Trial reportJournal of the National Cancer Institute2014
Magnetic resonance-guided focused ultrasound for patients with painful bone metastases: phase III trial results.
2 registry-linked trialsOpen access · bronzeAbstract readClinical Trial, Phase IIIMulticenter StudyRandomized Controlled Trial
In one paragraph
Trial report in Journal of the National Cancer Institute, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 108 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
108citing papers in PubMed, 3 pooled it
23.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Multicenter Study of Cryoablation for Palliation of Painful Bone Metastases
A Two-center Phase II, Non-randomized Study of MRgFUS Versus EBRT in Patients With Metastatic Non-spinal Bone Disease: Palliative Strategy for Cancer-Induced Bone Pain
Who cites it
108 citing papers in PubMed, 3 syntheses or guidelines pooled it, 231 citations in OpenAlex.
- Efficacy and safety of magnetic resonance-guided focused ultrasound for the treatment of painful bone metastases: a systematic review and meta-analysis.Skeletal radiology · 2021Pooled it
- The Roles of Magnetic Resonance-Guided Focused Ultrasound in Pain Relief in Patients With Bone Metastases: A Systemic Review and Meta-Analysis.Frontiers in oncology · 2021Pooled it
- Thermal ablation to relieve pain from metastatic bone disease: a systematic review.Skeletal radiology · 2019Pooled it
- Effects of MRgFUS Treatment on Musculoskeletal Pain: Comparison between Bone Metastasis and Chronic Knee/Lumbar Osteoarthritis.Pain research & management · 2019Trial
- Evaluation of Quality of Life Outcomes Following Palliative Treatment of Bone Metastases with Magnetic Resonance-guided High Intensity Focused Ultrasound: An International Multicentre Study.Clinical oncology (Royal College of Radiologists (Great Britain)) · 2018Trial
- Advances in ultrasound-mediated nanozyme systems in therapeutic applications.Ultrasonics sonochemistry · 2026Review
- Interventional Radiology in the Treatment of Musculoskeletal Tumours.Current oncology (Toronto, Ont.) · 2026Review
- Cost-utility of focused ultrasound compared to radiotherapy for Dutch patients with uncomplicated non-spinal bone metastases.The European journal of health economics : HEPAC : health economics in prevention and care · 2026Article
- Revelations of pancreatic cancer treated by high-intensity focused ultrasound.Discover oncology · 2026Article
- Chinese expert consensus on magnetic resonance-guided focused ultrasound surgery for painful bone metastases.Insights into imaging · 2026Article
- Contemporary management strategies for spinal metastases: diagnosis, multidisciplinary approaches, and outcomes - a narrative review.Annals of medicine and surgery (2012) · 2026Review
- Magnetic Resonance-guided Focused Ultrasound Surgery (MRgFUS) for ablation of osteoid osteoma: Long-term results from 10 years of experience.European journal of radiology open · 2025Article
- Interventional Radiology Management of Bone Metastasis Pain: Strategies and Techniques.Cardiovascular and interventional radiology · 2025Review
- Therapeutic Ultrasound for Multimodal Cancer Treatment: A Spotlight on Breast Cancer.Annual review of biomedical engineering · 2025Review
- Overview of Therapeutic Ultrasound Applications and Safety Considerations: 2024 Update.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2025Review
- Using the Tissue Impulse Response Function to Streamline Fractionated MRgFUS-Induced Hyperthermia.Cancers · 2025Article
- Article
- MR Imaging-Guided Focused Ultrasound for Breast Tumors.Magnetic resonance imaging clinics of North America · 2024Review
- Minimally invasive interventional guided imaging therapies of musculoskeletal tumors.Quantitative imaging in medicine and surgery · 2024Review
- Compressive stresses in cancer: characterization and implications for tumour progression and treatment.Nature reviews. Cancer · 2024Review
48 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
17 authors at 4 institutions in 3 countries.
