ArticleGastroenterology report2013
Immune response after laparoscopic colectomy for cancer: a review.
Article in Gastroenterology report, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Impact of laparoscopic versus open surgery on humoral immunity in patients with colorectal cancer: a systematic review and meta-analysis.Surgical endoscopy · 2024Pooled it
- Comparison of postoperative lymphocytes and interleukins between laparoscopy-assisted and open radical gastrectomy for early gastric cancer.The Journal of international medical research · 2019Trial
- Laparoscopic Surgery Versus Open Surgery for Colorectal Cancer: Impacts on Natural Killer Cells.Cancer control : journal of the Moffitt Cancer CenterTrial
- Clinical and economic effects of the transformation from an open to a laparoscopic center for colorectal surgery.Langenbeck's archives of surgery · 2025Article
- Maintenance of caecal homeostasis by diverse adaptive immune cells in the rhesus macaque.Clinical & translational immunology · 2024Article
- Influence of Laparoscopic Surgery on Cellular Immunity in Colorectal Cancer: A Systematic Review and Meta-Analysis.Cancers · 2023Review
- Short-term clinical effects and inflammatory response of natural orifice specimen extraction surgery versus conventional laparoscopic-assisted surgery for the treatment of sigmoid and rectal cancer.Journal of gastrointestinal oncology · 2023Article
- Laparoscopic-Assisted Colorectal Resection Can Reduce the Inhibition of Immune Function Compared with Conventional Open Surgery: A Retrospective Clinical Study.Journal of clinical medicine · 2023Article
- Monitoring Pre- and Post-Operative Immune Alterations in Patients With Locoregional Colorectal Cancer Who Underwent Laparoscopy by Single-Cell Mass Cytometry.Frontiers in immunology · 2022Article
- Laparoscopic colorectal cancer surgery reduces the adverse impacts of sarcopenia on postoperative outcomes: a propensity score-matched analysis.Surgical endoscopy · 2020Article
- Risk of Graft Failure in Kidney Recipients with Cured Post-Transplant Cancer.Journal of Korean medical science · 2020Article
- Laparoscopic surgery for rectal cancer reveals comparable oncological outcome even in context of worse short-term results-long-term analysis of nearly 500 patients from two high-volume centers.International journal of colorectal disease · 2019Article
- Development of a Hemodynamic Model Using Routine Monitoring Parameters for Nociceptive Responses Evaluation During Surgery Under General Anesthesia.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Perioperative Increase in Neutrophil CD64 Expression is an Indicator for Intra-abdominal Infection after Colorectal Cancer Surgery.Radiology and oncology · 2017Article
- Postoperative Albumin Drop Is a Marker for Surgical Stress and a Predictor for Clinical Outcome: A Pilot Study.Gastroenterology research and practice · 2016Article
- Evaluation of immune responses of gastric cancer patients treated by laparoscopic and open gastrectomy.Medical oncology (Northwood, London, England) · 2015Article
- Postoperative pain in Sprague Dawley rats after liver biopsy by laparotomy versus laparoscopy.Lab animal · 2015Article
- Surgical stress response after colorectal resection: a comparison of robotic, laparoscopic, and open surgery.Techniques in coloproctology · 2015Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimColorectal cancer (CRC) is the third leading cause of cancer mortality worldwide and laparoscopic colectomy has been established as equivalent to the open approach in terms of oncological results and patients' safety. Survival benefits have been reported in favor of laparoscopic colectomy (LC) in stage III CRC patients. Different immune responses after surgery, in terms of innate and cellular immunity, may potentially explain some of the reported differences. This review summarizes the literature on differences in immune response after the laparoscopic and the open approach for CRC. MATERIALS AND
methodsA literature search of electronic databases was conducted and all studies published on 'colorectal cancer', 'laparoscopic and open colectomy' 'immune response' and 'surgical stress laparoscopy versus open' were collected. Among these, the ones referring to CRC and those that had any clinical relevance offering information on perioperative parameters were used.
resultsDespite the heterogeneity of studies, they support the view that innate immune response is activated to a greater degree in open colectomy (OC), which may be related to the more extensive trauma and surgical stress. On the other hand, cellular immunity is better preserved after LC. These differences are more pronounced in the immediate postoperative period.
conclusionsLC has been related to decreased up-regulation of innate immunity and better-preserved cellular immunity. The latter may be related to better anti-tumor activity and may be beneficial in terms of oncological survival in a subgroup of LC patients.
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