ArticlePharmaceutical research2014
Development of thermostable lyophilized inactivated polio vaccine.
Article in Pharmaceutical research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Real-Time Single-Aggregate Analysis of Vaccine Antigen Stability via Stochastic Electrochemical Blocking.The AAPS journal · 2026Article
- Zeolitic Imidazolate Frameworks Allows for the Thermal Stabilization of Live Viral Vaccine in the Absence of Lyophilization.ACS omega · 2025Article
- Non-Invasive Vaccines: Challenges in Formulation and Vaccine Adjuvants.Pharmaceutics · 2023Review
- Current and next-generation formulation strategies for inactivated polio vaccines to lower costs, increase coverage, and facilitate polio eradication.Human vaccines & immunotherapeutics · 2022Review
- Advances in gene-based vaccine platforms to address the COVID-19 pandemic.Advanced drug delivery reviews · 2021Review
- Dose-Sparing Intradermal DTaP-sIPV Immunization With a Hollow Microneedle Leads to Superior Immune Responses.Frontiers in microbiology · 2021Article
- Development of an Orodispersible Film Containing Stabilized Influenza Vaccine.Pharmaceutics · 2020Article
- Thin silk fibroin films as a dried format for temperature stabilization of inactivated polio vaccine.Vaccine · 2020Article
- Development of a thermostable microneedle patch for polio vaccination.Drug delivery and translational research · 2019Article
- Article
- Stabilized single-injection inactivated polio vaccine elicits a strong neutralizing immune response.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Development of Stabilizing Formulations of a Trivalent Inactivated Poliovirus Vaccine in a Dried State for Delivery in the Nanopatch™ Microprojection Array.Journal of pharmaceutical sciences · 2018Article
- Incompatibility of lyophilized inactivated polio vaccine with liquid pentavalent whole-cell-pertussis-containing vaccine.Vaccine · 2016Article
- Thermostabilization of inactivated polio vaccine in PLGA-based microspheres for pulsatile release.Journal of controlled release : official journal of the Controlled Release Society · 2016Article
- Inactivated poliovirus type 2 vaccine delivered to rat skin via high density microprojection array elicits potent neutralising antibody responses.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of current study was to develop a dried inactivated polio vaccine (IPV) formulation with minimal loss during the drying process and improved stability when compared with the conventional liquid IPV.
methodsExtensive excipient screening was combined with the use of a Design of Experiment (DoE) approach in order to achieve optimal results with high probability.
resultsAlthough it was shown earlier that the lyophilization of a trivalent IPV while conserving its antigenicity is challenging, we were able to develop a formulation that showed minimal loss of potency during drying and subsequent storage at higher temperatures.
conclusionThis study showed the potential of a highly stable and safe lyophilized polio vaccine, which might be used in developing countries without the need of a cold-chain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.