelona, Spain.
Carles Lalueza-FoxInstitute of Evolutionary Biology (CSIC-Universitat Pompeu Fabra), Dr. Aiguader 88, 08003 Barcelona, Spain.

Funding

European Research Council 260372
6 · The paper itself

Abstract

A pyrographically decorated gourd, dated to the French Revolution period, has been alleged to contain a handkerchief dipped into the blood of the French king Louis XVI (1754-1793) after his beheading but recent analyses of living males from two Bourbon branches cast doubts on its authenticity. We sequenced the complete genome of the DNA contained in the gourd at low coverage (~2.5×) with coding sequences enriched at a higher ~7.3× coverage. We found that the ancestry of the gourd's genome does not seem compatible with Louis XVI's known ancestry. From a functional perspective, we did not find an excess of alleles contributing to height despite being described as the tallest person in Court. In addition, the eye colour prediction supported brown eyes, while Louis XVI had blue eyes. This is the first draft genome generated from a person who lived in a recent historical period; however, our results suggest that this sample may not correspond to the alleged king.

Indexed as

DNAGenome, HumanGenomicsAllelesDNA ContaminationExomeForensic GeneticsFranceHumansMetagenomicsPhenotypePolymorphism, Single NucleotideQuantitative Trait, HeritableDNA

Identifiers

PMID24763138
PMCPMC3998215

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.