ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Progressive degeneration of dopaminergic neurons through TRP channel-induced cell death.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- Integrating MACSPI and SILAC for Neuron Type-specific Proteomics in Caenorhabditis elegans.Molecular & cellular proteomics : MCP · 2026Article
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- How do necrotic cells expose phosphatidylserine to attract their predators-What's unique and what's in common with apoptotic cells.Frontiers in cell and developmental biology · 2023Review
- Using a quadruplet codon to expand the genetic code of an animal.Nucleic acids research · 2022Article
- Noncanonical necrosis in 2 different cell types in a Caenorhabditis elegans NAD+ salvage pathway mutant.G3 (Bethesda, Md.) · 2022Article
- Quantifying Levels of Dopaminergic Neuron Morphological Alteration and Degeneration in Caenorhabditis elegans.Journal of visualized experiments : JoVE · 2021Article
- Calcium ions trigger the exposure of phosphatidylserine on the surface of necrotic cells.PLoS genetics · 2021Article
- Harnessing the power of genetics: fast forward genetics in Caenorhabditis elegans.Molecular genetics and genomics : MGG · 2021Review
- Calcium, Bioenergetics, and Parkinson's Disease.Cells · 2020Review
- The Role of CaCells · 2020Review
- The Small GTPase RAC1/CED-10 Is Essential in Maintaining Dopaminergic Neuron Function and Survival Against α-Synuclein-Induced Toxicity.Molecular neurobiology · 2018Article
- AG3 (Bethesda, Md.) · 2018Article
- Infection Augments Expression of Mechanosensing Piezo1 Channels in Amyloid Plaque-Reactive Astrocytes.Frontiers in aging neuroscience · 2018Article
- Mutations in Caenorhabditis elegans neuroligin-like glit-1, the apoptosis pathway and the calcium chaperone crt-1 increase dopaminergic neurodegeneration after 6-OHDA treatment.PLoS genetics · 2018Article
- Article
- Nicotinamide is an endogenous agonist for a C. elegans TRPV OSM-9 and OCR-4 channel.Nature communications · 2016Article
- Next-Generation Sequencing-Based Approaches for Mutation Mapping and Identification in Caenorhabditis elegans.Genetics · 2016Review
- Dopamine signaling promotes the xenobiotic stress response and protein homeostasis.The EMBO journal · 2016Article
- The Apoptotic Engulfment Machinery Regulates Axonal Degeneration in C. elegans Neurons.Cell reports · 2016Article
- Evolutionarily conserved mechanisms in calcium handling may underlie intrinsic sensitivity to dopaminergic neuron death.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
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7 authors at 5 institutions in 2 countries.
Funding
Abstract
Progressive neurodegenerative diseases are among the most frequently occurring aging-associated human pathologies. In a screen for Caenorhabditis elegans mutant animals that lack their normal complement of dopaminergic neurons, we identified two strains with progressive loss of dopaminergic neurons during postembryonic life. Through whole-genome sequencing we show that both strains harbor dominant (d), gain-of-function mutations in the Transient Receptor Potential (TRP) mechanosensory channel trp-4, a member of the invertebrate and vertebrate TRPN-type of the TRP family channels. Gain-of-function mutations in TRP channels have not been previously implicated in dopaminergic neuronal degeneration. We show that trp-4(d) induces cell death in dopamine neurons through a defined, calcium-related downstream pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.