ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Vasoactive intestinal polypeptide mediates circadian rhythms in mammalian olfactory bulb and olfaction.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 52 citations in OpenAlex.
- Motor Cortex VIP Interneurons Participate in Dexmedetomidine-Associated Sleep Modulation.Molecular neurobiology · 2026Article
- Time of day alters olfactory bulb immune state with ramifications for intranasal inflammatory challenge.Cell reports · 2026Article
- Brain circadian clocks timing the 24h rhythms of behavior.Npj biological timing and sleep · 2025Review
- Gene expression differences in the olfactory bulb associated with differential social interactions and olfactory deficits in Pax6 heterozygous mice.Biology open · 2025Article
- Daily glucocorticoids promote glioblastoma growth and circadian synchrony to the host.Cancer cell · 2025Article
- Daily glucocorticoids promote glioblastoma growth and circadian synchrony to the host.bioRxiv : the preprint server for biology · 2024Article
- Circadian neurogenetics and its implications in neurophysiology, behavior, and chronomedicine.Neuroscience and biobehavioral reviews · 2024Review
- The circadian clock in the piriform cortex intrinsically tunes daily changes of odor-evoked neural activity.Communications biology · 2023Article
- Potential neural substrates underlying circadian and olfactory disruptions in preclinical Alzheimer's disease.Frontiers in neuroscience · 2023Review
- Article
- Circadian clock synchrony and chronotherapy opportunities in cancer treatment.Seminars in cell & developmental biology · 2022Review
- Cell-Type-Specific Circadian Bioluminescence Rhythms inJournal of biological rhythms · 2022Article
- Impacts of vitamin A deficiency on biological rhythms: Insights from the literature.Frontiers in nutrition · 2022Review
- Time-of-day as a critical biological variable.Neuroscience and biobehavioral reviews · 2021Review
- Article
- Extrinsic neuromodulation in the rodent olfactory bulb.Cell and tissue research · 2021Review
- Reduced VIP Expression Affects Circadian Clock Function in VIP-IRES-CRE Mice (JAX 010908).Journal of biological rhythms · 2020Article
- Illuminating and Sniffing Out the Neuromodulatory Roles of Dopamine in the Retina and Olfactory Bulb.Frontiers in cellular neuroscience · 2020Review
- Keeping time in the lamina terminalis: Novel oscillator properties of forebrain sensory circumventricular organs.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Circadian regulation of membrane physiology in neural oscillators throughout the brain.The European journal of neuroscience · 2020Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Accumulating evidence suggests that the olfactory bulbs (OBs) function as an independent circadian system regulating daily rhythms in olfactory performance. However, the cells and signals in the olfactory system that generate and coordinate these circadian rhythms are unknown. Using real-time imaging of gene expression, we found that the isolated olfactory epithelium and OB, but not the piriform cortex, express similar, sustained circadian rhythms in PERIOD2 (PER2). In vivo, PER2 expression in the OB of mice is circadian, approximately doubling with a peak around subjective dusk. Furthermore, mice exhibit circadian rhythms in odor detection performance with a peak at approximately subjective dusk. We also found that circadian rhythms in gene expression and odor detection performance require vasoactive intestinal polypeptide (VIP) or its receptor VPAC2R. VIP is expressed, in a circadian manner, in interneurons in the external plexiform and periglomerular layers, whereas VPAC2R is expressed in mitral and external tufted cells in the OB. Together, these results indicate that VIP signaling modulates the output from the OB to maintain circadian rhythms in the mammalian olfactory system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.