ReviewNutrients2014
Ascorbic acid and the brain: rationale for the use against cognitive decline.
Review in Nutrients, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed.
- Trial
- Rewinding the Clock: Emerging Pharmacological Strategies for Human Anti-Aging Therapy.International journal of molecular sciences · 2025Review
- Review
- Harnessing the fundamental roles of vitamins: the potent anti-oxidants in longevity.Biogerontology · 2025Review
- Review
- Protective signature of xanthohumol on cognitive function of APP/PS1 mice: a urine metabolomics approach by age.Frontiers in pharmacology · 2024Article
- Association of cardiovascular health with cognitive function and the mediating effect of depressive state.Frontiers in aging neuroscience · 2024Article
- Glutathione-Mediated Neuroprotective Effect of Purine Derivatives.International journal of molecular sciences · 2023Review
- Brain Trauma and the Secondary Cascade in Humans: Review of the Potential Role of Vitamins in Reparative Processes and Functional Outcome.Behavioral sciences (Basel, Switzerland) · 2023Review
- Ascorbic acid does not necessarily interfere with the electrochemical detection of dopamine.Scientific reports · 2022Article
- The Role of Kiwifruit in Supporting Psychological Well-Being: A Rapid Review of the Literature.Nutrients · 2022Review
- Immune System and Psychological State of Pregnant Women during COVID-19 Pandemic: Are Micronutrients Able to Support Pregnancy?Nutrients · 2022Review
- Ascorbic Acid Deficiency Prevalence and Associated Cognitive Impairment in Alcohol Detoxification Inpatients: A Pilot Study.Antioxidants (Basel, Switzerland) · 2021Article
- Article
- Selected Micronutrients: An Option to Boost Immunity against COVID-19 and Prevent Adverse Pregnancy Outcomes in Pregnant Women: A Narrative Review.Iranian journal of public health · 2020Review
- Seizure-Induced Oxidative Stress in Status Epilepticus: Is Antioxidant Beneficial?Antioxidants (Basel, Switzerland) · 2020Review
- A Cecal Slurry Mouse Model of Sepsis Leads to Acute Consumption of Vitamin C in the Brain.Nutrients · 2020Article
- Specific Nutrient Intake Via Diet and/or Supplementation in Relation to Female Stress: A Cross-Sectional Study.Women's health reports (New Rochelle, N.Y.) · 2020Article
- On the physiological and cellular homeostasis of ascorbate.Cellular & molecular biology letters · 2020Review
- Adding an orange to the banana bag: vitamin C deficiency is common in alcohol use disorders.Critical care (London, England) · 2019Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
This review is focused upon the role of ascorbic acid (AA, vitamin C) in the promotion of healthy brain aging. Particular attention is attributed to the biochemistry and neuronal metabolism interface, transport across tissues, animal models that are useful for this area of research, and the human studies that implicate AA in the continuum between normal cognitive aging and age-related cognitive decline up to Alzheimer's disease. Vascular risk factors and comorbidity relationships with cognitive decline and AA are discussed to facilitate strategies for advancing AA research in the area of brain health and neurodegeneration.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.