ArticleJournal of perinatology : official journal of the California Perinatal Association2014
Causes of hemolysis in neonates with extreme hyperbilirubinemia.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 85 citations in OpenAlex.
- Addressing the diagnostic gaps in pyruvate kinase deficiency: Consensus recommendations on the diagnosis of pyruvate kinase deficiency.American journal of hematology · 2019Guideline
- Neonatal hereditary spherocytosis: a case report.Italian journal of pediatrics · 2025Article
- Peripheral blood biomarkers as differential diagnostic markers of disease severity in neonates with hyperbilirubinemia.Heliyon · 2025Article
- A Method for Compensating Hemoglobin Interference in Total Serum Bilirubin Measurement Using a Simple Two-Wavelength Reflectance Photometer.Sensors (Basel, Switzerland) · 2024Article
- Associations between COVID-19 and Glucose-6-Phosphate Dehydrogenase Activity in Brazil.The American journal of tropical medicine and hygiene · 2024Article
- Factors associated with neonatal jaundice among neonates admitted at referral hospitals in northeast Ethiopia: a facility-based unmatched case-control study.BMC pregnancy and childbirth · 2024Review
- A "Gold Standard" Test for Diagnosing and Quantifying Hemolysis in Neonates and Infants.Journal of perinatology : official journal of the California Perinatal Association · 2023Review
- A novelExperimental and therapeutic medicine · 2020Article
- Early prediction of adverse outcomes in infants with acute bilirubin encephalopathy.Annals of clinical and translational neurology · 2020Article
- [Pathogenesis and diagnosis of hereditary stomatocytosis].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2020Article
- TcB, FFR, phototherapy and the persistent occurrence of kernicterus spectrum disorder.Journal of perinatology : official journal of the California Perinatal Association · 2020Article
- Rapid Identification of BiallelicMolecular syndromology · 2020Article
- Extreme neonatal hyperbilirubinemia and kernicterus spectrum disorder in Denmark during the years 2000-2015.Journal of perinatology : official journal of the California Perinatal Association · 2020Article
- Noninvasive Detection of Hemolysis with ETCOc Measurement in Neonates at Risk for Significant Hyperbilirubinemia.Neonatology · 2020Article
- Analysis of therapeutic effect of intermittent and continuous phototherapy on neonatal hemolytic jaundice.Experimental and therapeutic medicine · 2019Article
- Novel compound heterozygous mutations in the SPTA1 gene, causing hereditary spherocytosis in a neonate with Coombs‑negative hemolytic jaundice.Molecular medicine reports · 2019Article
- Hereditary stomatocytosis: an unusual cause of severe neonatal jaundice.Singapore medical journal · 2018Article
- ABO hemolytic disease of the fetus and newborn: thirteen years of data after implementing a universal bilirubin screening and management program.Journal of perinatology : official journal of the California Perinatal Association · 2018Article
- Point-of-Care Testing for G6PD Deficiency: Opportunities for Screening.International journal of neonatal screening · 2018Review
- A Supplement to TRANSFUSION Abstract Presentations from the AABB Annual Meeting San Diego, CA, October 7-10, 2017.Transfusion · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe instituted a quality improvement process to enhance our capacity to diagnose genetic hemolytic conditions in neonates with extreme hyperbilirubinemia. STUDY
designDuring a 1-year period, whenever the total serum bilirubin (TSB) was >25 mg dl(-1) a special evaluation was performed. If we deemed an erythrocyte membrane defect likely, based on red blood cell morphology, EMA-flow cytometry was performed. Otherwise 'next-generation' sequencing was performed using a panel of genes involved in neonatal hyperbilirubinemia.
resultTen neonates had a TSB ⩾ 25 mg dl(-1). Two others were evaluated as part of this process at the request of their attending neonatologists, because each had a TSB >14 mg dl(-1) in the first hours after birth and required phototherapy for ⩾ 1 week. Explanations for the jaundice were found in all 12 neonates. Five had hereditary spherocytosis, three of which also had ABO hemolytic disease. Two had pyruvate kinase deficiency. One had severe G6PD deficiency. The other four had ABO hemolytic disease.
conclusionOn the basis of the present small case series, we suggest that among neonates with extreme hyperbilirubinemia, it can be productive to pursue a genetic basis for hemolytic disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.