Trial reportMolecular carcinogenesis2015
Pilot clinical study of the effects of ginger root extract on eicosanoids in colonic mucosa of subjects at increased risk for colorectal cancer.
Trial report in Molecular carcinogenesis, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Ginger on Human Health: A Comprehensive Systematic Review of 109 Randomized Controlled Trials.Nutrients · 2020Pooled it
- Effect of ginger supplementation on the fecal microbiome in subjects with prior colorectal adenoma.Scientific reports · 2024Trial
- An Adaptive Bayesian Design for Personalized Dosing in a Cancer Prevention Trial.American journal of preventive medicine · 2020Trial
- Polypharmacology and Neuroprotective Effects of Gingerol in Alzheimer's Disease.Molecular neurobiology · 2025Review
- Interplay Between Traditional and Scientific Knowledge: Phytoconstituents and Their Roles in Lung and Colorectal Cancer Signaling Pathways.Biomolecules · 2025Review
- Low-Dose Oral Ginger Improves Daily Symptom Scores in Asthma.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Exploring the therapeutic potential of edible vegetables, fruits, and spices against cancer in various cell lines.Journal of Cancer · 2024Article
- Ginger as an anticolorectal cancer spice: A systematic review of in vitro to clinical evidence.Food science & nutrition · 2023Review
- The Chemical Signatures of Water Extract ofMolecules (Basel, Switzerland) · 2022Article
- COVID-19, cytokines, inflammation, and spices: How are they related?Life sciences · 2021Review
- Medicinal chemistry inspired by ginger: exploring the chemical space around 6-gingerol.RSC advances · 2021Review
- Ginger in gastrointestinal disorders: A systematic review of clinical trials.Food science & nutrition · 2019Review
- Plants of the Genus Zingiber as a Source of Bioactive Phytochemicals: From Tradition to Pharmacy.Molecules (Basel, Switzerland) · 2017Review
- Colors of vegetables and fruits and the risks of colorectal cancer.World journal of gastroenterology · 2017Article
- Spices for Prevention and Treatment of Cancers.Nutrients · 2016Review
- Anticancer Effect of Ginger Extract against Pancreatic Cancer Cells Mainly through Reactive Oxygen Species-Mediated Autotic Cell Death.PloS one · 2015Article
- Ginger and its constituents: role in prevention and treatment of gastrointestinal cancer.Gastroenterology research and practice · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Colorectal cancer (CRC) remains a significant cause of mortality. Inhibitors of cyclooxygenase (COX) and thus prostaglandin E2, are promising CRC preventives, but have significant toxicities. Ginger has been shown to inhibit COX, to decrease the incidence and multiplicity of adenomas, and decrease PGE2 concentrations in subjects at normal risk for CRC. This study was conducted to determine the effects of 2.0 g/d of ginger given orally on the levels of PGE2, leukotriene B4 (LTB4), 13-hydroxy-octadecadienoic acids, and 5-, 12-, & 15-hydroxyeicosatetraenoic acid, in the colonic mucosa of subjects at increased risk for CRC. We randomized 20 subjects to 2.0 g/d ginger or placebo for 28 d. At baseline and Day 28, a flexible sigmoidoscopy was used to obtain colon biopsies. A liquid chromatography mass spectrometry method was used to determine eicosanoid levels in the biopsies, and levels were expressed per amount of protein or free arachidonic acid (AA). There was a significant decrease in AA between baseline and Day 28 (P = 0.05) and significant increase in LTB4 (P = 0.04) when normalized to protein, in subjects treated with ginger versus placebo. No other changes in eicosanoids were observed. There was no difference between the groups in total adverse events (AE; P = 0.06). Ginger lacks the ability to decrease eicosanoid levels in people at increased risk for CRC. Ginger did appear to be both tolerable and safe; and could have chemopreventive effects through other mechanisms. Further investigation should focus on other markers of CRC risk in those at increased CRC risk.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.