ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Source-reconstruction of event-related fields reveals hyperfunction and hypofunction of cortical circuits in antipsychotic-naive, first-episode schizophrenia patients during Mooney face processing.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 54 citations in OpenAlex.
- Face pareidolia is enhanced by 40 Hz transcranial alternating current stimulation (tACS) of the face perception network.Scientific reports · 2023Trial
- Ketamine Dysregulates the Amplitude and Connectivity of High-Frequency Oscillations in Cortical-Subcortical Networks in Humans: Evidence From Resting-State Magnetoencephalography-Recordings.Schizophrenia bulletin · 2015Trial
- Psychosis Risk is Associated with Increased Multimodal Reports of Socially Salient Content in Degraded Stimuli.Schizophrenia bulletin open · 2026Article
- Article
- The Neural Correlates of Developmental Prosopagnosia: Twenty-Five Years on.Brain sciences · 2023Review
- Deep learning applied to EEG source-data reveals both ventral and dorsal visual stream involvement in holistic processing of social stimuli.Scientific reports · 2023Article
- Wider and Stronger Inhibitory Ring of the Attentional Focus in Schizophrenia.Brain sciences · 2023Article
- Perceptual Functioning.Current topics in behavioral neurosciences · 2023Article
- A neural model of modified excitation/inhibition and feedback levels in schizophrenia.Frontiers in psychiatry · 2023Article
- Genetic risk for schizophrenia is associated with altered visually-induced gamma band activity: evidence from a population sample stratified polygenic risk.Translational psychiatry · 2021Article
- Computerized Assessment of Psychosis Risk.Journal of psychiatry and brain science · 2021Article
- Theta- and Gamma-Band Activity Discriminates Face, Body and Object Perception.Frontiers in human neuroscience · 2020Article
- Neurophysiological Face Processing Deficits in Patients With Chronic Schizophrenia: An MEG Study.Frontiers in psychiatry · 2020Article
- A MEG Study of Visual Repetition Priming in Schizophrenia: Evidence for Impaired High-Frequency Oscillations and Event-Related Fields in Thalamo-Occipital Cortices.Frontiers in psychiatry · 2020Article
- Neutral face and complex object neurophysiological processing deficits in long-term schizophrenia and in first hospitalized schizophrenia-spectrum individuals.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2019Article
- Article
- Mooney face stimuli for visual perception research.PloS one · 2018Article
- Computational Modeling of Contrast Sensitivity and Orientation Tuning in First-Episode and Chronic Schizophrenia.Computational psychiatry (Cambridge, Mass.) · 2017Article
- Impaired Tuning of Neural Ensembles and the Pathophysiology of Schizophrenia: A Translational and Computational Neuroscience Perspective.Biological psychiatry · 2017Review
- Searching for Cross-Diagnostic Convergence: Neural Mechanisms Governing Excitation and Inhibition Balance in Schizophrenia and Autism Spectrum Disorders.Biological psychiatry · 2017Review
Corrections and comments
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Authors and funding
13 authors at 8 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Schizophrenia is characterized by dysfunctions in neural circuits that can be investigated with electrophysiological methods, such as EEG and MEG. In the present human study, we examined event-related fields (ERFs), in a sample of medication-naive, first-episode schizophrenia (FE-ScZ) patients (n = 14) and healthy control participants (n = 17) during perception of Mooney faces to investigate the integrity of neuromagnetic responses and their experience-dependent modification. ERF responses were analyzed for M100, M170, and M250 components at the sensor and source levels. In addition, we analyzed peak latency and adaptation effects due to stimulus repetition. FE-ScZ patients were characterized by significantly impaired sensory processing, as indicated by a reduced discrimination index (A'). At the sensor level, M100 and M170 responses in FE-ScZ were within the normal range, whereas the M250 response was impaired. However, source localization revealed widespread elevated activity for M100 and M170 in FE-ScZ and delayed peak latencies for the M100 and M250 responses. In addition, M170 source activity in FE-ScZ was not modulated by stimulus repetitions. The present findings suggest that neural circuits in FE-ScZ may be characterized by a disturbed balance between excitation and inhibition that could lead to a failure to gate information flow and abnormal spreading of activity, which is compatible with dysfunctional glutamatergic neurotransmission.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.