ArticlePLoS neglected tropical diseases2014
Model-based investigations of different vector-related intervention strategies to eliminate visceral leishmaniasis on the Indian subcontinent.
Article in PLoS neglected tropical diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Indoor residual spraying for the control of visceral leishmaniasis: A systematic review.PLoS neglected tropical diseases · 2022Pooled it
- Entomological efficacy of durable wall lining with reduced wall surface coverage for strengthening visceral leishmaniasis vector control in Bangladesh, India and Nepal.BMC infectious diseases · 2016Trial
- Endemic and zoonotic cycles of cutaneous leishmaniasis depend on vector feeding preferences: An epidemiological model for Southeastern Mexico.PLoS neglected tropical diseases · 2025Article
- Challenges of using modelling evidence in the visceral leishmaniasis elimination programme in India.PLOS global public health · 2022Article
- Impact of IRS: Four-years of entomological surveillance of the Indian Visceral Leishmaniases elimination programme.PLoS neglected tropical diseases · 2021Article
- Mathematical modelling of the use of insecticide-treated nets for elimination of visceral leishmaniasis in Bihar, India.Royal Society open science · 2021Article
- Probability of false-negative results in microscopical detection of cutaneous leishmaniasis: more accurate screening by kDNA-PCR during epidemiological survey.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2020Article
- Complexity and critical thresholds in the dynamics of visceral leishmaniasis.Royal Society open science · 2020Article
- Visceral leishmaniasis on the Indian Subcontinent: Efficacy of fipronil-based cattle treatment in controlling sand fly populations is dependent on specific aspects of sand fly ecology.PLoS neglected tropical diseases · 2020Article
- Analysis of the IGS rRNA Region and Applicability forJournal of parasitology research · 2020Article
- Visceral leishmaniasis: Spatiotemporal heterogeneity and drivers underlying the hotspots in Muzaffarpur, Bihar, India.PLoS neglected tropical diseases · 2018Article
- The role of case proximity in transmission of visceral leishmaniasis in a highly endemic village in Bangladesh.PLoS neglected tropical diseases · 2018Article
- Policy Recommendations From Transmission Modeling for the Elimination of Visceral Leishmaniasis in the Indian Subcontinent.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Article
- Bionomics of Phlebotomus argentipes in villages in Bihar, India with insights into efficacy of IRS-based control measures.PLoS neglected tropical diseases · 2018Article
- Current Visceral Leishmaniasis Research: A Research Review to Inspire Future Study.BioMed research international · 2018Review
- Adaptation of a malaria surveillance system for use in a visceral leishmaniasis elimination programme.International health · 2017Article
- Elimination of visceral leishmaniasis in the Indian subcontinent: a comparison of predictions from three transmission models.Epidemics · 2017Article
- Challenges in modeling complexity of neglected tropical diseases: a review of dynamics of visceral leishmaniasis in resource limited settings.Emerging themes in epidemiology · 2017Review
- Optimal combinations of control strategies and cost-effective analysis for visceral leishmaniasis disease transmission.PloS one · 2017Article
- Transmission Dynamics of Visceral Leishmaniasis in the Indian Subcontinent - A Systematic Literature Review.PLoS neglected tropical diseases · 2016Review
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The elimination of infectious diseases requires reducing transmission below a certain threshold. The Visceral Leishmaniasis (VL) Elimination Initiative in Southeast Asia aims to reduce the annual VL incidence rate below 1 case per 10,000 inhabitants in endemic areas by 2015 via a combination of case management and vector control. Using a previously developed VL transmission model, we investigated transmission thresholds dependent on measures reducing the sand fly density either by killing sand flies (e.g., indoor residual spraying and long-lasting insecticidal nets) or by destroying breeding sites (e.g., environmental management). Model simulations suggest that elimination of VL is possible if the sand fly density can be reduced by 67% through killing sand flies, or if the number of breeding sites can be reduced by more than 79% through measures of environmental management. These results were compared to data from two recent cluster randomised controlled trials conducted in India, Nepal and Bangladesh showing a 72% reduction in sand fly density after indoor residual spraying, a 44% and 25% reduction through the use of long-lasting insecticidal nets and a 42% reduction after environmental management. Based on model predictions, we identified the parameters within the transmission cycle of VL that predominantly determine the prospects of intervention success. We suggest further research to refine model-based predictions into the elimination of VL.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.