Trial reportThe Journal of clinical endocrinology and metabolism2014
The effect of prepubertal calcium carbonate supplementation on skeletal development in Gambian boys-a 12-year follow-up study.
Trial report in The Journal of clinical endocrinology and metabolism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Pooled it
- Hard facts and misfits: essential ingredients of public health nutrition research.The Proceedings of the Nutrition Society · 2021Pooled it
- Tenth year reenrollment randomized trial investigating the effects of childhood probiotics and calcium supplementation on height and weight at adolescence.Scientific reports · 2021Trial
- Trial
- Trial
- Building better bones in childhood: a randomized controlled study to test the efficacy of a dietary intervention program to increase calcium intake.European journal of clinical nutrition · 2017Trial
- The longitudinal effects of physical activity and dietary calcium on bone mass accrual across stages of pubertal development.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2015Trial
- Association Between Vitamin D Insufficiency and Impaired Bone Density Among Adolescents With Perinatally Acquired HIV Infection.Open forum infectious diseases · 2024Article
- Perspectives on the systematic review for the 2020 Dietary Reference Intakes for Koreans for calcium.Nutrition research and practice · 2022Review
- Anthropometric nutritional status, and social and dietary characteristics of African and Indian adolescents taking part in the TALENT (Transforming Adolescent Lives through Nutrition) qualitative study.Public health nutrition · 2021Article
- Sex differences in requirements for micronutrients across the lifecourse.The Proceedings of the Nutrition Society · 2021Article
- Article
- Four decades of socio-economic inequality and secular change in the physical growth of Guatemalans.Public health nutrition · 2020Article
- Effects of preventive nutrition interventions among adolescents on health and nutritional status in low- and middle-income countries: A systematic review.Campbell systematic reviews · 2020Review
- Higher Longitudinal Milk Intakes Are Associated with Increased Height in a Birth Cohort Followed for 17 Years.The Journal of nutrition · 2018Article
- Cohort Profile: The Kiang West Longitudinal Population Study (KWLPS)-a platform for integrated research and health care provision in rural Gambia.International journal of epidemiology · 2017Article
- Classifying Gestational Weight Gain Trajectories Using the SITAR Growth Model.Paediatric and perinatal epidemiology · 2017Article
- The Gambian Bone and Muscle Ageing Study: Baseline Data from a Prospective Observational African Sub-Saharan Study.Frontiers in endocrinology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
contextCalcium intake during growth is essential for future bone health but varies widely between individuals and populations. The impact on bone of increasing calcium intake is unknown in a population where low calcium intake, stunting, and delayed puberty are common.
objectiveTo determine the effect of prepubertal calcium supplementation on mean age at peak velocity for bone growth and mineral accrual. DESIGN AND
settingProspective follow-up of boys in rural Gambia, West Africa, who had participated in a double-blind, randomized, placebo-controlled trial of calcium supplementation.
participantsEighty boys, initially aged 8.0-11.9 years, were followed up for 12 years.
interventionsSubjects received 1 year of calcium carbonate supplementation (1000 mg daily, 5 d/wk).
main outcome measuresDual-energy x-ray absorptiometry measurements were carried out for whole body (WB), lumbar spine, and total hip bone mineral content, bone area (BA), and WB lean mass. Super imposition by translation and rotation models was made to assess bone growth.
resultsAge at peak velocity was consistently earlier in the calcium group compared to the placebo group, for WB bone mineral content (mean, -6.2 [SE, 3.1]; P = .05), WB BA (mean, -7.0 [SE, 3.2] mo; P = .03), lumbar spine and total hip BA. By young adulthood, supplementation did not change the amount of bone accrued (mineral or size) or the rate of bone growth.
conclusionsTwelve months of prepubertal calcium carbonate supplementation in boys with a low calcium diet advanced the adolescent growth spurt but had no lasting effect on bone mineral or bone size. There is a need for caution when applying international recommendations to different populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.