Evidence map›Paper›PMID 24759799›Full record

ArticlePloS one2014

A comparison of vasopressin, terlipressin, and lactated ringers for resuscitation of uncontrolled hemorrhagic shock in an animal model.

Chien-Chang Lee, Meng-Tse Gabriel Lee, Shy-Shin Chang, Si-Huei Lee, Yu-Chi Huang, Chia-Hung Yo, Shih-Hao Lee, Shyr-Chyr Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 19 citations in OpenAlex.

  1. Trial
  2. Hemodynamic rescue after blast injury: intravenous administration outperforms intramuscular vasopressin in a swine model.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Chien-Chang LeeDepartment of Emergency Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Meng-Tse Gabriel LeeDepartment of Emergency Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Shy-Shin ChangGraduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan; Department of Family Medicine and Emergency Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Si-Huei LeeDepartment of Rehabilitation and Physical Medicine, National Yang-Ming University and Taipei Veterans General Hospital, National Yang-Ming University, Taipei, Taiwan; Center for Geriatrics and Gerontology, Taipei Veterans General Hospital, National Yang-Ming University, Taipei, Taiwan.
Yu-Chi HuangDepartment of Emergency Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Chia-Hung YoDepartment of Emergency Medicine, Far Eastern Memorial Hospital, Taipei, Taiwan.
Shih-Hao LeeDepartment of Emergency Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Shyr-Chyr ChenDepartment of Emergency Medicine, National Taiwan University Hospital, Taipei, Taiwan.
National Taiwan University Hospital · TWChang Gung Memorial Hospital · TWFar Eastern Memorial Hospital · TWNational Yang Ming Chiao Tung University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThe aim of this study is to compare the effect of lactated ringer (LR), vasopressin (Vaso) or terlipressin (Terli) on uncontrolled hemorrhagic shock (UHS) in rats.

methods48 rats were divided into four treatment groups for UHS study. Vaso group was given bolus vasopressin (0.8 U/kg); the Terli group was given bolus terlipressin (15 mcg/kg); LR group was given LR and the sham group was not given anything. Mean arterial pressure (MAP), serum lactate level, plasma cytokine levels, lung injury and mortality are investigated for these different treatment groups.

resultsCompared with LR group, vasopressin and terlipressin-treated groups were associated with higher MAP, lowered mortality rates, less lung injury, lowered serum lactate level, less proinflammatory and more anti-inflammatory cytokine production at certain time points. Comparing between vasopressin and terlipressin treated groups, there is no statistical difference in mortality rates, lung injury, serum lactate level and cytokine level. However, there is a difference in the length of time in maintaining a restored level of MAP (80 to 110 mmHg). The terlipressin treated rats can maintain this restored level of MAP for 45 minutes, but the vasopressin treated rats can only maintain this restored level of MAP for 5 minutes before decreasing gradually to the MAP observed in LR group (40 mmHg).

conclusionEarly optimization of hemodynamics with terlipressin or vasopressin in an animal model of UHS was associated with improved hemodynamics and inflammatory cytokine profile than the LR control. Compared with vasopressin, terlipressin has the advantage of ease of use and sustained effects.

Indexed as

AnimalsDisease Models, AnimalIsotonic SolutionsLypressinMaleRatsRats, WistarRinger's LactateShock, HemorrhagicTerlipressinVasopressinsIsotonic SolutionsLypressinRinger's LactateTerlipressinVasopressins

Identifiers

PMID24759799
PMCPMC3997410
OpenAlexW2015800171

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.