ArticleInfluenza and other respiratory viruses2014
Comparative epidemiology of human metapneumovirus- and respiratory syncytial virus-associated hospitalizations in Guatemala.
Article in Influenza and other respiratory viruses, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Clinical manifestations of respiratory syncytial virus infection and the risk of wheezing and recurrent wheezing illness: a systematic review and meta-analysis.World journal of pediatrics : WJP · 2023Pooled it
- Human metapneumovirus in patients hospitalized with acute respiratory infections: A meta-analysis.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2016Pooled it
- Pediatric burden and seasonality of human metapneumovirus over 5 years in Managua, Nicaragua.Influenza and other respiratory viruses · 2022Article
- Epidemiology of viral respiratory infections in a pediatric reference hospital in Central Panama.BMC infectious diseases · 2021Article
- Risk factors for hospitalized respiratory syncytial virus disease and its severe outcomes.Influenza and other respiratory viruses · 2020Article
- Clinical Characteristics of Hospitalized Infants With Laboratory-Confirmed Pertussis in Guatemala.Journal of the Pediatric Infectious Diseases Society · 2018Article
- Article
- The Burden of Human Metapneumovirus and Respiratory Syncytial Virus Infections in Hospitalized Norwegian Children.The Journal of infectious diseases · 2017Article
- Human metapnuemovirus infections in hospitalized children and comparison with other respiratory viruses. 2005-2014 prospective study.PloS one · 2017Article
- Etiology of severe pneumonia in Ecuadorian children.PloS one · 2017Observational
- Detection of Human Metapneumovirus and Respiratory Syncytial Virus by Real-Time Polymerase Chain Reaction Among Hospitalized Young Children in Iran.Jundishapur journal of microbiology · 2016Article
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Abstract
backgroundHuman metapneumovirus (HMPV) is an important cause of acute respiratory infections (ARI), but little is known about how it compares with respiratory syncytial virus (RSV) in Central America.
objectivesIn this study, we describe hospitalized cases of HMPV- and RSV-ARI in Guatemala.
methodsWe conducted surveillance at three hospitals (November 2007-December 2012) and tested nasopharyngeal and oropharyngeal swab specimens for HMPV and RSV using real-time reverse transcription-polymerase chain reaction. We calculated incidence rates, and compared the epidemiology and outcomes of HMPV-positive versus RSV-positive and RSV-HMPV-negative cases.
resultsWe enrolled and tested specimens from 6288 ARI cases; 596 (9%) were HMPV-positive and 1485 (24%) were RSV-positive. We observed a seasonal pattern of RSV but not HMPV. The proportion HMPV-positive was low (3%) and RSV-positive high (41%) for age <1 month, whereas these proportions were similar (~20%) by age 2 years. The annual incidence of hospitalized HMPV-ARI was 102/100 000 children aged <5 years [95% confidence interval (CI): 75-178], 2.6/100 000 persons aged 5-17 years (95%CI: 1.2-5.0), and 2.6/100 000 persons aged ≥ 18 years (95%CI: 1.5-4.9). Among children aged <5 years, HMPV-positive cases were less severe than HMPV-RSV-negative cases after adjustment for confounders [odds ratio (OR) for intensive care = 0.63, 95% CI 0.47-0.84]; OR for death = 0.46, 95% CI 0.23-0.92).
conclusionsHuman metapneumovirus is a substantial contributor to ARI hospitalization in Guatemala, but HMPV hospitalizations are less frequent than RSV and, in young children, less severe than other etiologies. Preventive interventions should take into account the wide variation in incidence by age and unpredictable timing of incidence peaks.
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