ReviewCurrent pain and headache reports2014
Preventive drugs in childhood and adolescent migraine.
Review in Current pain and headache reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03055767 (Effectiveness of Onabotulinumtoxin A), which is not on this map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effectiveness of Onabotulinumtoxin A (Botox) in Pediatric Patients Experiencing Migraines: A Randomized Double Blinded Placebo Cross-over Study in the Pediatric Pain Population
Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- A Randomized Trial to Evaluate OnabotulinumtoxinA for Prevention of Headaches in Adolescents With Chronic Migraine.Headache · 2020Trial
- Efficacy and safety of magnesium prophylaxis in children with migraine without aura.Northern clinics of Istanbul · 2025Article
- Cyproheptadine Treatment in Children and Adolescents with Migraine: A Retrospective Study in Japan.Neurology international · 2024Article
- Global Burden of Headache Disorders in Children and Adolescents 2007-2017.International journal of environmental research and public health · 2020Article
- Management of Chronic Migraine in Children and Adolescents: A Brief Discussion on Preventive Therapies.Paediatric drugs · 2020Review
- Vestibular Syndromes in Childhood and Adolescence.International archives of otorhinolaryngology · 2020Article
- Further Evidence that Onabotulinum Toxin is a Viable Treatment Option for Pediatric Chronic Migraine Patients.Cureus · 2019Article
- When to Consider Prophylactic Antimigraine Therapy in Children with Migraine.Current treatment options in neurology · 2019Review
- Management of Episodic Migraine in Children and Adolescents: a Practical Approach.Current neurology and neuroscience reports · 2018Review
- Pharmacotherapy for Persistent Posttraumatic Headaches in Children and Adolescents: A Brief Review of the Literature.Paediatric drugs · 2018Review
- Non-pharmacological Approaches for Headaches in Young Age: An Updated Review.Frontiers in neurology · 2018Review
- The use of nutraceutics in children's and adolescent's headache.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2017Article
- New advances in prevention of migraine. Review of current practice and recent advances.Neurosciences (Riyadh, Saudi Arabia) · 2016Review
- The optimal management of headaches in children and adolescents.Therapeutic advances in neurological disorders · 2016Review
- Prophylactic Drug Treatment of Migraine in Children and Adolescents: An Update.Current pain and headache reports · 2016Review
- Adolescent migraine: diagnostic and therapeutic approaches.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2015Article
- Psychiatric comorbidity in childhood and adolescence headache.Current pain and headache reports · 2015Review
- Spectrum of complicated migraine in children: A common profile in aid to clinical diagnosis.World journal of clinical pediatrics · 2015Review
- Treatment of pediatric migraine.Current treatment options in neurology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While headaches in children are quite common, the study and characterization of headache disorders in the pediatric age group has historically been limited. In the absence of controlled studies on prophylactic treatment of the primary headache disorders in this age group, the diagnosis of childhood migraine rests on criteria similar to those in adults. Data from adult studies are often extrapolated and applied to children as well. Although it appears that many preventive agents are safe in children, none are currently FDA-approved for this age group. As a result, despite experiencing significant disability, the vast majority of children who present to their physician with migraine headache do not receive prophylactic therapy. Furthermore, controlled clinical trials investigating the use of both abortive and preventive medications in children have suffered from high placebo response rates. The shorter duration of headaches and other characteristic features seen in children are such that designing randomized controlled trials in this age group is more problematic and limiting. As such, treatment practices vary widely, even among specialists, due to the absence of evidence-based guidelines from clinical trials.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.