Evidence map›Paper›PMID 24759206›Full record

Trial reportMucosal immunology2014

Dendritic cells from aged subjects contribute to chronic airway inflammation by activating bronchial epithelial cells under steady state.

S Prakash, S Agrawal, H Vahed, M Ngyuen, L BenMohamed, L BenMohamad, S Gupta, A Agrawal

Erratum issuedOpen access · bronzeAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Mucosal immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Aging and lung diseases: Unraveling mechanisms and therapeutic targets.Chinese medical journal pulmonary and critical care medicine · 2025
    Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Review
  15. Article
  16. Review
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

  • Erratum issued
    BenMohamad, L [corrected to BenMohamed, L]
5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

S PrakashDivision of Basic and Clinical Immunology, Department of Medicine, University of California-Irvine, Irvine, California, USA.
S AgrawalDivision of Basic and Clinical Immunology, Department of Medicine, University of California-Irvine, Irvine, California, USA.
H VahedCellular and Molecular Immunology Laboratory, Gavin Herbert Eye Institute, University of California-Irvine, Irvine, California, USA.
M NgyuenDivision of Basic and Clinical Immunology, Department of Medicine, University of California-Irvine, Irvine, California, USA.
L BenMohamed
L BenMohamadCellular and Molecular Immunology Laboratory, Gavin Herbert Eye Institute, University of California-Irvine, Irvine, California, USA.
S GuptaDivision of Basic and Clinical Immunology, Department of Medicine, University of California-Irvine, Irvine, California, USA.
A AgrawalDivision of Basic and Clinical Immunology, Department of Medicine, University of California-Irvine, Irvine, California, USA.
University of California, Irvine · US

Funding

Therapeutic Ocular HSV Vaccine in HLA Transgenic RabbitsR01EY019896 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI BENMOHAMED, LBACHIR · 2010 to 2025
$5.1M
Ocular Mucsoal Immunity Induced by HSV-1 LipopeptidesR01EY014900 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI BENMOHAMED, LBACHIR · 2003 to 2014
$3.1M
Blockade of T-cell Co-Inhibitory Pathways & Immunotherapy to Prevent Ocular HerpeR01EY024618 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI BENMOHAMED, LBACHIR · 2014 to 2016
$1.2M
NEI NIH HHS R01 EY014900NEI NIH HHS R01 EY019896NEI NIH HHS R01 EY024618
6 · The paper itself

Abstract

The mechanisms underlying the increased susceptibility of the elderly to respiratory infections are not well understood. The crosstalk between the dendritic cells (DCs) and epithelial cells is essential in maintaining tolerance as well as in generating immunity in the respiratory mucosa. DCs from aged subjects display an enhanced basal level of activation, which can affect the function of epithelial cells. Our results suggest that this is indeed the scenario as exposure of primary bronchial epithelial cells (PBECs) to supernatants from unstimulated DCs of aged subjects resulted in activation of PBECs. The expression of CCL20, CCL26, CXCL10, mucin, and CD54 was significantly increased in the PBECs exposed to aged DC supernatants, but not to young DC supernatants. Furthermore, aged DC supernatants also enhanced the permeability of the PBEC barrier. We also found that DCs from aged subjects spontaneously secreted increased levels of pro-inflammatory mediators, interleukin-6, tumor necrosis factor (TNF)-α, and metalloproteinase A disintegrin family of metalloproteinase 10, which can affect the functions of PBECs. Finally, we demonstrated that TNF-α, present in the supernatant of DCs from aged subjects, was the primary pro-inflammatory mediator that affected PBEC functions. Thus, age-associated alterations in DC-epithelial interactions contribute to chronic airway inflammation in the elderly, increasing their susceptibility to respiratory diseases.

Indexed as

AdultAgedAged, 80 and overAgingBronchiCell CommunicationCells, CulturedChronic DiseaseDendritic CellsEpithelial CellsFemaleHumansInflammation MediatorsMaleMiddle AgedRespiratory MucosaInflammation Mediators

Identifiers

PMID24759206
PMCPMC4205198
OpenAlexW2031529000

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.