Evidence map›Paper›PMID 24761305›Full record

ArticleBiomedical optics express2014

Reduced interhemispheric functional connectivity of children with autism spectrum disorder: evidence from functional near infrared spectroscopy studies.

Huilin Zhu, Yuebo Fan, Huan Guo, Dan Huang, Sailing He

Abstract read
In one paragraph

Article in Biomedical optics express, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Trial
  2. Article
  3. Linking Connectivity Dynamics to Symptom Severity and Cognitive Abilities in Children with Autism Spectrum Disorder: An FNIRS Study.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Looking Back at the Next 40 Years of ASD Neuroscience Research.Journal of autism and developmental disorders · 2021
    Review
  15. Article
  16. Regional Haemodynamic and Metabolic Coupling in Infants.Frontiers in human neuroscience · 2021
    Article
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Huilin ZhuCentre for Optical and Electromagnetic Research, ZJU-SCNU Joint Research Center of Photonics, South China Normal University (SCNU), Guangzhou, 510006, China ; School of Psychology, South China Normal University (SCNU)), Guangzhou 510631, China.
Yuebo FanGuangzhou Rehabilitation and Research Center for Children with ASD, Guangzhou, 510540, China.
Huan GuoSchool of Psychology, South China Normal University (SCNU)), Guangzhou 510631, China.
Dan HuangGuangzhou Rehabilitation and Research Center for Children with ASD, Guangzhou, 510540, China.
Sailing HeCentre for Optical and Electromagnetic Research, ZJU-SCNU Joint Research Center of Photonics, South China Normal University (SCNU), Guangzhou, 510006, China ; JORCEP, Department of Electromagnetic Engineering, School of Electrical Engineering, Royal Institute of Technology, Stockholm, 10044, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autism spectrum disorder (ASD) is a neuro-developmental disorder, which has been associated with atypical neural synchronization. In this study, functional near infrared spectroscopy (fNIRS) was used to study the differences in functional connectivity in bilateral inferior frontal cortices (IFC) and bilateral temporal cortices (TC) between ASD and typically developing (TD) children between 8 and 11 years of age. As the first report of fNIRS study on the resting state functional connectivity (RSFC) in children with ASD, ten children with ASD and ten TD children were recruited in this study for 8 minute resting state measurement. Compared to TD children, children with ASD showed reduced interhemispheric connectivity in TC. Children with ASD also showed significantly lower local connectivity in bilateral temporal cortices. In contrast to TD children, children with ASD did not show typical patterns of symmetry in functional connectivity in temporal cortex. These results support the feasibility of using the fNIRS method to assess atypical functional connectivity of cortical responses of ASD and its potential application in diagnosis.

Indexed as

(170.2655) Functional monitoring and imaging(170.3880) Medical and biological imaging(170.5380) Physiology

Identifiers

PMID24761305
PMCPMC3985986

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.