ArticlePsychopharmacology2014
Anxiolytic effects of oxytocin in cue-induced cocaine seeking behavior in rats.
Article in Psychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 51 citations in OpenAlex.
- Oxytocin attenuates neural response to emotional faces in social drinkers: an fMRI study.European archives of psychiatry and clinical neuroscience · 2021Trial
- Environmental enrichment enhances ethanol preference over social reward in male swiss mice: Involvement of oxytocin-dopamine interactions.Neuropharmacology · 2024Article
- Peripherally restricted oxytocin is sufficient to reduce food intake and motivation, while CNS entry is required for locomotor and taste avoidance effects.Diabetes, obesity & metabolism · 2023Article
- The Role of Oxytocin and Vasopressin in Drug-Induced Reward-Implications for Social and Non-Social Factors.Biomolecules · 2023Review
- Ventral pallidal regulation of motivated behaviors and reinforcement.Frontiers in neural circuits · 2023Review
- Brain systems in cocaine abstinence-induced anxiety-like behavior in rodents: A review.Addiction neuroscience · 2022Article
- Paternal Cocaine in Mice Alters Social Behavior and Brain Oxytocin Receptor Density in First Generation Offspring.Neuroscience · 2022Article
- Intranasal oxytocin may improve odds of abstinence in cocaine-dependent patients: results from a preliminary study.Drug and alcohol dependence reports · 2022Article
- Article
- Oxytocin and Addiction: Potential Glutamatergic Mechanisms.International journal of molecular sciences · 2021Review
- Neural mechanisms underlying incubation of methamphetamine craving: A mini-review.Pharmacology, biochemistry, and behavior · 2020Review
- Sex-dimorphic role of prefrontal oxytocin receptors in social-induced facilitation of extinction in juvenile rats.Translational psychiatry · 2020Article
- Oxytocin Attenuates Expression, but Not Acquisition, of Sucrose Conditioned Place Preference in Rats.Frontiers in behavioral neuroscience · 2020Article
- Decreased Blood Levels of Oxytocin in Ketamine-Dependent Patients During Early Abstinence.Frontiers in psychiatry · 2018Article
- Oxytocin Reduces Cocaine Cued Fos Activation in a Regionally Specific Manner.The international journal of neuropsychopharmacology · 2017Article
- Oxytocin Acts in Nucleus Accumbens to Attenuate Methamphetamine Seeking and Demand.Biological psychiatry · 2017Article
- Neuroprotective effects of melatonin administration against chronic immobilization stress in rats.International journal of physiology, pathophysiology and pharmacology · 2017Article
- Oxytocin for the treatment of drug and alcohol use disorders.Behavioural pharmacology · 2016Review
- Oxytocin decreases cocaine taking, cocaine seeking, and locomotor activity in female rats.Experimental and clinical psychopharmacology · 2016Article
- Targeting the Oxytocin System to Treat Addictive Disorders: Rationale and Progress to Date.CNS drugs · 2016Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
rationaleOxytocin (OT) is a neuropeptide previously related to reward, learning, memory, and stress, events associated with cocaine addiction. OT has shown anxiolytic properties in different animal models of anxiety. Moreover, previous data have demonstrated an increase in mRNA OT levels within the nucleus accumbens (NAc) following acute and chronic cocaine exposure in rats. Therefore, OT might play a modulatory role in the rewarding properties of cocaine.
objectivesThe present set of experiments aims to examine the role of OT on environmentally elicited cocaine-seeking behavior and whether OT could reduce anxiety associated with this behavior.
methodsSeparate groups of rats were trained in a cue-elicited cocaine-seeking behavior paradigm. Prior to the reinstatement phase, animals received microinfusions of artificial cerebrospinal fluid (aCSF), OT, OT agonist (TgOT), or OT antagonist (OTA) within the intracerebral ventricular intracerebroventricular (ICV) system. To test OT anxiolytic effects in reinstatement behavior, separate groups of animals were trained in a cue-elicited cocaine-seeking behavior protocol or in a cocaine-conditioning paradigm. At the end of each behavioral training, all animals were ICV pretreated with aCSF or OT, and then exposed to an elevated plus maze.
resultsResults showed that OT and TgOT pretreatment significantly reduced reinstatement of cocaine-seeking behavior. Most significantly, OT treatment reduced the anxiety triggered by cue-induced reinstatement conditions and cocaine-paired conditioned locomotion.
conclusionsThe present study demonstrates for the first time that OT actions within the brain mediate the anxiety response triggered by cues previously paired with cocaine intake.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.