Evidence map›Paper›PMID 24760873›Full record

SynthesisInternational journal of epidemiology2014

Preventing the onset of major depressive disorder: a meta-analytic review of psychological interventions.

Kim van Zoonen, Claudia Buntrock, David Daniel Ebert, Filip Smit, Charles F Reynolds, Aartjan T F Beekman, Pim Cuijpers

Registry-linked trialAbstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in International journal of epidemiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05633186 (Sustainable Upscaling of Depression Prevention, Finding the Optimal Balance Between Investment and Benefit), which is not on this map. Cited by 174 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
174citing papers in PubMed, 11 pooled it
48.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05633186 nacompletednot on this mapstarted 2022, after this paper: background citation

Sustainable Upscaling of Depression Prevention, Finding the Optimal Balance Between Investment and Benefit (SPRINT)

TypeinterventionalSponsorVU University of AmsterdamRan2022 to 2023Enrolled307ConditionsDepressionArmsMoodbuster Life, Mobile application, Guidance by a coach, Motivational Content
3 · Its place in the literature

Who cites it

174 citing papers in PubMed, 11 syntheses or guidelines pooled it, 430 citations in OpenAlex.

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114 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Kim van ZoonenDepartment of Clinical Psychology and EMGO Institute for Health and Care Research, VU University, Amsterdam, The Netherlands, Leuphana University Innovation Incubator, Division Health Trainings Online, Lüneburg, Germany, Philips University, Department of Psychology, Clinical Psychology and Psychotherapy, Marburg, Germany, Trimbos Institute (Netherlands Institute of Mental Health and Addiction), Utrecht, The Netherlands, Department of Epidemiology and Biostastics, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA and Department of Psychiatry and EMGO Institute for Health and Care Research, VU University, Amsterdam, The Netherlands.
Claudia Buntrock
David Daniel Ebert
Filip Smit
Charles F Reynolds
Aartjan T F Beekman
Pim Cuijpers
University of Pittsburgh · US

Funding

University of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8M
RESEARCH METHODS COREP30MH090333 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REYNOLDS, CHARLES F · 2011 to 2015
$8.3M
NCATS NIH HHS UL1 TR000005NIMH NIH HHS P30 MH090333NIMH NIH HHS P30MH90333
6 · The paper itself

Abstract

backgroundDepressive disorders are highly prevalent, have a detrimental impact on the quality of life of patients and their relatives and are associated with increased mortality rates, high levels of service use and substantial economic costs. Current treatments are estimated to only reduce about one-third of the disease burden of depressive disorders. Prevention may be an alternative strategy to further reduce the disease burden of depression.

methodsWe conducted a meta-analysis of randomized controlled trials examining the effects of preventive interventions in participants with no diagnosed depression at baseline on the incidence of diagnosed depressive disorders at follow-up. We identified 32 studies that met our inclusion criteria.

resultsWe found that the relative risk of developing a depressive disorder was incidence rate ratio = 0.79 (95% confidence interval: 0.69-0.91), indicating a 21% decrease in incidence in prevention groups in comparison with control groups. Heterogeneity was low (I(2) = 24%). The number needed to treat (NNT) to prevent one new case of depressive disorder was 20. Sensitivity analyses revealed no differences between type of prevention (e.g. selective, indicated or universal) nor between type of intervention (e.g. cognitive behavioural therapy, interpersonal psychotherapy or other). However, data on NNT did show differences.

conclusionsPrevention of depression seems feasible and may, in addition to treatment, be an effective way to delay or prevent the onset of depressive disorders. Preventing or delaying these disorders may contribute to the further reduction of the disease burden and the economic costs associated with depressive disorders.

Indexed as

AdolescentAdultAgedFemaleGlobal HealthHumansIncidenceMajor Depressive DisorderMaleMiddle AgedPsychotherapyRandomized Controlled Trials as TopicRisk FactorsYoung AdultdepressionPreventionRCT

Identifiers

PMID24760873
PMCPMC4023317
OpenAlexW2121778399

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.