Evidence map›Paper›PMID 24759075›Full record

ArticleMolecules (Basel, Switzerland)2014

Antioxidant and antitumor activities of new synthesized aromatic C-nucleoside derivatives.

Mohamed M El Sadek, Nagwa S Abd El-Dayem, Seham Y Hassan, Mohamed A Mostafa, Galila A Yacout

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mohamed M El SadekChemistry Department, Faculty of Science, Alexandria University, Alexandria 21231, Egypt. mohamed.elsadik@alexu.edu.eg.
Nagwa S Abd El-DayemChemistry Department, Faculty of Science, Alexandria University, Alexandria 21231, Egypt. nagwa_abdeldayem@yahoo.com.
Seham Y HassanChemistry Department, Faculty of Science, Alexandria University, Alexandria 21231, Egypt. sehamyassen@yahoo.com.
Mohamed A MostafaChemistry Department, Faculty of Science, Alexandria University, Alexandria 21231, Egypt. dr_abdel_zaher@hotmail.com.
Galila A YacoutBiochemistry Department, Faculty of Science, Alexandria University, Alexandria 21231, Egypt. galila_69@yahoo.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The carbohydrazide 1 was used as the precursor for the synthesis of a number of new aromatic C-nucleosides containing 1,3,4-oxadiazole 7, [1,3,4]oxadiazolo[2,3-a]isoindole 10b and pyrazole units 18. On the other hand, the thiosemicarbazone 20 was used as the key intermediate for synthesis of 1,3,4-oxadiazole  and 1,2,4-triazole-3-thione derivatives 21 and 23. The antioxidant activities of the prepared compounds were evaluated. The carbohydrazide 1 in particular was found to have potent antioxidant and antitumor activity.

Indexed as

Antineoplastic AgentsAntioxidantsBiphenyl CompoundsCell Line, TumorCell SurvivalHumansHydrazinesMolecular StructureNucleosidesOxadiazolesPicratesStructure-Activity RelationshipThiosemicarbazonesTriazoles1,1-diphenyl-2-picrylhydrazylAntineoplastic AgentsAntioxidantsBiphenyl CompoundscarbohydrazideHydrazinesNucleosidesOxadiazolesPicratesThiosemicarbazonesTriazoles

Identifiers

PMID24759075
PMCPMC6271343

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.