Mark D HurwitzAffiliations of authors: Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA (MDH); Department of Radiology, Brigham and Women's Hospital, Boston, MA (FMF, CMCT); Department of Radiology, Stanford University Medical Center, Stanford, CA (PG); Department of Radiation Oncology and Radiology, N. N. Petrov Institute of Oncology, St. Petersburg, Russian Federation (SK, VT); Department of MRI and FUS, Rostov State Research Institute of Oncology, Rostov on Don, Russian Federation (DI); Department of Medical Imaging, University Health Network, University of Toronto, Toronto, Canada (DG); Department of Oncology, Rambam Medical Center, Haifa, Israel (AK); Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA (JM); University MRI & Diagnositc Imaging Centers, Boca Raton, FL (SDL); Department of Radiology, University of California at San Diego, San Diego, CA (AR); Department of Diagnostic Imaging and Interventional Radiology,H. Lee Moffitt Cancer Center, Tampa, FL (JC); Department of Radiation Oncology, University of Virginia, Charlottesville, VA (JML); Department of Radiological, Oncological, and Pathological Sciences, Sapienza University of Rome, Rome, Italy (AN); Department of Radiation Oncology, Sheba Medical Center, Tel Hashomer, Israel (YI,RMP). mark.hurwitz@jefferson.edu.
Pejman GhanouniAffiliations of authors: Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA (MDH); Department of Radiology, Brigham and Women's Hospital, Boston, MA (FMF, CMCT); Department of Radiology, Stanford University Medical Center, Stanford, CA (PG); Department of Radiation Oncology and Radiology, N. N. Petrov Institute of Oncology, St. Petersburg, Russian Federation (SK, VT); Department of MRI and FUS, Rostov State Research Institute of Oncology, Rostov on Don, Russian Federation (DI); Department of Medical Imaging, University Health Network, University of Toronto, Toronto, Canada (DG); Department of Oncology, Rambam Medical Center, Haifa, Israel (AK); Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA (JM); University MRI & Diagnositc Imaging Centers, Boca Raton, FL (SDL); Department of Radiology, University of California at San Diego, San Diego, CA (AR); Department of Diagnostic Imaging and Interventional Radiology,H. Lee Moffitt Cancer Center, Tampa, FL (JC); Department of Radiation Oncology, University of Virginia, Charlottesville, VA (JML); Department of Radiological, Oncological, and Pathological Sciences, Sapienza University of Rome, Rome, Italy (AN); Department of Radiation Oncology, Sheba Medical Center, Tel Hashomer, Israel (YI,RMP).
Sergey V KanaevAffiliations of authors: Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA (MDH); Department of Radiology, Brigham and Women's Hospital, Boston, MA (FMF, CMCT); Department of Radiology, Stanford University Medical Center, Stanford, CA (PG); Department of Radiation Oncology and Radiology, N. N. Petrov Institute of Oncology, St. Petersburg, Russian Federation (SK, VT); Department of MRI and FUS, Rostov State Research Institute of Oncology, Rostov on Don, Russian Federation (DI); Department of Medical Imaging, University Health Network, University of Toronto, Toronto, Canada (DG); Department of Oncology, Rambam Medical Center, Haifa, Israel (AK); Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA (JM); University MRI & Diagnositc Imaging Centers, Boca Raton, FL (SDL); Department of Radiology, University of California at San Diego, San Diego, CA (AR); Department of Diagnostic Imaging and Interventional Radiology,H. Lee Moffitt Cancer Center, Tampa, FL (JC); Department of Radiation Oncology, University of Virginia, Charlottesville, VA (JML); Department of Radiological, Oncological, and Pathological Sciences, Sapienza University of Rome, Rome, Italy (AN); Department of Radiation Oncology, Sheba Medical Center, Tel Hashomer, Israel (YI,RMP).
