ArticleCell death & disease2014
Attenuation of noise-induced hearing loss using methylene blue.
Article in Cell death & disease, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Thiol-Disulfide Homeostasis in Noise-Induced Hearing Loss in Rats.The journal of international advanced otology · 2024Article
- CFTR potentiator ivacaftor protects against noise-induced hair cell loss by increasing Nrf2 and reducing oxidative stress.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2023Article
- Multifunctional Redox Modulators Protect Auditory, Visual, and Cognitive Function.Antioxidants & redox signaling · 2022Article
- Nitrative Stress and Auditory Dysfunction.Pharmaceuticals (Basel, Switzerland) · 2022Review
- mito-TEMPO Attenuates Oxidative Stress and Mitochondrial Dysfunction in Noise-Induced Hearing LossFrontiers in cellular neuroscience · 2022Article
- Noise-Induced Hearing Loss: Updates on Molecular Targets and Potential Interventions.Neural plasticity · 2021Review
- Effect of myricetin on the gene expressions of NOX3, TGF-β1, prestin, and HSP-70 and anti-oxidant activity in the cochlea of noise-exposed rats.Iranian journal of basic medical sciences · 2020Article
- Mitochondrial Dysfunction and Therapeutic Targets in Auditory Neuropathy.Neural plasticity · 2020Review
- Pre-exposure to Lower-Level Noise Mitigates Cochlear Synaptic Loss Induced by High-Level Noise.Frontiers in systems neuroscience · 2020Article
- Novel QUEST MRI In Vivo Measurement of Noise-induced Oxidative Stress in the Cochlea.Scientific reports · 2019Article
- Hyperbaric Oxygen Treatment Ameliorates Hearing Loss and Auditory Cortex Injury in Noise Exposed Mice by Repressing Local Ceramide Accumulation.International journal of molecular sciences · 2019Article
- Outer hair cells isolation from postnatal Sprague-Dawley rats.World journal of otorhinolaryngology - head and neck surgery · 2019Article
- Nfatc4 Deficiency Attenuates Ototoxicity by Suppressing Tnf-Mediated Hair Cell Apoptosis in the Mouse Cochlea.Frontiers in immunology · 2019Article
- AAV-mediated NT-3 overexpression protects cochleae against noise-induced synaptopathy.Gene therapy · 2018Article
- CRISPR/Cas9-mediated knockout of Lim-domain only four retards organ of Corti cell growth.Journal of cellular biochemistry · 2018Article
- Environmental exposure to organochlorine pesticides and deficits in cochlear status in children.Environmental science and pollution research international · 2015Article
- Functional distribution of synapsin I in human sperm.FEBS open bio · 2015Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The overproduction of reactive oxygen species (ROS) and reactive nitrogen species (RNS) has been known to contribute to the pathogenesis of noise-induced hearing loss. In this study, we discovered that in BALB/c mice pretreatment with methylene blue (MB) for 4 consecutive days significantly protected against cochlear injury by intense broad-band noise for 3 h. It decreased both compound threshold shift and permanent threshold shift and, further, reduced outer hair cell death in the cochlea. MB also reduced ROS and RNS formation after noise exposure. Furthermore, it protected against rotenone- and antimycin A-induced cell death and also reversed ATP generation in the in vitro UB-OC1 cell system. Likewise, MB effectively attenuated the noise-induced impairment of complex IV activity in the cochlea. In addition, it increased the neurotrophin-3 (NT-3) level, which could affect the synaptic connections between hair cells and spiral ganglion neurons in the noise-exposed cochlea, and also promoted the conservation of both efferent and afferent nerve terminals on the outer and inner hair cells. These findings suggest that the amelioration of impaired mitochondrial electron transport and the potentiation of NT-3 expression by treatment with MB have a significant therapeutic value in preventing ROS-mediated sensorineural hearing loss.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.