ArticleTissue engineering. Part A2014
Beneficial effects of cerium oxide nanoparticles in development of chondrocyte-seeded hydrogel constructs and cellular response to interleukin insults.
Article in Tissue engineering. Part A, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed.
- Multiscale metal-based nanocomposites for bone and joint disease therapies.Materials today. Bio · 2025Review
- Drug Delivery Strategies and Nanozyme Technologies to Overcome Limitations for Targeting Oxidative Stress in Osteoarthritis.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Cerium Oxide and Chondroitin Sulfate Doped Polyurethane Scaffold to Bridge Tendons.ACS applied materials & interfaces · 2023Article
- Intra-articular nanoparticles based therapies for osteoarthritis and rheumatoid arthritis management.Materials today. Bio · 2023Article
- Nanomedicine and regenerative medicine approaches in osteoarthritis therapy.Aging clinical and experimental research · 2022Review
- Nano Drug Delivery Platforms for Dental Application: Infection Control and TMJ Management-A Review.Polymers · 2021Article
- CeOPolymers · 2021Review
- Size-Dependent Cytotoxicity and Reactive Oxygen Species of Cerium Oxide Nanoparticles in Human Retinal Pigment Epithelia Cells.International journal of nanomedicine · 2021Article
- Current Nanoparticle-Based Technologies for Osteoarthritis Therapy.Nanomaterials (Basel, Switzerland) · 2020Review
- Cerium Oxide Nanoparticles: Recent Advances in Tissue Engineering.Materials (Basel, Switzerland) · 2020Review
- Manganese dioxide nanoparticles protect cartilage from inflammation-induced oxidative stress.Biomaterials · 2019Article
- Morphometry Results of Formed Osteodefects When Using Nanocrystalline CeOInternational journal of dentistry · 2019Article
- Review
- Intra-articular biomaterials-assisted delivery to treat temporomandibular joint disorders.Journal of tissue engineeringArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The harsh inflammatory environment associated with injured and arthritic joints represents a major challenge to articular cartilage repair. In this study, we report the effect of cerium oxide nanoparticles, or nanoceria, in modulating development of engineered cartilage and in combating the deleterious effects of interleukin-1α. Nanoceria was found to be biocompatible with bovine chondrocytes up to a concentration of 1000 μg/mL (60,000 cells/μg of nanoceria), and its presence significantly improved compressive mechanical properties and biochemical composition (i.e., glycosaminoglycans) of engineered cartilage. Raman microspectroscopy revealed that individual chondrocytes with internalized nanoceria have increased concentrations of proline, procollagen, and glycogen as compared with cells without the nanoparticles in their vicinity. The inflammatory response due to physiologically relevant quantities of interluekin-1α (0.5 ng/mL) is partially inhibited by nanoceria. To the best of the authors' knowledge, these results are the first to demonstrate a high potential for nanoceria to improve articular cartilage tissue properties and for their long-term treatment against an inflammatory reaction.
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Registered trials
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