Dmitri IozeffiAffiliations of authors: Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA (MDH); Department of Radiology, Brigham and Women's Hospital, Boston, MA (FMF, CMCT); Department of Radiology, Stanford University Medical Center, Stanford, CA (PG); Department of Radiation Oncology and Radiology, N. N. Petrov Institute of Oncology, St. Petersburg, Russian Federation (SK, VT); Department of MRI and FUS, Rostov State Research Institute of Oncology, Rostov on Don, Russian Federation (DI); Department of Medical Imaging, University Health Network, University of Toronto, Toronto, Canada (DG); Department of Oncology, Rambam Medical Center, Haifa, Israel (AK); Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA (JM); University MRI & Diagnositc Imaging Centers, Boca Raton, FL (SDL); Department of Radiology, University of California at San Diego, San Diego, CA (AR); Department of Diagnostic Imaging and Interventional Radiology,H. Lee Moffitt Cancer Center, Tampa, FL (JC); Department of Radiation Oncology, University of Virginia, Charlottesville, VA (JML); Department of Radiological, Oncological, and Pathological Sciences, Sapienza University of Rome, Rome, Italy (AN); Department of Radiation Oncology, Sheba Medical Center, Tel Hashomer, Israel (YI,RMP).
David GianfeliceAffiliations of authors: Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA (MDH); Department of Radiology, Brigham and Women's Hospital, Boston, MA (FMF, CMCT); Department of Radiology, Stanford University Medical Center, Stanford, CA (PG); Department of Radiation Oncology and Radiology, N. N. Petrov Institute of Oncology, St. Petersburg, Russian Federation (SK, VT); Department of MRI and FUS, Rostov State Research Institute of Oncology, Rostov on Don, Russian Federation (DI); Department of Medical Imaging, University Health Network, University of Toronto, Toronto, Canada (DG); Department of Oncology, Rambam Medical Center, Haifa, Israel (AK); Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA (JM); University MRI & Diagnositc Imaging Centers, Boca Raton, FL (SDL); Department of Radiology, University of California at San Diego, San Diego, CA (AR); Department of Diagnostic Imaging and Interventional Radiology,H. Lee Moffitt Cancer Center, Tampa, FL (JC); Department of Radiation Oncology, University of Virginia, Charlottesville, VA (JML); Department of Radiological, Oncological, and Pathological Sciences, Sapienza University of Rome, Rome, Italy (AN); Department of Radiation Oncology, Sheba Medical Center, Tel Hashomer, Israel (YI,RMP).
Fiona Mary FennessyAffiliations of authors: Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA (MDH); Department of Radiology, Brigham and Women's Hospital, Boston, MA (FMF, CMCT); Department of Radiology, Stanford University Medical Center, Stanford, CA (PG); Department of Radiation Oncology and Radiology, N. N. Petrov Institute of Oncology, St. Petersburg, Russian Federation (SK, VT); Department of MRI and FUS, Rostov State Research Institute of Oncology, Rostov on Don, Russian Federation (DI); Department of Medical Imaging, University Health Network, University of Toronto, Toronto, Canada (DG); Department of Oncology, Rambam Medical Center, Haifa, Israel (AK); Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA (JM); University MRI & Diagnositc Imaging Centers, Boca Raton, FL (SDL); Department of Radiology, University of California at San Diego, San Diego, CA (AR); Department of Diagnostic Imaging and Interventional Radiology,H. Lee Moffitt Cancer Center, Tampa, FL (JC); Department of Radiation Oncology, University of Virginia, Charlottesville, VA (JML); Department of Radiological, Oncological, and Pathological Sciences, Sapienza University of Rome, Rome, Italy (AN); Department of Radiation Oncology, Sheba Medical Center, Tel Hashomer, Israel (YI,RMP).
