ArticleJournal of neurophysiology2014
Evidence of calcium-permeable AMPA receptors in dendritic spines of CA1 pyramidal neurons.
Article in Journal of neurophysiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Article
- Possible Role of Cellular Polyamine Metabolism in Neuronal Apoptosis.Current medical science · 2024Article
- A dietary polyphenol metabolite alters CA1 excitability ex vivo and mildly affects cortico-hippocampal field potential generators in anesthetized animals.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Nitric Oxide Regulates GluA2-Lacking AMPAR Contribution to Synaptic Transmission of CA1 Apical but Not Basal Dendrites.Frontiers in synaptic neuroscience · 2021Article
- AMPA-Type Glutamate Receptor Conductance Changes and Plasticity: Still a Lot of Noise.Neurochemical research · 2019Review
- Shank and Zinc Mediate an AMPA Receptor Subunit Switch in Developing Neurons.Frontiers in molecular neuroscience · 2018Article
- SPARC and GluA1-Containing AMPA Receptors Promote Neuronal Health Following CNS Injury.Frontiers in cellular neuroscience · 2018Article
- The Role of Polyamine-Dependent Facilitation of Calcium Permeable AMPARs in Short-Term Synaptic Enhancement.Frontiers in cellular neuroscience · 2018Review
- The Role of Calcium-Permeable AMPARs in Long-Term Potentiation at Principal Neurons in the Rodent Hippocampus.Frontiers in synaptic neuroscience · 2018Review
- Synapse-specific expression of calcium-permeable AMPA receptors in neocortical layer 5.The Journal of physiology · 2016Article
- Auxiliary Subunit GSG1L Acts to Suppress Calcium-Permeable AMPA Receptor Function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Sensory gating of an embryonic zebrafish interneuron during spontaneous motor behaviors.Frontiers in neural circuits · 2014Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
GluA2-lacking, calcium-permeable α-amino-3-hydroxy-5-methylisoxazole-4-propionate receptors (AMPARs) have unique properties, but their presence at excitatory synapses in pyramidal cells is controversial. We have tested certain predictions of the model that such receptors are present in CA1 cells and show here that the polyamine spermine, but not philanthotoxin, causes use-dependent inhibition of synaptically evoked excitatory responses in stratum radiatum, but not s. oriens, in cultured and acute hippocampal slices. Stimulation of single dendritic spines by photolytic release of caged glutamate induced an N-methyl-d-aspartate receptor-independent, use- and spermine-sensitive calcium influx only at apical spines in cultured slices. Bath application of glutamate also triggered a spermine-sensitive influx of cobalt into CA1 cell dendrites in s. radiatum. Responses of single apical, but not basal, spines to photostimulation displayed prominent paired-pulse facilitation (PPF) consistent with use-dependent relief of cytoplasmic polyamine block. Responses at apical dendrites were diminished, and PPF was increased, by spermine. Intracellular application of pep2m, which inhibits recycling of GluA2-containing AMPARs, reduced apical spine responses and increased PPF. We conclude that some calcium-permeable, polyamine-sensitive AMPARs, perhaps lacking GluA2 subunits, are present at synapses on apical dendrites of CA1 pyramidal cells, which may allow distinct forms of synaptic plasticity and computation at different sets of excitatory inputs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.