ArticlePloS one2014
Determinants of renal tissue oxygenation as measured with BOLD-MRI in chronic kidney disease and hypertension in humans.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
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Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it, 90 citations in OpenAlex.
- Renal blood oxygenation level-dependent magnetic resonance imaging to measure renal tissue oxygenation: a statement paper and systematic review.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2018Pooled it
- Separate and combined effects of semaglutide and empagliflozin on kidney oxygenation and perfusion in people with type 2 diabetes: a randomised trial.Diabetologia · 2023Trial
- Acute and Chronic Effects of SGLT2 Inhibitor Empagliflozin on Renal Oxygenation and Blood Pressure Control in Nondiabetic Normotensive Subjects: A Randomized, Placebo-Controlled Trial.Journal of the American Heart Association · 2020Trial
- Glomerulonephritis through the lens of ultrasound and radiology.World journal of nephrology · 2026Review
- Contribution of tissue oximetry to the assessment of renal dysfunction in abdominal compartment syndrome: an experimental canine study.Frontiers in surgery · 2026Article
- Renal Metabolic Rate of Oxygen in Response to Hypoxia Challenges by Means of Quantitative MRI in Humans.NMR in biomedicine · 2025Article
- Medullary sponge kidney: in-depth phenotyping for a better understanding of functional and structural abnormalities.Journal of nephrology · 2025Article
- Magnetic resonance imaging of renal oxygenation.Nature reviews. Nephrology · 2025Review
- MR T2* Map to Predict Worsening Hypertension Control: A Preliminary Study.Life (Basel, Switzerland) · 2025Article
- Renal microcirculation and mechanisms in diabetic kidney disease.Frontiers in endocrinology · 2025Review
- Multiparametric MRI: can we assess renal function differently?Clinical kidney journal · 2025Review
- MRI of kidney size matters.Magma (New York, N.Y.) · 2024Review
- Sodium-dependent glucose transporter 2 inhibitor alleviates renal lipid deposition and improves renal oxygenation levels in newly diagnosed type 2 diabetes mellitus patients: a randomized controlled trial.Diabetology & metabolic syndrome · 2023Article
- Renal MRI: From Nephron to NMR Signal.Journal of magnetic resonance imaging : JMRI · 2023Review
- Determinants of Renal Micro-Perfusion as Assessed with Contrast-Enhanced Ultrasound in Healthy Males and Females.Journal of clinical medicine · 2023Article
- Fibrosis imaging with multiparametric proton and sodium MRI in pig injury models.NMR in biomedicine · 2023Article
- Kidney oxygenation, perfusion and blood flow in people with and without type 1 diabetes.Clinical kidney journal · 2022Article
- Repeatability of Contrast-Enhanced Ultrasound to Determine Renal Cortical Perfusion.Diagnostics (Basel, Switzerland) · 2022Article
- Acute effects of dapagliflozin on renal oxygenation and perfusion in type 1 diabetes with albuminuria: A randomised, double-blind, placebo-controlled crossover trial.EClinicalMedicine · 2021Article
- Hip Position Acutely Affects Oxygenation and Perfusion of Kidney Grafts as Measured by Functional Magnetic Resonance Imaging Methods-The Bent Knee Study.Frontiers in medicine · 2021Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Experimentally renal tissue hypoxia appears to play an important role in the pathogenesis of chronic kidney disease (CKD) and arterial hypertension (AHT). In this study we measured renal tissue oxygenation and its determinants in humans using blood oxygenation level-dependent magnetic resonance imaging (BOLD-MRI) under standardized hydration conditions. Four coronal slices were selected, and a multi gradient echo sequence was used to acquire T2* weighted images. The mean cortical and medullary R2* values ( = 1/T2*) were calculated before and after administration of IV furosemide, a low R2* indicating a high tissue oxygenation. We studied 195 subjects (95 CKD, 58 treated AHT, and 42 healthy controls). Mean cortical R2 and medullary R2* were not significantly different between the groups at baseline. In stimulated conditions (furosemide injection), the decrease in R2* was significantly blunted in patients with CKD and AHT. In multivariate linear regression analyses, neither cortical nor medullary R2* were associated with eGFR or blood pressure, but cortical R2* correlated positively with male gender, blood glucose and uric acid levels. In conclusion, our data show that kidney oxygenation is tightly regulated in CKD and hypertensive patients at rest. However, the metabolic response to acute changes in sodium transport is altered in CKD and in AHT, despite preserved renal function in the latter group. This suggests the presence of early renal metabolic alterations in hypertension. The correlations between cortical R2* values, male gender, glycemia and uric acid levels suggest that these factors interfere with the regulation of renal tissue oxygenation.
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