Abraham KutenAffiliations of authors: Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA (MDH); Department of Radiology, Brigham and Women's Hospital, Boston, MA (FMF, CMCT); Department of Radiology, Stanford University Medical Center, Stanford, CA (PG); Department of Radiation Oncology and Radiology, N. N. Petrov Institute of Oncology, St. Petersburg, Russian Federation (SK, VT); Department of MRI and FUS, Rostov State Research Institute of Oncology, Rostov on Don, Russian Federation (DI); Department of Medical Imaging, University Health Network, University of Toronto, Toronto, Canada (DG); Department of Oncology, Rambam Medical Center, Haifa, Israel (AK); Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA (JM); University MRI & Diagnositc Imaging Centers, Boca Raton, FL (SDL); Department of Radiology, University of California at San Diego, San Diego, CA (AR); Department of Diagnostic Imaging and Interventional Radiology,H. Lee Moffitt Cancer Center, Tampa, FL (JC); Department of Radiation Oncology, University of Virginia, Charlottesville, VA (JML); Department of Radiological, Oncological, and Pathological Sciences, Sapienza University of Rome, Rome, Italy (AN); Department of Radiation Oncology, Sheba Medical Center, Tel Hashomer, Israel (YI,RMP).
Joshua E MeyerAffiliations of authors: Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA (MDH); Department of Radiology, Brigham and Women's Hospital, Boston, MA (FMF, CMCT); Department of Radiology, Stanford University Medical Center, Stanford, CA (PG); Department of Radiation Oncology and Radiology, N. N. Petrov Institute of Oncology, St. Petersburg, Russian Federation (SK, VT); Department of MRI and FUS, Rostov State Research Institute of Oncology, Rostov on Don, Russian Federation (DI); Department of Medical Imaging, University Health Network, University of Toronto, Toronto, Canada (DG); Department of Oncology, Rambam Medical Center, Haifa, Israel (AK); Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA (JM); University MRI & Diagnositc Imaging Centers, Boca Raton, FL (SDL); Department of Radiology, University of California at San Diego, San Diego, CA (AR); Department of Diagnostic Imaging and Interventional Radiology,H. Lee Moffitt Cancer Center, Tampa, FL (JC); Department of Radiation Oncology, University of Virginia, Charlottesville, VA (JML); Department of Radiological, Oncological, and Pathological Sciences, Sapienza University of Rome, Rome, Italy (AN); Department of Radiation Oncology, Sheba Medical Center, Tel Hashomer, Israel (YI,RMP).
Suzanne D LeBlangAffiliations of authors: Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA (MDH); Department of Radiology, Brigham and Women's Hospital, Boston, MA (FMF, CMCT); Department of Radiology, Stanford University Medical Center, Stanford, CA (PG); Department of Radiation Oncology and Radiology, N. N. Petrov Institute of Oncology, St. Petersburg, Russian Federation (SK, VT); Department of MRI and FUS, Rostov State Research Institute of Oncology, Rostov on Don, Russian Federation (DI); Department of Medical Imaging, University Health Network, University of Toronto, Toronto, Canada (DG); Department of Oncology, Rambam Medical Center, Haifa, Israel (AK); Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA (JM); University MRI & Diagnositc Imaging Centers, Boca Raton, FL (SDL); Department of Radiology, University of California at San Diego, San Diego, CA (AR); Department of Diagnostic Imaging and Interventional Radiology,H. Lee Moffitt Cancer Center, Tampa, FL (JC); Department of Radiation Oncology, University of Virginia, Charlottesville, VA (JML); Department of Radiological, Oncological, and Pathological Sciences, Sapienza University of Rome, Rome, Italy (AN); Department of Radiation Oncology, Sheba Medical Center, Tel Hashomer, Israel (YI,RMP).
