ArticlePLoS computational biology2014
Constraint-based modeling of carbon fixation and the energetics of electron transfer in Geobacter metallireducens.
Article in PLoS computational biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 42 citations in OpenAlex.
- Environmental considerations and bioremediation applications of the metal-, nitrate-, and organohalide-respiring bacteriumApplied and environmental microbiology · 2026Review
- A genome-scale metabolic model for the denitrifying bacterium Thauera sp. MZ1T accurately predicts degradation of pollutants and production of polymers.PLoS computational biology · 2025Article
- Identifying the essential nutritional requirements of the probiotic bacteria Bifidobacterium animalis and Bifidobacterium longum through genome-scale modeling.NPJ systems biology and applications · 2021Article
- Global connectivity in genome-scale metabolic networks revealed by comprehensive FBA-based pathway analysis.BMC microbiology · 2021Article
- Comparative proteomics of Geobacter sulfurreducens PCAEnvironmental microbiology · 2021Article
- Dynamic Allocation of Carbon Storage and Nutrient-Dependent Exudation in a Revised Genome-Scale Model ofFrontiers in genetics · 2021Article
- Modeling of nitrogen fixation and polymer production in the heterotrophic diazotrophMetabolic engineering communications · 2020Article
- Providing new insights on the biphasic lifestyle of the predatory bacterium Bdellovibrio bacteriovorus through genome-scale metabolic modeling.PLoS computational biology · 2020Article
- The hidden chemolithoautotrophic metabolism of Geobacter sulfurreducens uncovered by adaptation to formate.The ISME journal · 2020Article
- Bioelectrochemical systems and synthetic biology: more power, more products.Microbial biotechnology · 2019Article
- Identification of critical connectors in the directed reaction-centric graphs of microbial metabolic networks.BMC bioinformatics · 2019Article
- Spotlight on the Energy Harvest of Electroactive Microorganisms: The Impact of the Applied Anode Potential.Frontiers in microbiology · 2019Article
- Thermodynamic favorability and pathway yield as evolutionary tradeoffs in biosynthetic pathway choice.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- A Genome-Scale Metabolic Model forFrontiers in microbiology · 2018Article
- Construction of aFrontiers in microbiology · 2018Article
- Article
- PSAMM: A Portable System for the Analysis of Metabolic Models.PLoS computational biology · 2016Article
- Integrated In Silico Analysis of Pathway Designs for Synthetic Photo-Electro-Autotrophy.PloS one · 2016Article
- Electrifying microbes for the production of chemicals.Frontiers in microbiology · 2015Review
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Geobacter species are of great interest for environmental and biotechnology applications as they can carry out direct electron transfer to insoluble metals or other microorganisms and have the ability to assimilate inorganic carbon. Here, we report on the capability and key enabling metabolic machinery of Geobacter metallireducens GS-15 to carry out CO2 fixation and direct electron transfer to iron. An updated metabolic reconstruction was generated, growth screens on targeted conditions of interest were performed, and constraint-based analysis was utilized to characterize and evaluate critical pathways and reactions in G. metallireducens. The novel capability of G. metallireducens to grow autotrophically with formate and Fe(III) was predicted and subsequently validated in vivo. Additionally, the energetic cost of transferring electrons to an external electron acceptor was determined through analysis of growth experiments carried out using three different electron acceptors (Fe(III), nitrate, and fumarate) by systematically isolating and examining different parts of the electron transport chain. The updated reconstruction will serve as a knowledgebase for understanding and engineering Geobacter and similar species.
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