ArticlePloS one2014
Insights into nasal carriage of Staphylococcus aureus in an urban and a rural community in Ghana.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
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Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Mupirocin-resistantAntimicrobial resistance and infection control · 2018Pooled it
- Antimicrobial resistance in Africa: a systematic review.BMC infectious diseases · 2017Pooled it
- Infection of neonates withMicrobiology spectrum · 2025Article
- Clonal Complexes Distribution ofAntibiotics (Basel, Switzerland) · 2023Article
- Antimicrobial resistance and genomic analysis of staphylococci isolated from livestock and farm attendants in Northern Ghana.BMC microbiology · 2022Article
- Methicillin-resistantFuture science OA · 2022Article
- Nasopharyngeal colonisation dynamics of bacterial pathogens in patients with fever in rural Burkina Faso: an observational study.BMC infectious diseases · 2022Observational
- Occurrence of influenza and bacterial infections in cancer patients receiving radiotherapy in Ghana.PloS one · 2022Article
- Article
- Ecology and Genetic Lineages of NasalPathogens (Basel, Switzerland) · 2021Review
- Methicillin-ResistantPathogens (Basel, Switzerland) · 2021Article
- Molecular epidemiology of Staphylococcus aureus in African children from rural and urban communities with atopic dermatitis.BMC infectious diseases · 2021Article
- Nasopharyngeal Carriage of Methicillin-ResistantInfectious disease reports · 2021Article
- Whole Genome Sequencing and Antimicrobial Resistance ofPathogens (Basel, Switzerland) · 2021Article
- Nasopharyngeal Carriage and Antimicrobial Susceptibility Profile ofPathogens (Basel, Switzerland) · 2021Article
- Methicillin-resistant Staphylococcus aureus (MRSA) nasal carriage among patients with diabetes at the Korle Bu Teaching Hospital.PloS one · 2021Article
- Decolonization of Human Anterior Nares of Staphylococcus aureus with Use of a Glycerol Monolaurate Nonaqueous Gel.mSphere · 2020Article
- Article
- Antibiotic resistance patterns in human, animal, food and environmental isolates in Ghana: a review.The Pan African medical journal · 2020Review
- COVID-19 pandemic and antimicrobial resistance: Another call to strengthen laboratory diagnostic capacity in Africa.African journal of laboratory medicine · 2020Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The epidemiology of Staphylococcus aureus in the community in Ghana was never investigated prior to this study. The aims of the study were: i) to assess prevalence of nasal S. aureus carriage in Ghanaian people living in an urban and a rural area, and ii) to identify phenotypic and genotypic traits of strains isolated from the two communities. Nasal swabs were collected from healthy individuals living in an urban community situated in the suburb of the capital city, Accra (n = 353) and in a rural community situated in the Dangme-West district (n = 234). The overall prevalence of nasal carriage was 21% with a significantly higher prevalence in the urban (28%) than in the rural community (11%) (p<0.0001). The levels of antimicrobial resistance were generally low (<5%) except for penicillin (91%) and tetracycline (25%). The only two (0.3%) MRSA carriers were individuals living in the urban area and had been exposed to hospitals within the last 12 months prior to sampling. Resistance to tetracycline (p = 0.0009) and presence of Panton-Valentine leukocidin (PVL) gene (p = 0.02) were significantly higher among isolates from the rural community compared to isolates from the urban community. Eleven MLST clonal complexes (CC) were detected based on spa typing of the 124 S. aureus isolates from the two communities: CC8 (n = 36), CC152 (n = 21), CC45 (n = 21), CC15 (n = 18), CC121 (n = 6), CC97 (n = 6), CC30 (n = 5), CC5 (n = 5), CC508 (n = 4), CC9 (n = 1), and CC707 (n = 1). CC8 and CC45 were less frequent in the rural area than in the urban area (p = 0.02). These results reveal remarkable differences regarding carriage prevalence, tetracycline resistance, PVL content and clonal distribution of S. aureus in the two study populations. Future research may be required to establish whether such differences in nasal S. aureus carriage are linked to socio-economic differences between urban and rural communities in this African country.
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