Observational studyIntensive care medicine2014
Dysglycaemia in the critically ill and the interaction of chronic and acute glycaemia with mortality.
Observational study in Intensive care medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02516358 (Glycaemic Alterations in ICU), which is not on this map. Cited by 99 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Glycaemic Alterations in ICU: an Observational, Prospective Cohort Study
Who cites it
99 citing papers in PubMed, 3 syntheses or guidelines pooled it, 226 citations in OpenAlex.
- Systematic review of incretin therapy during peri-operative and intensive care.Critical care (London, England) · 2018Pooled it
- Glycaemic control targets after traumatic brain injury: a systematic review and meta-analysis.Critical care (London, England) · 2018Pooled it
- Stress hyperglycaemia in critically ill patients and the subsequent risk of diabetes: a systematic review and meta-analysis.Critical care (London, England) · 2016Pooled it
- Nomogram for prediction of severe community-acquired pneumonia development in diabetic patients: a multicenter study.BMC pulmonary medicine · 2022Trial
- Individualised versus conventional glucose control in critically-ill patients: the CONTROLING study-a randomized clinical trial.Intensive care medicine · 2021Trial
- Severe and multiple hypoglycemic episodes are associated with increased risk of death in ICU patients.Critical care (London, England) · 2015Trial
- Effects of glucose-dependent insulinotropic polypeptide on gastric emptying, glycaemia and insulinaemia during critical illness: a prospective, double blind, randomised, crossover study.Critical care (London, England) · 2015Trial
- Association of Postoperative Stress Hyperglycemia Ratio with Suspected Infection, Culture Positivity, Sepsis, and Septic Shock in 1408 Patients After Cranial Neurosurgery.Journal of clinical medicine · 2026Article
- Clarifying the impact of diabetes on ALD-ACLF outcomes: strengths and avenues for refinement.Hepatology international · 2026Article
- A Clinical Predictor of Lung Molecular Endotype Identifies Heterogeneity in Corticosteroid Response in Severe COVID-19: an Emulated Target Trial.medRxiv : the preprint server for health sciences · 2026Article
- Development and validation of glucose trajectory subphenotypes in critically ill patients on early enteral nutrition: a retrospective cohort study.Scientific reports · 2026Article
- Prognostic Value of Stress-Induced Hyperglycemia in High-Acuity Emergency Department Patients.Journal of clinical medicine · 2026Article
- Stress hyperglycemia ratio improves machine learning-based mortality risk prediction in critically ill COVID-19 patients: a multicenter retrospective study.BMC infectious diseases · 2026Article
- Endocrinologist-led glucose management in the emergency ICU: a retrospective before-after study.Frontiers in endocrinology · 2026Article
- Dysglycaemia and the interaction of chronic and acute glycaemia with mortality post cardiac surgery.Scientific reports · 2025Article
- Joint impact of stress hyperglycaemic ratio and glycaemic variability in patients with ischaemic stroke and machine learning for mortality prediction.BMC neurology · 2025Article
- Association of stress hyperglycemia ratio with hospital mortality and acute kidney injury in patients with transfusion.Clinical and experimental nephrology · 2025Article
- Critical care nutrition and the legacy of Rinaldo Bellomo.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2025Review
- The role of the leukocyte glucose index in predicting clinical outcomes in acute methanol toxicity.Toxicology reports · 2025Article
- Cardiac arrhythmia and hypoglycaemia among individuals with and without diabetes receiving haemodialysis (the CADDY study): a Danish multicentre cohort study.Diabetologia · 2025Observational
39 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeHyperglycaemia is common in the critically ill. The objectives of this study were to determine the prevalence of critical illness-associated hyperglycaemia (CIAH) and recognised and unrecognised diabetes in the critically ill as well as to evaluate the impact of premorbid glycaemia on the association between acute hyperglycaemia and mortality.
methodsIn 1,000 consecutively admitted patients we prospectively measured glycated haemoglobin (HbA1c) on admission, and blood glucose concentrations during the 48 h after admission, to the intensive care unit. Patients with blood glucose ≥7.0 mmol/l when fasting or ≥11.1 mmol/l during feeding were deemed hyperglycaemic. Patients with acute hyperglycaemia and HbA1c <6.5% (48 mmol/mol) were categorised as 'CIAH', those with known diabetes as 'recognised diabetes', and those with HbA1c ≥6.5% but no previous diagnosis of diabetes as 'unrecognised diabetes'. The remainder were classified as 'normoglycaemic'. Hospital mortality, HbA1c and acute peak glycaemia were assessed using a logistic regression model.
resultsOf 1,000 patients, 498 (49.8%) had CIAH, 220 (22%) had recognised diabetes, 55 (5.5%) had unrecognised diabetes and 227 (22.7%) were normoglycaemic. The risk of death increased by approximately 20% for each increase in acute glycaemia of 1 mmol/l in patients with CIAH and those with diabetes and HbA1c levels <7% (53 mmol/mol), but not in patients with diabetes and HbA1c ≥7%. This association was lost when adjusted for severity of illness.
conclusionsCritical illness-associated hyperglycaemia is the most frequent cause of hyperglycaemia in the critically ill. Peak glucose concentrations during critical illness are associated with increased mortality in patients with adequate premorbid glycaemic control, but not in patients with premorbid hyperglycaemia. Optimal glucose thresholds in the critically ill may, therefore, be affected by premorbid glycaemia.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.