ArticleInternational journal of experimental pathology2014
Duration of injury correlates with necrosis in caerulein-induced experimental acute pancreatitis: implications for pathophysiology.
Article in International journal of experimental pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Optogenetic stimulation of the brainstem dorsal motor nucleus ameliorates acute pancreatitis.Frontiers in immunology · 2023Article
- Effect of calorie-restriction and rapamycin on autophagy and the severity of caerulein-induced experimental acute pancreatitis in mice.Frontiers in gastroenterology (Lausanne, Switzerland) · 2022Article
- Lure-and-kill macrophage nanoparticles alleviate the severity of experimental acute pancreatitis.Nature communications · 2021Article
- Long Non-coding RNA FENDRR Modulates Autophagy Through Epigenetic Suppression of ATG7 via Binding PRC2 in Acute Pancreatitis.Inflammation · 2021Article
- Pancreatic gene expression during recovery after pancreatitis reveals unique transcriptome profiles.Scientific reports · 2018Article
- IRF5 regulates lung macrophages M2 polarization during severe acute pancreatitisWorld journal of gastroenterology · 2016Article
- Spautin-1 Ameliorates Acute Pancreatitis via Inhibiting Impaired Autophagy and Alleviating Calcium Overload.Molecular medicine (Cambridge, Mass.) · 2016Article
- Changes in gene expression of tumor necrosis factor alpha and interleukin 6 in a canine model of caerulein-induced pancreatitis.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2016Article
- Functional role of MicroRNA-19b in acinar cell necrosis in acute necrotizing pancreatitis.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2016Article
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Authors and funding
5 authors at 1 institution in 1 country.
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Abstract
Pancreatic acinar cell necrosis is indicative of severe pancreatitis and the degree of necrosis is an index of its outcome. We studied whether the dose and duration of injury correlates with severity, particularly in terms of necrosis, in caerulein-induced acute pancreatitis (AP) in Swiss albino mice. In addition to control group 1 (G1), groups 2 and 3 received four injections of caerulein every hour but were sacrificed at five hours (G2) and nine hours (G3) respectively, and group 4 received eight injections and was sacrificed at nine hours (G4). The severity of pancreatitis was assessed histopathologically and biochemically. The histopathological scores of pancreatitis in groups 3 and 4 were significantly higher than in groups 1 and 2 (4 vs. 1, 4 vs. 2, 3 vs. 1, 3 vs. 2; P < 0.05). TUNEL-positive apoptotic cells were significantly higher in groups 2 and 3 compared with groups 1 and 4 (P < 0.05). Necrosis was significantly more in group 4 than other groups (37.49% (4.68) vs. 19.97% (1.60) in G2; 20.36% (1.56) in G3; P = 0.006 for G 2 vs. 4 and P = 0.019 for G 3 vs. 4). Electron microscopy revealed numerous autophagosomes in groups 2 and 3 and mitochondrial damage and necrosis in group 4. The pancreatic and pulmonary myeloperoxidase activity in group 4 was significantly higher than that in the other groups (P < 0.01). Hence, severity of pancreatitis is a function of the dose of injurious agent, while inflammation is both dose and duration dependent, which may also explain the wide spectrum of severity of AP seen in clinical practice.
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