SynthesisTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2014
The polymorphism interleukin-8 -251A/T is associated with a significantly increased risk of cancers from a meta-analysis.
Synthesis in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Association between interleukin-8 -251A/T polymorphism and the risk of tuberculosis: A meta-analysis.The Journal of international medical research · 2020Pooled it
- Interleukin-8 Gene -251 A/T (rs4073) Polymorphism and Coronary Artery Disease Risk: A Meta-Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2019Pooled it
- Interleukin-8 -251A/T gene polymorphism and lung cancer susceptibility: a meta-analysis.Journal of cellular and molecular medicine · 2015Pooled it
- Thymic function as a central determinant of immune competence and clinical outcomes.Seminars in immunopathology · 2026Review
- Six IL-8 gene polymorphisms and the entire cancer susceptibility according to a comprehensive analysis especially in prostate cancer.Clinics (Sao Paulo, Brazil) · 2026Article
- Genetic Variants of Interleukin-8 and Interleukin-16 and Their Association with Cervical Cancer Risk.Life (Basel, Switzerland) · 2025Article
- Anticancer Properties of Garlic and Ginger Extract in Colon Cancer Cell Line.Asian Pacific journal of cancer prevention : APJCP · 2024Article
- Article
- The contribution of interleukin-8 genotypes and expression to nasopharyngeal cancer susceptibility in Taiwan.Medicine · 2018Article
- Cytokine Gene Polymorphisms Associated With Various Domains of Quality of Life in Women With Breast Cancer.Journal of pain and symptom management · 2018Article
- Polymorphisms of TNF-BioMed research international · 2018Article
- PharmGKB summary: pazopanib pathway, pharmacokinetics.Pharmacogenetics and genomics · 2017Review
- IL-8 -251A/T and +781C/T polymorphisms were associated with risk of breast cancer in a Chinese population.International journal of clinical and experimental pathology · 2017Article
- Limb-bud and Heart (LBH) functions as a tumor suppressor of nasopharyngeal carcinoma by inducing G1/S cell cycle arrest.Scientific reports · 2015Article
- Association between Interleukin-8-251A/T polymorphism and gastric cancer susceptibility: a meta-analysis based on 5286 cases and 8000 controls.International journal of clinical and experimental medicine · 2015Article
- Association between interferon gamma 13-CA-repeats polymorphism and metastasis of nasopharyngeal carcinoma in a population of Northern China.International journal of clinical and experimental pathology · 2015Article
- Effects of six months of Yoga on inflammatory serum markers prognostic of recurrence risk in breast cancer survivors.SpringerPlus · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Emerging evidences show that interleukin-8 (IL-8) has important regulatory functions in tumorigenesis. IL-8 -251A/T is a single nucleotide polymorphism in the promoter region of the IL-8 gene and affects IL-8 production. Analysis of previous studies on the association of -251A/T polymorphism with different cancer types remained to be illustrated. To further assess the effect of -251A/T polymorphism on cancer risks, we performed this meta-analysis, up to November 2013, of 12,917 cases with different cancer types and 17,689 controls from 47 published case-control designed studies. Statistical analyses were performed using STATA 11.0 software. Crude odds ratios (ORs) with 95 % confidence intervals (CIs) were used to assess the strength of associations. ORs with 95 % CIs for IL-8 -251A/T polymorphism and cancer were estimated using fixed- and random-effects models when appropriate. Significantly increased risks were found in overall under the models of A allele vs. T allele, AA vs. TT, and AA vs. AT/TT. Significantly elevated risks were observed in breast cancer under the models of A allele vs. T allele, AT vs. TT, AA/AT vs. TT, and AA vs. AT/TT, and in nasopharyngeal carcinoma under the models of AT vs. TT, AA/AT vs. TT, and AA vs. AT/TT. We found that significantly elevated risks were observed in the Asian population and hospital-based studies in all comparison models. Thus, this meta-analysis indicates that IL-8 -251A/T polymorphism is associated with a significantly increased risk of cancers and may provide evidence-based medical certificate to study the cancer susceptibility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.