ArticleJournal of clinical microbiology2014
Norovirus GII.4 detection in environmental samples from patient rooms during nosocomial outbreaks.
Article in Journal of clinical microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Foodborne and Food-Handler Norovirus Outbreaks: A Systematic Review.Foodborne pathogens and disease · 2018Pooled it
- Aerosol Transmission of Norovirus.Viruses · 2024Review
- Norovirus attribution study: Detection of norovirus from the commercial food preparation environment in outbreak and non-outbreak premises.Journal of applied microbiology · 2022Article
- Unveiling of Pyrimidindinones as Potential Anti-Norovirus Agents-A Pharmacoinformatic-Based Approach.Molecules (Basel, Switzerland) · 2022Article
- Risk factors for norovirus infection in healthcare workers during nosocomial outbreaks: a cross-sectional study.Antimicrobial resistance and infection control · 2021Article
- Development of a recombinase-aided amplification assay for rapid detection of human norovirus GII.4.BMC infectious diseases · 2021Article
- Sources of Airborne Norovirus in Hospital Outbreaks.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Article
- Identification of a norovirus outbreak on a hematopoietic stem cell transplant unit and development and implementation of a novel infection prevention algorithm for controlling transmission.Infection control and hospital epidemiology · 2020Article
- Comparison of Swab Sampling Methods for Norovirus Recovery on Surfaces.Food and environmental virology · 2018Article
- Detection of Pathogenic Viruses in the Ambient Air in Seoul, Korea.Food and environmental virology · 2018Article
- Healthcare-associated infections: potential for prevention through vaccination.Therapeutic advances in vaccines and immunotherapy · 2018Review
- Resistance of Enteric Viruses on Fomites.Intervirology · 2018Review
- Airborne or Fomite Transmission for Norovirus? A Case Study Revisited.International journal of environmental research and public health · 2017Article
- Slow Clearance of Norovirus following Infection with Emerging Variants of Genotype GII.4 Strains.Journal of clinical microbiology · 2017Article
- Generic aspects of the airborne spread of human pathogens indoors and emerging air decontamination technologies.American journal of infection control · 2016Review
- Contamination of healthcare workers' mobile phones by epidemic viruses.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2016Article
- The Where is Norovirus Control Lost (WINCL) Study: an enhanced surveillance project to identify norovirus index cases in care settings in the UK and Ireland.Journal of infection prevention · 2016Article
- Structural Evolution of the Emerging 2014-2015 GII.17 Noroviruses.Journal of virology · 2015Article
- Burden of norovirus in healthcare facilities and strategies for outbreak control.The Journal of hospital infection · 2015Review
- Norovirus in healthcare settings.Current opinion in infectious diseases · 2014Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Norovirus (NoV) is an important cause of nosocomial gastroenteric outbreaks. This 5-month study was designed to characterize NoV contamination and airborne dispersal in patient rooms during hospital outbreaks. Air vents, overbed tables, washbasins, dust, and virus traps designed to collect charged particles from the air were swabbed to investigate the possibility of NoV contamination in patient rooms during outbreaks in seven wards and in an outbreak-free ward. Symptomatic inpatients were also sampled. Nucleic acid extracts of the samples were examined for NoV RNA using genogroup I (GI) and GII real-time reverse transcription-PCR (RT-PCR). The NoV strains were characterized by RT-PCR, sequencing, and phylogenetic analysis of the RNA-dependent RNA-polymerase-N/S capsid-coding region (1,040 nucleotides [nt]). Patient strains from two outbreaks in one ward were sequenced across the RNA-dependent-RNA-polymerase major capsid-coding region (2.5 kb), including the hypervariable P2 domain. In the outbreak wards, NoV GII was detected in 48 of 101 (47%) environmental swabs and 63 of 108 patients (58%); NoV genotype II.4 was sequenced from 18 environmental samples, dust (n = 8), virus traps (n = 4), surfaces (n = 6), and 56 patients. In contrast, NoV GII was detected in 2 (GII.4) of 28 (7%) environmental samples and in 2 (GII.6 and GII.4) of 17 patients in the outbreak-free ward. Sequence analyses revealed a high degree of similarity (>99.5%, 1,040 nt) between NoV GII.4 environmental and patient strains from a given ward at a given time. The strains clustered on 11 subbranches of the phylogenetic tree, with strong correlations to time and place. The high nucleotide similarity between the NoV GII.4 strains from patients and their hospital room environment provided molecular evidence of GII.4 dispersal in the air and dust; therefore, interventional cleaning studies are justified.
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