Ann RobertsAffiliations of authors: Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA (MDH); Department of Radiology, Brigham and Women's Hospital, Boston, MA (FMF, CMCT); Department of Radiology, Stanford University Medical Center, Stanford, CA (PG); Department of Radiation Oncology and Radiology, N. N. Petrov Institute of Oncology, St. Petersburg, Russian Federation (SK, VT); Department of MRI and FUS, Rostov State Research Institute of Oncology, Rostov on Don, Russian Federation (DI); Department of Medical Imaging, University Health Network, University of Toronto, Toronto, Canada (DG); Department of Oncology, Rambam Medical Center, Haifa, Israel (AK); Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA (JM); University MRI & Diagnositc Imaging Centers, Boca Raton, FL (SDL); Department of Radiology, University of California at San Diego, San Diego, CA (AR); Department of Diagnostic Imaging and Interventional Radiology,H. Lee Moffitt Cancer Center, Tampa, FL (JC); Department of Radiation Oncology, University of Virginia, Charlottesville, VA (JML); Department of Radiological, Oncological, and Pathological Sciences, Sapienza University of Rome, Rome, Italy (AN); Department of Radiation Oncology, Sheba Medical Center, Tel Hashomer, Israel (YI,RMP).
Junsung ChoiAffiliations of authors: Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA (MDH); Department of Radiology, Brigham and Women's Hospital, Boston, MA (FMF, CMCT); Department of Radiology, Stanford University Medical Center, Stanford, CA (PG); Department of Radiation Oncology and Radiology, N. N. Petrov Institute of Oncology, St. Petersburg, Russian Federation (SK, VT); Department of MRI and FUS, Rostov State Research Institute of Oncology, Rostov on Don, Russian Federation (DI); Department of Medical Imaging, University Health Network, University of Toronto, Toronto, Canada (DG); Department of Oncology, Rambam Medical Center, Haifa, Israel (AK); Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA (JM); University MRI & Diagnositc Imaging Centers, Boca Raton, FL (SDL); Department of Radiology, University of California at San Diego, San Diego, CA (AR); Department of Diagnostic Imaging and Interventional Radiology,H. Lee Moffitt Cancer Center, Tampa, FL (JC); Department of Radiation Oncology, University of Virginia, Charlottesville, VA (JML); Department of Radiological, Oncological, and Pathological Sciences, Sapienza University of Rome, Rome, Italy (AN); Department of Radiation Oncology, Sheba Medical Center, Tel Hashomer, Israel (YI,RMP).
James M LarnerAffiliations of authors: Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA (MDH); Department of Radiology, Brigham and Women's Hospital, Boston, MA (FMF, CMCT); Department of Radiology, Stanford University Medical Center, Stanford, CA (PG); Department of Radiation Oncology and Radiology, N. N. Petrov Institute of Oncology, St. Petersburg, Russian Federation (SK, VT); Department of MRI and FUS, Rostov State Research Institute of Oncology, Rostov on Don, Russian Federation (DI); Department of Medical Imaging, University Health Network, University of Toronto, Toronto, Canada (DG); Department of Oncology, Rambam Medical Center, Haifa, Israel (AK); Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA (JM); University MRI & Diagnositc Imaging Centers, Boca Raton, FL (SDL); Department of Radiology, University of California at San Diego, San Diego, CA (AR); Department of Diagnostic Imaging and Interventional Radiology,H. Lee Moffitt Cancer Center, Tampa, FL (JC); Department of Radiation Oncology, University of Virginia, Charlottesville, VA (JML); Department of Radiological, Oncological, and Pathological Sciences, Sapienza University of Rome, Rome, Italy (AN); Department of Radiation Oncology, Sheba Medical Center, Tel Hashomer, Israel (YI,RMP).
Alessandro NapoliAffiliations of authors: Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA (MDH); Department of Radiology, Brigham and Women's Hospital, Boston, MA (FMF, CMCT); Department of Radiology, Stanford University Medical Center, Stanford, CA (PG); Department of Radiation Oncology and Radiology, N. N. Petrov Institute of Oncology, St. Petersburg, Russian Federation (SK, VT); Department of MRI and FUS, Rostov State Research Institute of Oncology, Rostov on Don, Russian Federation (DI); Department of Medical Imaging, University Health Network, University of Toronto, Toronto, Canada (DG); Department of Oncology, Rambam Medical Center, Haifa, Israel (AK); Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA (JM); University MRI & Diagnositc Imaging Centers, Boca Raton, FL (SDL); Department of Radiology, University of California at San Diego, San Diego, CA (AR); Department of Diagnostic Imaging and Interventional Radiology,H. Lee Moffitt Cancer Center, Tampa, FL (JC); Department of Radiation Oncology, University of Virginia, Charlottesville, VA (JML); Department of Radiological, Oncological, and Pathological Sciences, Sapienza University of Rome, Rome, Italy (AN); Department of Radiation Oncology, Sheba Medical Center, Tel Hashomer, Israel (YI,RMP).
