Evidence map›Paper›PMID 24762748›Full record

ArticleThe American journal of the medical sciences2014

Risk factors for frailty in a large prevalent cohort of hemodialysis patients.

Nancy G Kutner, Rebecca Zhang, Yijian Huang, William M McClellan, Quinlyn A Soltow, Janice Lea

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of the medical sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 6 pooled it
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 6 syntheses or guidelines pooled it, 49 citations in OpenAlex.

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  8. Frailty in Kidney Disease: A Comprehensive Review to Advance Its Clinical and Research Applications.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Nancy G KutnerDepartment of Rehabilitation Medicine (NGK), Emory University School of Medicine, Atlanta, Georgia; Department of Biostatistics and Bioinformatics (RZ, YH), Rollins School of Public Health, Emory University, Atlanta, Georgia; Department of Medicine (WMM, JL), Division of Nephrology, Emory University School of Medicine, Atlanta, Georgia; Department of Epidemiology (WMM), Rollins School of Public Health, Emory University, Atlanta, Georgia; and Department of Medicine (QAS), Division of Pulmonology, Emory University School of Medicine, Atlanta, Georgia.
Rebecca Zhang
Yijian Huang
William M McClellan
Quinlyn A Soltow
Janice Lea
Emory University · US

Funding

NIDDK NIH HHS HHSN267200715004CNIDDK NIH HHS N01 DK012471NIDDK NIH HHS N01 DK075004NIDDK NIH HHS N01-DK-7-5004
6 · The paper itself

Abstract

backgroundAlthough individuals with kidney disease, including those dependent on dialysis, often present clinically with signs and symptoms consistent with frailty, there is limited information about sociodemographic and clinical risk factors that may be associated.

methodsSeven hundred forty-five patients undergoing hemodialysisbetween 2009 and 2011 in 7 Atlanta dialysis clinics and 7 San Francisco bay area dialysis clinics were assessed using the validated Fried frailty index (recent unintentional weight loss, reported exhaustion, low grip strength, slow walk speed, low physical activity) that defines frailty as the presence of 3 or more criteria. Study coordinators interviewed participants; measured grip strength, walk speed, and body composition; and reviewed records for clinical and laboratory parameters. Logistic regression models were used to estimate the association of patient characteristics with frailty.

resultsIn adjusted analyses, peripheral vascular disease and cardiac diseases, including dysrhythmia, atrial fibrillation, tachycardia, pericarditis, and cardiac arrest, were associated with higher odds for frailty, whereas black race and higher serum albumin concentration were associated with lower odds for frailty.

conclusionsIn multivariable analyses, the risk for frailty in patients undergoing hemodialysis, as assessed by the presence of 3 or more criteria that comprise the Fried frailty index, was increased in association with peripheral vascular disease and cardiac conditions, such as dysrhythmia and atrial fibrillation, and was decreased for those with higher serum albumin concentration and for blacks compared with whites. Among patients who met the Fried definition of frailty, 78% scored as frail on walk speed and 56% scored as frail on grip strength, the 2 physical performance measures.

Indexed as

AdultAgedCardiovascular DiseasesCohort StudiesExerciseFatigueFemaleHand StrengthHumansMaleMiddle AgedMuscle WeaknessObesityPrevalenceRenal DialysisRisk Factors

Identifiers

PMID24762748
PMCPMC4169714
OpenAlexW2060827685

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.