ArticleBMC public health2014
Follow-up in healthy schoolchildren and in adolescents with Down syndrome: psycho-environmental and genetic determinants of physical activity and its impact on fitness, cardiovascular diseases, inflammatory biomarkers and mental health; the UP&DOWN study.
Article in BMC public health, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 92 citations in OpenAlex.
- Effectiveness of Swimming Program in Adolescents with Down Syndrome.International journal of environmental research and public health · 2021Trial
- Aquatic Exercise as a Complementary Intervention for Cognitive, Behavioral, Motor, and Functional Outcomes in Attention-Deficit/Hyperactivity Disorder, Autism Spectrum Disorder, and Down Syndrome: A Narrative Review.Journal of clinical medicine · 2026Review
- Associations Between Sedentary Behaviors and Sedentary Patterns with Metabolic Syndrome in Children and Adolescents: The UP&DOWN Longitudinal Study.Healthcare (Basel, Switzerland) · 2025Article
- Current insights and prospects for the pathogenesis and treatment of clinical manifestations associated with Down syndrome through neurotransmitter, inflammatory, and oxidative stress pathways.Frontiers in pharmacology · 2025Review
- Article
- Body composition parameters and sarcopenia in adults with Down syndrome: a case-control study.Aging clinical and experimental research · 2024Article
- Effects of exercise, physical activity, and sports on physical fitness in adults with Down syndrome: A systematic review.AIMS public health · 2024Review
- Strength versus aerobic program: effects on body composition and health-related physical fitness levels of youths with Down syndrome.International journal of developmental disabilities · 2024Article
- Longitudinal reallocations of time between 24-h movement behaviours and their associations with inflammation in children and adolescents: the UP&DOWN study.The international journal of behavioral nutrition and physical activity · 2023Article
- Pediatric Population with Down Syndrome: Obesity and the Risk of Cardiovascular Disease and Their Assessment Using Omics Techniques-Review.Biomedicines · 2022Review
- Activity-related typologies and longitudinal change in physical activity and sedentary time in children and adolescents: The UP&DOWN Study.Journal of sport and health science · 2021Article
- Prospective Associations of Physical Activity and Health-Related Physical Fitness in Adolescents with Down Syndrome: The UP&DOWN Longitudinal Study.International journal of environmental research and public health · 2021Article
- The Investigation of Gender Differences in Subjective Wellbeing in Children and Adolescents: The UP&DOWN Study.International journal of environmental research and public health · 2020Article
- Physical Fitness and Self-Rated Health in Children and Adolescents: Cross-Sectional and Longitudinal Study.International journal of environmental research and public health · 2020Article
- Changes in and the mediating role of physical activity in relation to active school transport, fitness and adiposity among Spanish youth: the UP&DOWN longitudinal study.The international journal of behavioral nutrition and physical activity · 2020Article
- Social correlates of sedentary behavior in young people: The UP&DOWN study.Journal of sport and health science · 2020Article
- Independent and combined associations of physical fitness components with inflammatory biomarkers in children and adolescents.Pediatric research · 2018Article
- Neck circumference and clustered cardiovascular risk factors in children and adolescents: cross-sectional study.BMJ open · 2017Article
- Adherence to the Mediterranean diet and academic performance in youth: the UP&DOWN study.European journal of nutrition · 2016Article
- The role of fatness on physical fitness in adolescents with and without Down syndrome: The UP&DOWN study.International journal of obesity (2005) · 2016Article
Corrections and comments
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Authors and funding
14 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAn objective diagnosis of sedentary behaviour as well as of the physical activity and fitness levels in youth and to better understand how lifestyle is associated with cardiovascular disease risk factors and other phenotypes is of clinical and public health interest, and might be informative for developing intervention studies focused on the promotion of physical activity in these population. The aim of this methodological paper is to describe the design and assessment in the UP&DOWN study. METHODS/
designThe UP&DOWN study is a multi-center follow-up design where 2225 Spanish primary and secondary schoolchildren from Cadiz and Madrid, respectively, as well as 110 Spanish adolescents with Down syndrome from Madrid and Toledo were recruited to be assessed. Nine main measurement categories are assessed: i) socio-demographic and early determinants; ii) environmental determinants; iii) physical activity and sedentary behaviour; iv) health-related fitness; v) blood pressure and resting heart rate; vi) mental health; vii) dietary patterns; viii) blood samples; and ix) genetic analysis. During the 3-yr follow-up study, socio-demographic and early determinants, and genetic analysis are only assessed in the first year. Blood sampling is assessed in the first year and the third year (2nd follow-up), and all the other measurements are assessed every year. DISCUSSION: The findings of the UP&DOWN study may help the Health Information Systems and policy makers to identify the target population for primary prevention and health promotion policies, and to develop and test preventive strategies. Moreover, these data will allow following the trends at population level, as well as to modify/adapt/create new evidence-based physical activity guidelines at national level. The findings will also serve as a scientific platform for interventional studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.