Vladimir G TurkevichAffiliations of authors: Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA (MDH); Department of Radiology, Brigham and Women's Hospital, Boston, MA (FMF, CMCT); Department of Radiology, Stanford University Medical Center, Stanford, CA (PG); Department of Radiation Oncology and Radiology, N. N. Petrov Institute of Oncology, St. Petersburg, Russian Federation (SK, VT); Department of MRI and FUS, Rostov State Research Institute of Oncology, Rostov on Don, Russian Federation (DI); Department of Medical Imaging, University Health Network, University of Toronto, Toronto, Canada (DG); Department of Oncology, Rambam Medical Center, Haifa, Israel (AK); Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA (JM); University MRI & Diagnositc Imaging Centers, Boca Raton, FL (SDL); Department of Radiology, University of California at San Diego, San Diego, CA (AR); Department of Diagnostic Imaging and Interventional Radiology,H. Lee Moffitt Cancer Center, Tampa, FL (JC); Department of Radiation Oncology, University of Virginia, Charlottesville, VA (JML); Department of Radiological, Oncological, and Pathological Sciences, Sapienza University of Rome, Rome, Italy (AN); Department of Radiation Oncology, Sheba Medical Center, Tel Hashomer, Israel (YI,RMP).
Yael InbarAffiliations of authors: Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA (MDH); Department of Radiology, Brigham and Women's Hospital, Boston, MA (FMF, CMCT); Department of Radiology, Stanford University Medical Center, Stanford, CA (PG); Department of Radiation Oncology and Radiology, N. N. Petrov Institute of Oncology, St. Petersburg, Russian Federation (SK, VT); Department of MRI and FUS, Rostov State Research Institute of Oncology, Rostov on Don, Russian Federation (DI); Department of Medical Imaging, University Health Network, University of Toronto, Toronto, Canada (DG); Department of Oncology, Rambam Medical Center, Haifa, Israel (AK); Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA (JM); University MRI & Diagnositc Imaging Centers, Boca Raton, FL (SDL); Department of Radiology, University of California at San Diego, San Diego, CA (AR); Department of Diagnostic Imaging and Interventional Radiology,H. Lee Moffitt Cancer Center, Tampa, FL (JC); Department of Radiation Oncology, University of Virginia, Charlottesville, VA (JML); Department of Radiological, Oncological, and Pathological Sciences, Sapienza University of Rome, Rome, Italy (AN); Department of Radiation Oncology, Sheba Medical Center, Tel Hashomer, Israel (YI,RMP).
Clare Mary C TempanyAffiliations of authors: Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA (MDH); Department of Radiology, Brigham and Women's Hospital, Boston, MA (FMF, CMCT); Department of Radiology, Stanford University Medical Center, Stanford, CA (PG); Department of Radiation Oncology and Radiology, N. N. Petrov Institute of Oncology, St. Petersburg, Russian Federation (SK, VT); Department of MRI and FUS, Rostov State Research Institute of Oncology, Rostov on Don, Russian Federation (DI); Department of Medical Imaging, University Health Network, University of Toronto, Toronto, Canada (DG); Department of Oncology, Rambam Medical Center, Haifa, Israel (AK); Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA (JM); University MRI & Diagnositc Imaging Centers, Boca Raton, FL (SDL); Department of Radiology, University of California at San Diego, San Diego, CA (AR); Department of Diagnostic Imaging and Interventional Radiology,H. Lee Moffitt Cancer Center, Tampa, FL (JC); Department of Radiation Oncology, University of Virginia, Charlottesville, VA (JML); Department of Radiological, Oncological, and Pathological Sciences, Sapienza University of Rome, Rome, Italy (AN); Department of Radiation Oncology, Sheba Medical Center, Tel Hashomer, Israel (YI,RMP).
