Evidence map›Paper›PMID 24759411›Full record

ArticleNature2014

Mammalian Y chromosomes retain widely expressed dosage-sensitive regulators.

Daniel W Bellott, Jennifer F Hughes, Helen Skaletsky, Laura G Brown, Tatyana Pyntikova, Ting-Jan Cho, Natalia Koutseva, Sara Zaghlul, Tina Graves, Susie Rock and 20 more

Erratum issuedOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 391 papers.

0numbers the graph read from it
0cells of the map it votes in
391citing papers in PubMed
44.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

391 citing papers in PubMed, 664 citations in OpenAlex.

  1. Article
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  9. Genes · 2026
    Article
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  12. Review
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331 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

30 authors at 3 institutions in 1 country.

Daniel W BellottWhitehead Institute, Howard Hughes Medical Institute, & Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA.
Jennifer F HughesWhitehead Institute, Howard Hughes Medical Institute, & Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA.
Helen SkaletskyWhitehead Institute, Howard Hughes Medical Institute, & Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA.
Laura G BrownWhitehead Institute, Howard Hughes Medical Institute, & Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA.
Tatyana PyntikovaWhitehead Institute, Howard Hughes Medical Institute, & Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA.
Ting-Jan ChoWhitehead Institute, Howard Hughes Medical Institute, & Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA.
Natalia KoutsevaWhitehead Institute, Howard Hughes Medical Institute, & Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA.
Sara ZaghlulWhitehead Institute, Howard Hughes Medical Institute, & Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA.
Tina GravesThe Genome Institute, Washington University School of Medicine, St. Louis, Missouri 63108, USA.
Susie RockThe Genome Institute, Washington University School of Medicine, St. Louis, Missouri 63108, USA.
Colin KremitzkiThe Genome Institute, Washington University School of Medicine, St. Louis, Missouri 63108, USA.
Robert S FultonThe Genome Institute, Washington University School of Medicine, St. Louis, Missouri 63108, USA.
Shannon DuganHuman Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA.
Yan DingHuman Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA.
Donna MortonHuman Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA.
Ziad KhanHuman Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA.
Lora LewisHuman Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA.
Christian BuhayHuman Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA.
Qiaoyan WangHuman Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA.
Jennifer WattHuman Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA.
Michael HolderHuman Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA.
Sandy LeeHuman Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA.
Lynne NazarethHuman Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA.
Jessica AlföldiWhitehead Institute, Howard Hughes Medical Institute, & Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA.
Steve RozenWhitehead Institute, Howard Hughes Medical Institute, & Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA.
Donna M MuznyHuman Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA.
Wesley C WarrenThe Genome Institute, Washington University School of Medicine, St. Louis, Missouri 63108, USA.
Richard A GibbsHuman Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA.
Richard K WilsonThe Genome Institute, Washington University School of Medicine, St. Louis, Missouri 63108, USA.
David C PageWhitehead Institute, Howard Hughes Medical Institute, & Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA.
Baylor College of Medicine · USWhitehead Institute for Biomedical Research · USWashington University in St. Louis · US

Funding

Large Scale Genome SequencingU54HG003079 · NHGRI · WASHINGTON UNIVERSITY · PI DUTCHER, SUSAN K · 2004 to 2016
$445.7M
The Human Genome Sequencing CenterU54HG003273 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI GIBBS, RICHARD A · 2004 to 2015
$341.3M
WNV REPLIVAX VACCINE IN NON-HUMAN PRIMATESP51RR013986 · NCRR · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI GAUDUIN, MARIE-CLAIRE ELISABETH · 1999 to 2011
$79.1M
Howard Hughes Medical InstituteNCRR NIH HHS P51 RR013986NHGRI NIH HHS U54 HG003079NHGRI NIH HHS U54 HG003273
6 · The paper itself

Abstract

The human X and Y chromosomes evolved from an ordinary pair of autosomes, but millions of years ago genetic decay ravaged the Y chromosome, and only three per cent of its ancestral genes survived. We reconstructed the evolution of the Y chromosome across eight mammals to identify biases in gene content and the selective pressures that preserved the surviving ancestral genes. Our findings indicate that survival was nonrandom, and in two cases, convergent across placental and marsupial mammals. We conclude that the gene content of the Y chromosome became specialized through selection to maintain the ancestral dosage of homologous X-Y gene pairs that function as broadly expressed regulators of transcription, translation and protein stability. We propose that beyond its roles in testis determination and spermatogenesis, the Y chromosome is essential for male viability, and has unappreciated roles in Turner's syndrome and in phenotypic differences between the sexes in health and disease.

Indexed as

Evolution, MolecularAnimalsChromosomes, Human, XChromosomes, Human, YDiseaseFemaleGene DosageGene Expression RegulationHealthHumansMaleMammalsMarsupialiaMolecular Sequence AnnotationMolecular Sequence DataProtein Biosynthesis

Identifiers

PMID24759411
PMCPMC4139287
OpenAlexW2089920619

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.