ArticleAnnals of medical and health sciences research2014
The Relaxant Effect of Seed's Essential Oil and Oleo-Gum-Resin of Ferula Assa-Foetida on Isolated Rat's Ileum.
Article in Annals of medical and health sciences research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 45 citations in OpenAlex.
- Effects of Limb Remote Ischemic Conditioning and Asafoetida on Biochemical, Histological, and Neurological Parameters and Metabolic Gene Expression in Diabetic Rats.Combinatorial chemistry & high throughput screening · 2026Article
- A Comprehensive Review of the Anticancer Activity of Farnesiferol C and Umbelliferone.Anti-cancer agents in medicinal chemistry · 2026Review
- Osteo-inductive potential of homoeopathy potencies of Asafoetida on multipotent mesenchymal stem cells in vitro.3 Biotech · 2025Article
- Antiviral Effect ofCurrent pharmaceutical biotechnology · 2025Review
- A Review of Anticancer Activity ofCurrent pharmaceutical design · 2025Review
- A Comprehensive Review of the Pharmacological Effects of Genus Ferula on Central Nervous System Disorders.Central nervous system agents in medicinal chemistry · 2024Review
- Review of potential spermatogenic and aphrodisiac effects of the Ferula genus.Clinical and experimental reproductive medicine · 2023Article
- Anticancer potential ofWorld journal of biological chemistry · 2023Review
- Metabolic Profile, Bioactivities, and Variations in the Chemical Constituents of Essential Oils of theFrontiers in pharmacology · 2020Review
- The Possible Therapeutic Effects of Some Medicinal Plants for Chronic Cough in Children.Evidence-based complementary and alternative medicine : eCAM · 2020Review
- Preventive Effect ofInternational journal of preventive medicine · 2020Article
- Sub-acute and acute toxicity of Ferula asafoetida and Silybum marianum formulation and effect of the formulation on delaying gastric emptying.BMC complementary and alternative medicine · 2019Article
- Biological activities and medicinal properties of Asafoetida: A review.Journal of traditional and complementary medicine · 2017Review
- The effect of PhytopajAvicenna journal of phytomedicineArticle
- Evaluation of Cytotoxicity Effects of Oleo-Gum-Resin and Its Essential Oil ofIndian journal of medical and paediatric oncology : official journal of Indian Society of Medical & Paediatric OncologyArticle
- Antitumor effect of Ferula assa foetida oleo gum resin against breast cancer induced by 4T1 cells in BALB/c mice.Journal of Ayurveda and integrative medicineArticle
- Evaluation of Toxicity Effects of Asafetida on Biochemical, Hematological, and Histological Parameters in Male Wistar Rats.Toxicology internationalArticle
- Effect ofIndian journal of nephrologyArticle
- Role of the potassium channels in vasorelaxant effect of asafoetida essential oil.Avicenna journal of phytomedicineArticle
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn Iranian folk medicine, several plants are used for treatment of gastrointestinal disorders, such as diarrhea and spasm. One of these herbal medications are the essential oil yielded from seeds of Ferula assa-foetida L. and an oleo-gum-resin known as asafetida, which is exudated from its root. F. assa-foetida grows wildly in south and central mountains of Iran.
aimIn this study, relaxant effect of asafoetida and seed's essential oil of F. assa-foetida was investigated in isolated rat's ileum in three doses. MATERIALS AND
methodsA total of 5 cm of ileum was removed and sets for recording its isotonic contractions. The amplitude of contractions induced by different doses of asafoetida and essential oil before and after exposing the specimens with cumulative logarithmic concentrations of acetylcholine (Ach) was evaluated. The relaxant effect of asafoetida and seed's essential oil of F. assa-foetida was investigated in isolated rat's ileum in three doses (0.1 0.2 and 0.3%). All statistical analysis was by GraphPad Prism 5 (San Diego, California) and comparisons were made by means of the analysis of variances followed by Tukey's test. The statistical significance was considered as P < 0.05.
resultsAsafoetida produced an antispasmodic effect on Ach induced contraction in 0.2% and 0.3% concentrations. Our findings also showed that essential oil has significant antispasmodic action against cumulative concentrations of 10(-12) up to 10(-2) M Ach. In spasmolytic evaluation, our findings showed that the essential oil derived from F. assa-foetida seed in concentrations of 0.2% and 0.3% significantly reduced Ach (10(-4) M) induced contractions. Exposure to the 0.2% and 0.3% asafoetida, reduced the percentage of maximum contraction induced by 10(-4) M Ach to 43% and 12% respectively, which this reduction was statistically significant.
conclusionThe results of the present study, supports the traditional claim of asafoetida as an antispasmodic therapeutic.
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