Raphael M PfefferAffiliations of authors: Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA (MDH); Department of Radiology, Brigham and Women's Hospital, Boston, MA (FMF, CMCT); Department of Radiology, Stanford University Medical Center, Stanford, CA (PG); Department of Radiation Oncology and Radiology, N. N. Petrov Institute of Oncology, St. Petersburg, Russian Federation (SK, VT); Department of MRI and FUS, Rostov State Research Institute of Oncology, Rostov on Don, Russian Federation (DI); Department of Medical Imaging, University Health Network, University of Toronto, Toronto, Canada (DG); Department of Oncology, Rambam Medical Center, Haifa, Israel (AK); Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA (JM); University MRI & Diagnositc Imaging Centers, Boca Raton, FL (SDL); Department of Radiology, University of California at San Diego, San Diego, CA (AR); Department of Diagnostic Imaging and Interventional Radiology,H. Lee Moffitt Cancer Center, Tampa, FL (JC); Department of Radiation Oncology, University of Virginia, Charlottesville, VA (JML); Department of Radiological, Oncological, and Pathological Sciences, Sapienza University of Rome, Rome, Italy (AN); Department of Radiation Oncology, Sheba Medical Center, Tel Hashomer, Israel (YI,RMP).
Imaging Center · USRostov Research Institute of Oncology · RUUniversity of Toronto · CAThomas Jefferson University · US
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPain due to bone metastases is a common cause of cancer-related morbidity, with few options available for patients refractory to medical therapies and who do not respond to radiation therapy. This study assessed the safety and efficacy of magnetic resonance-guided focused ultrasound surgery (MRgFUS), a noninvasive method of thermal tissue ablation for palliation of pain due to bone metastases.
methodsPatients with painful bone metastases were randomly assigned 3:1 to receive MRgFUS sonication or placebo. The primary endpoint was improvement in self-reported pain score without increase of pain medication 3 months after treatment and was analyzed by Fisher's exact test. Components of the response composite, Numerical Rating Scale for pain (NRS) and morphine equivalent daily dose intake, were analyzed by t test and Wilcoxon rank-sum test, respectively. Brief Pain Inventory (BPI-QoL), a measure of functional interference of pain on quality of life, was compared between MRgFUS and placebo by t test. Statistical tests were two-sided.
resultsOne hundred forty-seven subjects were enrolled, with 112 and 35 randomly assigned to MRgFUS and placebo treatments, respectively. Response rate for the primary endpoint was 64.3% in the MRgFUS arm and 20.0% in the placebo arm (P < .001). MRgFUS was also superior to placebo at 3 months on the secondary endpoints assessing worst score NRS (P < .001) and the BPI-QoL (P < .001). The most common treatment-related adverse event (AE) was sonication pain, which occurred in 32.1% of MRgFUS patients. Two patients had pathological fractures, one patient had third-degree skin burn, and one patient suffered from neuropathy. Overall 60.3% of all AEs resolved on the treatment day.
conclusionsThis multicenter phase III trial demonstrated that MRgFUS is a safe and effective, noninvasive treatment for alleviating pain resulting from bone metastases in patients that have failed standard treatments.
Indexed as
AdultAgedAged, 80 and overBone NeoplasmsFemaleHigh-Intensity Focused Ultrasound AblationHumansMagnetic Resonance ImagingMaleMiddle AgedNeoplasmsSingle-Blind MethodUltrasonographyYoung Adult
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Registered trials
NCT02511678ClinicalTrials.gov
NCT03404362ClinicalTrials.gov
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