ArticlePsychological science2014
A developmental pathway from early life stress to inflammation: the role of negative health behaviors.
Article in Psychological science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 3 of them syntheses that pooled it.
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Who cites it
41 citing papers in PubMed, 3 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Links of Adversity in Childhood With Mental and Physical Health Outcomes: A Systematic Review of Longitudinal Mediating and Moderating Mechanisms.Trauma, violence & abuse · 2023Pooled it
- Inflammation and depression in young people: a systematic review and proposed inflammatory pathways.Molecular psychiatry · 2022Pooled it
- Early life adversity exposure and circulating markers of inflammation in children and adolescents: A systematic review and meta-analysis.Brain, behavior, and immunity · 2020Pooled it
- Inflammatory diet mediates the relationship between early life stress and inflammation in adolescents.Brain, behavior, and immunity · 2026Article
- Peripheral inflammation mediates the relationship between early life stress and alcohol use.Psychopharmacology · 2026Article
- Environmental unpredictability predicts positive social risk taking through neural cognitive control.Social cognitive and affective neuroscience · 2026Article
- Article
- Metabolic biomarkers for predicting onset and severity of CAR-T therapy-induced cytokine release syndrome in multiple myeloma.Frontiers of medicine · 2025Article
- Associations of lifetime stressors and health behaviors with inflammation in young adults previously placed in youth residential care.Brain, behavior, & immunity - health · 2025Article
- Early life adversity and risk for non-communicable health outcomes: challenges and opportunities for a maturing field.BMC medicine · 2025Review
- The embodiment of parental death in early life through accelerated epigenetic aging: Implications for understanding how parental death before 18 shapes age-related health risk among older adults.SSM - population health · 2024Article
- Chronic social stress in early life can predispose mice to antisocial maltreating behavior.Encephalitis (Seoul, Korea) · 2024Article
- Profiles of historical loss and childhood trauma as predictors of mental and cardiometabolic health in American Indian adults.SSM. Mental health · 2023Article
- Language Preference and its Moderating Role in Coping with Stress: The Hispanic Community Health Study/Study of Latinos.Medical research archives · 2023Article
- Gender- and age-specific associations of childhood maltreatment with peripheral serum inflammatory cytokines in middle school students.Frontiers in immunology · 2023Article
- Chronic social stress during early development is involved in antisocial maltreatment behavior in mice.Encephalitis (Seoul, Korea) · 2022Article
- The Mediating Effect of Inflammation between the Dietary and Health-Related Behaviors and Metabolic Syndrome in Adolescence.Nutrients · 2022Article
- Non-invasive diagnosis and monitoring tool of children's mental health: A point-of-care immunosensor for IL-6 quantification in saliva samples.Frontiers in neuroscience · 2022Article
- A review and novel theoretical model of how negative emotions influence inflammation: The critical role of emotion regulation.Brain, behavior, & immunity - health · 2021Article
- Inflammation is associated with future depressive symptoms among older adults.Brain, behavior, & immunity - health · 2021Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Early life stressors are associated with elevated inflammation, a key physiological risk factor for disease. However, the mechanisms by which early stress leads to inflammation remain largely unknown. Using a longitudinal data set, we examined smoking, alcohol consumption, and body mass index (BMI) as health-behavior pathways by which early adversity might lead to inflammation during young adulthood. Contemporaneously measured early adversity predicted increased BMI and smoking but not alcohol consumption, and these effects were partially accounted for by chronic stress in young adulthood. Higher BMI in turn predicted higher levels of soluble tumor necrosis factor receptor type II (sTNF-RII) and C-reactive protein (CRP), and smoking predicted elevated sTNF-RII. These findings establish that early adversity contributes to inflammation in part through ongoing stress and maladaptive health behavior. Given that maladaptive health behaviors portend inflammation in young adulthood, they serve as promising targets for interventions designed to prevent the negative consequences of early adversity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.