Evidence map›Paper›PMID 24760013›Full record

ArticlePloS one2014

Influence of anodal transcranial direct current stimulation (tDCS) over the right angular gyrus on brain activity during rest.

Benjamin Clemens, Stefanie Jung, Gianluca Mingoia, David Weyer, Frank Domahs, Klaus Willmes

Abstract read
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Trial
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Benjamin ClemensDepartment of Psychiatry, Psychotherapy and Psychosomatics, Medical School, RWTH Aachen University, Aachen, Germany; Brain Imaging Facility, Interdisciplinary Center for Clinical Research, Medical School, RWTH Aachen University, Aachen, Germany; Neurological Clinic, Section Neuropsychology, Medical School, RWTH Aachen University, Aachen, Germany.
Stefanie JungDepartment of Psychology, Eberhard Karls University, Tübingen, Germany; Knowledge Media Research Center, IWM-KMRC, Tübingen, Germany.
Gianluca MingoiaBrain Imaging Facility, Interdisciplinary Center for Clinical Research, Medical School, RWTH Aachen University, Aachen, Germany.
David WeyerBrain Imaging Facility, Interdisciplinary Center for Clinical Research, Medical School, RWTH Aachen University, Aachen, Germany.
Frank DomahsDepartment of Germanic Linguistics, Philipps-University Marburg, Marburg, Germany.
Klaus WillmesBrain Imaging Facility, Interdisciplinary Center for Clinical Research, Medical School, RWTH Aachen University, Aachen, Germany; Neurological Clinic, Section Neuropsychology, Medical School, RWTH Aachen University, Aachen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although numerous studies examined resting-state networks (RSN) in the human brain, so far little is known about how activity within RSN might be modulated by non-invasive brain stimulation applied over parietal cortex. Investigating changes in RSN in response to parietal cortex stimulation might tell us more about how non-invasive techniques such as transcranial direct current stimulation (tDCS) modulate intrinsic brain activity, and further elaborate our understanding of how the resting brain responds to external stimulation. Here we examined how activity within the canonical RSN changed in response to anodal tDCS applied over the right angular gyrus (AG). We hypothesized that changes in resting-state activity can be induced by a single tDCS session and detected with functional magnetic resonance imaging (fMRI). Significant differences between two fMRI sessions (pre-tDCS and post-tDCS) were found in several RSN, including the cerebellar, medial visual, sensorimotor, right frontoparietal, and executive control RSN as well as the default mode and the task positive network. The present results revealed decreased and increased RSN activity following tDCS. Decreased RSN activity following tDCS was found in bilateral primary and secondary visual areas, and in the right putamen. Increased RSN activity following tDCS was widely distributed across the brain, covering thalamic, frontal, parietal and occipital regions. From these exploratory results we conclude that a single session of anodal tDCS over the right AG is sufficient to induce large-scale changes in resting-state activity. These changes were localized in sensory and cognitive areas, covering regions close to and distant from the stimulation site.

Indexed as

AdultElectric StimulationHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedParietal LobeRestTranscranial Direct Current Stimulation

Identifiers

PMID24760013
PMCPMC3997501

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.