ArticlePloS one2014
Survival in HIV-infected patients after a cancer diagnosis in the cART Era: results of an italian multicenter study.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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25 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Human immunodeficiency virus infection and mortality risk among lung cancer patients: A systematic review and meta-analysis.Medicine · 2018Pooled it
- Torque Teno Virus (TTV) Plasma Load and Immune Reconstitution in People Living with HIV: A Systematic Review.Microorganisms · 2026Review
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- Female Genital Schistosomiasis: A Neglected among the Neglected Tropical Diseases.Microorganisms · 2024Review
- The Trends and Risk Factors of AIDS-Defining Cancers and Non-AIDS-Defining Cancers in Adults Living with and without HIV: A Narrative Review.Journal of cancer epidemiology · 2024Review
- Overview of virus and cancer relationships. Position paper.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2021Article
- Survival of south african women with breast cancer receiving anti-retroviral therapy for HIV.Breast (Edinburgh, Scotland) · 2021Article
- The effect of non-AIDS-defining cancers on people living with HIV.The Lancet. Oncology · 2021Review
- Cause-specific mortality after diagnosis of cancer among HIV-positive patients: A collaborative analysis of cohort studies.International journal of cancer · 2020Article
- Predictors of Mortality From a Population-Based Cancer Registry Data in Jos, Nigeria: A Resource-Limited Setting.Frontiers in medicine · 2020Article
- CD4/CD8 Ratio and CD4 Nadir Predict Mortality Following Noncommunicable Disease Diagnosis in Adults Living with HIV.AIDS research and human retroviruses · 2019Article
- Brief Report: Malignancies in Adults Living With HIV in Asia.Journal of acquired immune deficiency syndromes (1999) · 2019Article
- Breast Cancer and HIV in Sub-Saharan Africa: A Complex Relationship.Journal of global oncology · 2018Review
- Survival after cancer diagnosis in a cohort of HIV-positive individuals in Latin America.Infectious agents and cancer · 2018Article
- [Clinicpathological features and survival of patients with AIDS related non-Hodgkin's lymphoma].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2017Article
- Cervical cancer patients presentation and survival in the only oncology referral hospital, Ethiopia: a retrospective cohort study.Infectious agents and cancer · 2017Article
- Lung cancer in persons with HIV.Current opinion in HIV and AIDS · 2017Review
- Prevalence and mortality of cancer among HIV-infected inpatients in Beijing, China.BMC infectious diseases · 2016Article
- Efficacy of an Anti-transferrin Receptor 1 Antibody Against AIDS-related Non-Hodgkin Lymphoma: A Brief Communication.Journal of immunotherapy (Hagerstown, Md. : 1997) · 2015Article
- Non-AIDS definings malignancies among human immunodeficiency virus-positive subjects: Epidemiology and outcome after two decades of HAART era.World journal of virology · 2015Review
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Authors and funding
17 authors at 9 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesWe studied survival and associated risk factors in an Italian nationwide cohort of HIV-infected individuals after an AIDS-defining cancer (ADC) or non-AIDS-defining cancer (NADC) diagnosis in the modern cART era.
methodsMulti-center, retrospective, observational study of HIV patients included in the MASTER Italian Cohort with a cancer diagnosis from January 1998 to September 2012. Malignancies were divided into ADC or NADC on the basis of the Centre for Disease Control-1993 classification. Recurrence of cancer and metastases were excluded. Survivals were estimated according to the Kaplan-Meier method and compared according to the log-rank test. Statistically significant variables at univariate analysis were entered in a multivariate Cox regression model.
resultsEight hundred and sixty-six cancer diagnoses were recorded among 13,388 subjects in the MASTER Database after 1998: 435 (51%) were ADCs and 431 (49%) were NADCs. Survival was more favorable after an ADC diagnosis than a NADC diagnosis (10-year survival: 62.7%±2.9% vs. 46%±4.2%; p = 0.017). Non-Hodgkin lymphoma had lower survival rates than patients with Kaposi sarcoma or cervical cancer (10-year survival: 48.2%±4.3% vs. 72.8%±4.0% vs. 78.5%±9.9%; p<0.001). Regarding NADCs, breast cancer showed better survival (10-year survival: 65.1%±14%) than lung cancer (1-year survival: 28%±8.7%), liver cancer (5-year survival: 31.9%±6.4%) or Hodgkin lymphoma (10-year survival: 24.8%±11.2%). Lower CD4+ count and intravenous drug use were significantly associated with decreased survival after ADCs or NADCs diagnosis. Exposure to cART was found to be associated with prolonged survival only in the case of ADCs.
conclusionscART has improved survival in patients with an ADC diagnosis, whereas the prognosis after a diagnosis of NADCs is poor. Low CD4+ counts and intravenous drug use are risk factors for survival following a diagnosis of ADCs and Hodgkin lymphoma in the NADC group.
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