Evidence map›Paper›PMID 24761279›Full record

ReviewJournal of caffeine research2013

Caffeine Use Disorder: A Comprehensive Review and Research Agenda.

Steven E Meredith, Laura M Juliano, John R Hughes, Roland R Griffiths

2 registry-linked trialsAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of caffeine research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 64 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 4 pooled it
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05170113 nacompletednot on this mapstarted 2021, after this paper: background citation

A Pilot, Randomized, Double-blind, Placebo-controlled, Parallel Design Study to Evaluate the Effectiveness and Safety of an Alpinia Galanga Formulation, Theacrine Formulation, and Caffeine Formulation on Fatigue, Mental Acuity, and Cognitive Health Among Overall Healthy Participants

TypeinterventionalSponsorSupplement Formulators, Inc.Ran2021 to 2022Enrolled79ConditionsFatigueArmsAlpinia galanga formulation, Theacrine formulation, Caffeine formulation, Placebo
NCT06841666 early_phase1not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Evaluating the Efficacy of Atomoxetine in Reducing Primary Nocturnal Enuresis in Children With ADHD

TypeinterventionalSponsorTanta UniversityRan2025 to 2025Enrolled100ConditionsADHD, Primary Nocturnal EnuresisArmsAtomoxetine, Placebo
3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 4 syntheses or guidelines pooled it, 199 citations in OpenAlex.

  1. Pooled it
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  13. Caffeine in Aging Brains: Cognitive Enhancement, Neurodegeneration, and Emerging Concerns About Addiction.International journal of environmental research and public health · 2025
    Review
  14. Article
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4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Steven E MeredithDepartment of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine , Baltimore, Maryland.
Laura M JulianoDepartment of Psychology, American University , Washington, District of Columbia.
John R HughesDepartment of Psychology, University of Vermont , Burlington, Vermont. ; Department of Psychiatry, University of Vermont , Burlington, Vermont.
Roland R GriffithsDepartment of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine , Baltimore, Maryland. ; Department of Neuroscience, The Johns Hopkins University School of Medicine , Baltimore, Maryland.
Johns Hopkins University · USAmerican University · USUniversity of Vermont · US

Funding

HUMAN BEHAVIORAL PHARMACOLOGY OF SUBSTANCE ABUSET32DA007209 · NIDA · JOHNS HOPKINS UNIVERSITY · PI Eric C. Strain, Elise M Weerts · 1985 to 2026
$12.9M
LICIT &ILLICIT ABUSED STIMULANT DRUGSR01DA003890 · NIDA · JOHNS HOPKINS UNIVERSITY · PI LEE, DUSTIN CLARK · 1985 to 2021
$8.0M
NIDA NIH HHS R01 DA003890NIDA NIH HHS T32 DA007209
6 · The paper itself

Abstract

Caffeine is the most commonly used drug in the world. Although consumption of low to moderate doses of caffeine is generally safe, an increasing number of clinical studies are showing that some caffeine users become dependent on the drug and are unable to reduce consumption despite knowledge of recurrent health problems associated with continued use. Thus, the World Health Organization and some health care professionals recognize caffeine dependence as a clinical disorder. In this comprehensive literature review, we summarize published research on the biological evidence for caffeine dependence; we provide a systematic review of the prevalence of caffeine dependence and rates of endorsement of clinically meaningful indicators of distress and functional impairment among habitual caffeine users; we discuss the diagnostic criteria for Caffeine Use Disorder-a condition for further study included in the

Identifiers

PMID24761279
PMCPMC3777290
OpenAlexW1997958721

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.