ArticleBiomedical optics express2014
Optical stimulation enables paced electrophysiological studies in embryonic hearts.
Article in Biomedical optics express, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04601337 (Clinical Safety and Efficacy of Infrared Neural Stimulation During Nerve Transfers), which is not on this map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical Safety and Efficacy of Infrared Neural Stimulation During Nerve Transfers
Who cites it
14 citing papers in PubMed.
- Prenatal ethanol exposure impairs the conduction delay at the atrioventricular junction in the looping heart.American journal of physiology. Heart and circulatory physiology · 2021Article
- Fiberoptic array for multiple channel infrared neural stimulation of the brain.Neurophotonics · 2021Article
- Optical Electrophysiology in the Developing Heart.Journal of cardiovascular development and disease · 2018Review
- A review of optical pacing with infrared light.Journal of neural engineering · 2018Review
- Increased regurgitant flow causes endocardial cushion defects in an avian embryonic model of congenital heart disease.Congenital heart disease · 2017Article
- An infrared optical pacing system for screening cardiac electrophysiology in human cardiomyocytes.PloS one · 2017Article
- Volumetric optical mapping in early embryonic hearts using light-sheet microscopy.Biomedical optics express · 2016Article
- Infrared inhibition of embryonic hearts.Journal of biomedical optics · 2016Article
- Probing the Electrophysiology of the Developing Heart.Journal of cardiovascular development and disease · 2016Review
- Mapping conduction velocity of early embryonic hearts with a robust fitting algorithm.Biomedical optics express · 2015Article
- Connecting teratogen-induced congenital heart defects to neural crest cells and their effect on cardiac function.Birth defects research. Part C, Embryo today : reviews · 2014Review
- Optical Stimulation of Neurons.Current molecular imaging · 2014Article
- Three-dimensional correction of conduction velocity in the embryonic heart using integrated optical mapping and optical coherence tomography.Journal of biomedical optics · 2014Article
- Capturing structure and function in an embryonic heart with biophotonic tools.Frontiers in physiology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Cardiac electrophysiology plays a critical role in the development and function of the heart. Studies of early embryonic electrical activity have lacked a viable point stimulation technique to pace in vitro samples. Here, optical pacing by high-precision infrared stimulation is used to pace excised embryonic hearts, allowing electrophysiological parameters to be quantified during pacing at varying rates with optical mapping. Combined optical pacing and optical mapping enables electrophysiological studies in embryos under more physiological conditions and at varying heart rates, allowing detection of abnormal conduction and comparisons between normal and pathological electrical activity during development in various models.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.