ReviewNeuropathology and applied neurobiology2014
Review: Hippocampal sclerosis in epilepsy: a neuropathology review.
Review in Neuropathology and applied neurobiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 256 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
256 citing papers in PubMed, 5 syntheses or guidelines pooled it, 552 citations in OpenAlex.
- Ex vivo ultra-high field magnetic resonance imaging of human epileptogenic specimens from primarily the temporal lobe: A systematic review.Neuroradiology · 2025Pooled it
- Mechanisms Underlying Aquaporin-4 Subcellular Mislocalization in Epilepsy.Frontiers in cellular neuroscience · 2022Pooled it
- Neuroanatomical and psychological considerations in temporal lobe epilepsy.Frontiers in neuroanatomy · 2022Pooled it
- Cerebellar Degeneration in Epilepsy: A Systematic Review.International journal of environmental research and public health · 2021Pooled it
- Translating research findings into clinical practice: a systematic and critical review of neuroimaging-based clinical tools for brain disorders.Translational psychiatry · 2020Pooled it
- A dual-modality workflow for quantifying microvascular structure in human temporal lobe epilepsy.IBRO neuroscience reports · 2026Article
- Rapid hippocampal kindling of mice as a model of sudden unexpected death in temporal lobe epilepsy.Experimental neurology · 2026Article
- From metabolic intermediary to neurotransmitter: purinergic signaling in neurophysiology and vulnerability of brain circuits.Bioscience reports · 2026Review
- A potential therapeutic role of unilateral anterior thalamic deep brain stimulation in epileptic spasms: A case report.Epilepsy & behavior reports · 2026Article
- Sigma-1 Expression in Chronic Mouse Models of Temporal Lobe Epilepsy.Molecular neurobiology · 2026Article
- Ten-year cognitive outcomes following epilepsy surgery: Temporal lobectomy versus selective amygdalohippocampectomy.Epilepsia open · 2026Article
- In-depth characterization of the CaScientific reports · 2026Article
- Contrasting effects of PHD finger protein 24 (PHF24) on brain morphology of the spontaneous generalized tonic-clonic seizure model; Noda epileptic rat (NER) and Phf24-null rat.Experimental animals · 2026Article
- Prevalence of epilepsy and seizure history in Finnish neuropathologically examined medico-legal autopsy cases with acute head injuries.BMC research notes · 2026Article
- Hypoxia-inducible factor 1α inhibitor reduces hippocampal neuronal ferroptosis.Neural regeneration research · 2026Article
- Duration-dependent hippocampal structural changes in focal epilepsy: multicenter neuroimaging evidence.Journal of translational medicine · 2026Article
- Apoptosis and Glial Marker Profiles in Hippocampus and Amygdala of Medically Intractable Temporal Lobe Epilepsy.Journal of cellular and molecular medicine · 2026Article
- Dogs with idiopathic epilepsy and focal epileptic seizures lack hilar neuron loss and mossy fiber sprouting of temporal lobe epilepsy.American journal of veterinary research · 2026Article
- Insulin-like growth factor 1 receptor correlates with verbal memory in ILAE type 2 hippocampal sclerosis.Epilepsia · 2026Article
- miRNA-Mediated Regulation of Ferroptosis in Neurological Disorders: Mechanisms and Therapeutic Implications.International journal of molecular sciences · 2026Review
196 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Hippocampal sclerosis (HS) is a common pathology encountered in mesial temporal lobe epilepsy (MTLE) as well as other epilepsy syndromes and in both surgical and post-mortem practice. The 2013 International League Against Epilepsy (ILAE) classification segregates HS into typical (type 1) and atypical (type 2 and 3) groups, based on the histological patterns of subfield neuronal loss and gliosis. In addition, granule cell reorganization and alterations of interneuronal populations, neuropeptide fibre networks and mossy fibre sprouting are distinctive features of HS associated with epilepsies; they can be useful diagnostic aids to discriminate from other causes of HS, as well as highlighting potential mechanisms of hippocampal epileptogenesis. The cause of HS remains elusive and may be multifactorial; the contribution of febrile seizures, genetic susceptibility, inflammatory and neurodevelopmental factors are discussed. Post-mortem based research in HS, as an addition to studies on surgical samples, has the added advantage of enabling the study of the wider network changes associated with HS, the long-term effects of epilepsy on the pathology and associated comorbidities. It is likely that HS is heterogeneous in aspects of its cause, epileptogenetic mechanisms, network alterations and response to medical and surgical treatments. Future neuropathological studies will contribute to better recognition and understanding of these clinical and patho-aetiological subtypes of HS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.