ArticleHuman molecular genetics2014
Multi-ethnic fine-mapping of 14 central adiposity loci.
Article in Human molecular genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 6 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Trans-ethnic meta-analysis of rare variants in sequencing association studies.Biostatistics (Oxford, England) · 2021Pooled it
- A fine-mapping study of central obesity loci incorporating functional annotation and imputation.European journal of human genetics : EJHG · 2018Pooled it
- Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels.Human molecular genetics · 2017Pooled it
- Generalization and fine mapping of European ancestry-based central adiposity variants in African ancestry populations.International journal of obesity (2005) · 2017Pooled it
- Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in Erythropoiesis.American journal of human genetics · 2017Pooled it
- Trans-ethnic Meta-analysis and Functional Annotation Illuminates the Genetic Architecture of Fasting Glucose and Insulin.American journal of human genetics · 2016Pooled it
- Genome-wide association study in Japanese females identifies fifteen novel skin-related trait associations.Scientific reports · 2018Trial
- Aging reveals a sex-dependent susceptibility of sarcospan-deficient mice to cardiometabolic disease.American journal of physiology. Heart and circulatory physiology · 2024Article
- Review
- A lead candidate functional single nucleotide polymorphism within the WARS2 gene associated with waist-hip-ratio does not alter RNA stability.Biochimica et biophysica acta. Gene regulatory mechanisms · 2020Article
- EDAR, LYPLAL1, PRDM16, PAX3, DKK1, TNFSF12, CACNA2D3, and SUPT3H gene variants influence facial morphology in a Eurasian population.Human genetics · 2019Article
- Dopamine gene methylation patterns are associated with obesity markers and carbohydrate intake.Brain and behavior · 2018Article
- Genetic variants in SEC16B are associated with body composition in black South Africans.Nutrition & diabetes · 2018Article
- Current Challenges and New Opportunities for Gene-Environment Interaction Studies of Complex Diseases.American journal of epidemiology · 2017Article
- Analysis of Gene Candidate SNP and Ancestral Origin Associated to Obesity and Postoperative Weight Loss in a Cohort of Obese Patients Undergoing RYGB.Obesity surgery · 2017Article
- Genetic effects influencing risk for major depressive disorder in China and Europe.Translational psychiatry · 2017Article
- Archaic Adaptive Introgression in TBX15/WARS2.Molecular biology and evolution · 2017Article
- Dissecting the genetics of complex traits using summary association statistics.Nature reviews. Genetics · 2017Review
- Signatures of Archaic Adaptive Introgression in Present-Day Human Populations.Molecular biology and evolution · 2017Article
- Mouse Models of Human GWAS Hits for Obesity and Diabetes in the Post Genomic Era: Time for Reevaluation.Frontiers in endocrinology · 2017Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
The Genetic Investigation of Anthropometric Traits (GIANT) consortium identified 14 loci in European Ancestry (EA) individuals associated with waist-to-hip ratio (WHR) adjusted for body mass index. These loci are wide and narrowing the signals remains necessary. Twelve of 14 loci identified in GIANT EA samples retained strong associations with WHR in our joint EA/individuals of African Ancestry (AA) analysis (log-Bayes factor >6.1). Trans-ethnic analyses at five loci (TBX15-WARS2, LYPLAL1, ADAMTS9, LY86 and ITPR2-SSPN) substantially narrowed the signals to smaller sets of variants, some of which are in regions that have evidence of regulatory activity. By leveraging varying linkage disequilibrium structures across different populations, single-nucleotide polymorphisms (SNPs) with strong signals and narrower credible sets from trans-ethnic meta-analysis of central obesity provide more precise localizations of potential functional variants and suggest a possible regulatory role. Meta-analysis results for WHR were obtained from 77 167 EA participants from GIANT and 23 564 AA participants from the African Ancestry Anthropometry Genetics Consortium. For fine mapping we interrogated SNPs within ± 250 kb flanking regions of 14 previously reported index SNPs from loci discovered in EA populations by performing trans-ethnic meta-analysis of results from the EA and AA meta-analyses. We applied a Bayesian approach that leverages allelic heterogeneity across populations to combine meta-analysis results and aids in fine-mapping shared variants at these locations. We annotated variants using information from the ENCODE Consortium and Roadmap Epigenomics Project to prioritize variants for possible functionality.
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