ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2014
Mercaptoacetate and fatty acids exert direct and antagonistic effects on nodose neurons via GPR40 fatty acid receptors.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- The critical role of gut-brain signalling in eating behaviour and obesity.Nature reviews. Gastroenterology & hepatology · 2026Review
- Mechanistic insights into the liver-brain axis during chronic liver disease.Nature reviews. Gastroenterology & hepatology · 2026Review
- Gut sensing of food ingredients and interoception-mediated regulation of feeding and glucose metabolism.Physiological reports · 2025Review
- Vagal Sensory Gut-Brain Pathways That Control Eating-Satiety and Beyond.Comprehensive physiology · 2025Review
- Hepatic interoception in health and disease.Autonomic neuroscience : basic & clinical · 2024Review
- Lesion of NPY Receptor-expressing Neurons in Perifornical Lateral Hypothalamus Attenuates Glucoprivic Feeding.Endocrinology · 2024Article
- The physiological control of eating: signals, neurons, and networks.Physiological reviews · 2022 · on this mapArticle
- Intact vagal gut-brain signalling prevents hyperphagia and excessive weight gain in response to high-fat high-sugar diet.Acta physiologica (Oxford, England) · 2021Article
- Omega 3 fatty acids stimulate thermogenesis during torpor in the Arctic Ground Squirrel.Scientific reports · 2021Article
- Blunted Vagal Cocaine- and Amphetamine-Regulated Transcript Promotes Hyperphagia and Weight Gain.Cell reports · 2020Article
- Palmitic Acid Reduces the Autophagic Flux and Insulin Sensitivity Through the Activation of the Free Fatty Acid Receptor 1 (FFAR1) in the Hypothalamic Neuronal Cell Line N43/5.Frontiers in endocrinology · 2019Article
- The vagus neurometabolic interface and clinical disease.International journal of obesity (2005) · 2018Review
- Signalling from the periphery to the brain that regulates energy homeostasis.Nature reviews. Neuroscience · 2018Review
- Palmitic Acid-BSA enhances Amyloid-β production through GPR40-mediated dual pathways in neuronal cells: Involvement of the Akt/mTOR/HIF-1α and Akt/NF-κB pathways.Scientific reports · 2017Article
- Novel developments in vagal afferent nutrient sensing and its role in energy homeostasis.Current opinion in pharmacology · 2016Review
- Bugs, guts and brains, and the regulation of food intake and body weight.International journal of obesity supplements · 2016Review
- Deletion of GPR40 fatty acid receptor gene in mice blocks mercaptoacetate-induced feeding.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Article
- Mercaptoacetate blocks fatty acid-induced GLP-1 secretion in male rats by directly antagonizing GPR40 fatty acid receptors.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Article
- Hindbrain Catecholamine Neurons Activate Orexin Neurons During Systemic Glucoprivation in Male Rats.Endocrinology · 2015Article
- Enhancing hepatic mitochondrial fatty acid oxidation stimulates eating in food-deprived mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
β-mercaptoacetate (MA) is a drug known to block mitochondrial oxidation of medium- and long-chain fatty acids (FAs) and to stimulate feeding. Because MA-induced feeding is vagally dependent, it has been assumed that the feeding response is mediated by MA's antimetabolic action at a peripheral, vagally innervated site. However, MA's site of action has not yet been identified. Therefore, we used fluorescent calcium measurements in isolated neurons from rat nodose ganglia to determine whether MA has direct effects on vagal sensory neurons. We found that MA alone did not alter cytosolic calcium concentrations in nodose neurons. However, MA (60 μM to 6 mM) significantly decreased calcium responses to both linoleic acid (LA; 10 μM) and caprylic acid (C8; 10 μM) in all neurons responsive to LA and C8. GW9508 (40 μM), an agonist of the FA receptor, G protein-coupled receptor 40 (GPR40), also increased calcium levels almost exclusively in FA-responsive neurons. MA significantly inhibited this response to GW9508. MA did not inhibit calcium responses to serotonin, high K(+), or capsaicin, which do not utilize GPRs, or to CCK, which acts on a different GPR. GPR40 was detected in nodose ganglia by RT-PCR. Results suggest that FAs directly activate vagal sensory neurons via GPR40 and that MA antagonizes this effect. Thus, we propose that MA's nonmetabolic actions on GPR40 membrane receptors, expressed by multiple peripheral tissues in addition to the vagus nerve, may contribute to or mediate MA-induced stimulation of feeding.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.