ArticlePLoS genetics2014
The challenges of mitochondrial replacement.
Erratum issuedAbstract readComment
In one paragraph
Article in PLoS genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 43 papers.
0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed.
- The Role of Mitochondrial Regulation in Macrophage Polarization: Implications for the Pathogenesis of Rheumatoid Arthritis.Journal of inflammation research · 2025Review
- Molecular consequences of mitochondrial replacement may be masked from organismal traits in Tigriopus californicus.PloS one · 2025Article
- Mitochondria: A Potential Rejuvenation Tool against Aging.Aging and disease · 2024Review
- Potential Applications of Mitochondrial Therapy with a Focus on Parkinson's Disease and Mitochondrial Transplantation.Advanced pharmaceutical bulletin · 2024Review
- Mitochondrial Transfer as a Novel Therapeutic Approach in Disease Diagnosis and Treatment.International journal of molecular sciences · 2023Review
- Modeling mitochondrial DNA diseases: from base editing to pluripotent stem-cell-derived organoids.EMBO reports · 2023Review
- Mitochondrial transplantation as a promising therapy for mitochondrial diseases.Acta pharmaceutica Sinica. B · 2023Review
- Mitochondrial Transplantation in Mitochondrial Medicine: Current Challenges and Future Perspectives.International journal of molecular sciences · 2023Review
- Investigating the Impact of a Curse: Diseases, Population Isolation, Evolution and the Mother's Curse.Genes · 2022Review
- Mitochondrial transplantation: opportunities and challenges in the treatment of obesity, diabetes, and nonalcoholic fatty liver disease.Journal of translational medicine · 2022Review
- Review
- Germline transmission of donor, maternal and paternal mtDNA in primates.Human reproduction (Oxford, England) · 2021Article
- Mitochondrial DNA Replacement Techniques to Prevent Human Mitochondrial Diseases.International journal of molecular sciences · 2021Review
- Mitochondrial metabolism and DNA methylation: a review of the interaction between two genomes.Clinical epigenetics · 2020Review
- Review
- Inheritance of mitochondrial DNA in humans: implications for rare and common diseases.Journal of internal medicine · 2020Review
- Assessing the fitness consequences of mitonuclear interactions in natural populations.Biological reviews of the Cambridge Philosophical Society · 2019Article
- Cytonuclear integration and co-evolution.Nature reviews. Genetics · 2018Review
- Mitochondrial DNA Heteroplasmy and Purifying Selection in the Mammalian Female Germ Line.Development, growth & differentiation · 2018Review
- Sharpening the cutting edge: additional considerations for the UK debates on embryonic interventions for mitochondrial diseases.Life sciences, society and policy · 2017Article
Corrections and comments
- Comment on
- Erratum issued
Authors and funding
6 authors.
Patrick F ChinneryWellcome Trust Centre for Mitochondrial Research, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom; Institute of Genetic Medicine, Newcastle University, Central Parkway, Newcastle upon Tyne, United Kingdom.
Lyndsey CravenWellcome Trust Centre for Mitochondrial Research, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom.
Shoukhrat MitalipovDivision of Reproductive & Developmental Sciences, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America.
James B StewartMax Planck Institute for Biology of Ageing, Cologne, Germany.
Mary HerbertWellcome Trust Centre for Mitochondrial Research, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom; Newcastle Fertility Centre, International Centre for Life, Newcastle University, Newcastle upon Tyne, United Kingdom.
Douglass M TurnbullWellcome Trust Centre for Mitochondrial Research, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom.
Funding
Histocompatible Primate Embryonic Stem CellsR01HD057121 · NICHD · OREGON HEALTH & SCIENCE UNIVERSITY · PI MITALIPOV, SHOUKHRAT · 2009 to 2013
$3.4MMitochondrial Gene TherapyR01HD063276 · NICHD · OREGON HEALTH & SCIENCE UNIVERSITY · PI MITALIPOV, SHOUKHRAT · 2010 to 2014
$3.0MAltered Nuclear TransferR01HD059946 · NICHD · OREGON HEALTH & SCIENCE UNIVERSITY · PI MITALIPOV, SHOUKHRAT · 2010 to 2014
$2.7MEvaluation of stem cell-derived retinal pigment epithelial cells for retinal diseR01EY021214 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI NEURINGER, MARTHA · 2011 to 2015
$2.1MMedical Research Council G0700718Medical Research Council G0800674Medical Research Council MR/K000608/1NEI NIH HHS R01 EY021214NICHD NIH HHS R01 HD057121NICHD NIH HHS R01 HD059946NICHD NIH HHS R01 HD063276Wellcome Trust 096919Wellcome Trust 101876
Abstract
PubMed holds no abstract for this paper.
Indexed as
AnimalsCholinergic NeuronsHumansLIM-Homeodomain ProteinsProsencephalonSpinal CordTranscription Factorsinsulin gene enhancer binding protein Isl-1LIM-Homeodomain ProteinsTranscription Factors
Identifiers
What OpenQuestion holds
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.